Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease

Chronic kidney disease (CKD) accelerates vascular calcification via phenotypic switching of vascular smooth muscle cells (VSMCs). We investigated the roles of circulating small extracellular vesicles (sEVs) between the kidneys and VSMCs and uncovered relevant sEV-propagated microRNAs (miRNAs) and th...

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Veröffentlicht in:	Circulation research 2023-02, Vol.132 (4), p.415-431
Hauptverfasser:	Koide, Takaaki, Mandai, Shintaro, Kitaoka, Reo, Matsuki, Hisazumi, Chiga, Motoko, Yamamoto, Kouhei, Yoshioka, Kotaro, Yagi, Yohsuke, Suzuki, Soichiro, Fujiki, Tamami, Ando, Fumiaki, Mori, Takayasu, Susa, Koichiro, Iimori, Soichiro, Naito, Shotaro, Sohara, Eisei, Rai, Tatemitsu, Yokota, Takanori, Uchida, Shinichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Extracellular Vesicles - metabolism Mice MicroRNAs - genetics MicroRNAs - metabolism Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - metabolism Phosphorus - metabolism Rats Renal Insufficiency, Chronic - metabolism Vascular Calcification - metabolism Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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