GENETIC DELETION OF TRANSLOCATOR PROTEIN EXACERBATES POST-SEPSIS SYNDROME WITH ACTIVATION OF THE C1Q PATHWAY IN SEPTIC MOUSE MODEL

Significant numbers of patients who survive sepsis exhibit psychiatric and cognitive impairments, termed post-sepsis syndrome. Understanding the underlying pathophysiology is essential to develop effective therapies. Translocator protein 18 kDa (TSPO) is a multifaceted mitochondrial protein implicat...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 2023-01, Vol.59 (1), p.82-90
Hauptverfasser:	Kikutani, Kazuya, Hosokawa, Koji, Giga, Hiroshi, Ota, Kohei, Matsumata, Miho, Zhu, Meina, Takemoto, Hidenori, Ji, Bin, Ohshimo, Shinichiro, Shime, Nobuaki, Aizawa, Hidenori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety - genetics Cognitive Dysfunction - genetics Complement C1q Inflammation - etiology Mice Receptors, GABA - genetics Sepsis - complications Sepsis - genetics Sepsis - metabolism
Online-Zugang:	Volltext
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