Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization

The platelet–signaling receptor glycoprotein VI (GPVI) is a promising antithrombotic target. We have previously raised a series of high-affinity nanobodies (Nbs) against GPVI and identified Nb2, Nb21, and Nb35 as potent GPVI inhibitors. The Nb2 binding site has been mapped to the D1 domain, which is...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2023-02, Vol.21 (2), p.317-328
Hauptverfasser:	Damaskinaki, Foteini-Nafsika, Jooss, Natalie J., Martin, Eleyna M., Clark, Joanne C., Thomas, Mark R., Poulter, Natalie S., Emsley, Jonas, Kellam, Barrie, Watson, Steve P., Slater, Alexandre
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Blood Platelets - metabolism Collagen - metabolism Dimerization glycoprotein VI Humans Ligands nanobody platelet activation Platelet Membrane Glycoproteins - metabolism Protein Binding thrombosis
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