Asymmetric Biomimetic Transamination of Trifluoromethyl Ketones

In the presence of chiral pyridoxamine 4b as the catalyst and 2,2-diphenylglycine (3) as the amine source, asymmetric biomimetic transamination of trifluoromethyl ketones produces optically active α-trifluoromethyl amines 6 in 81–98% yields with 88–95% ee’s under mild conditions.

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Veröffentlicht in:	Journal of organic chemistry 2023-06, Vol.88 (12), p.7849-7857
Hauptverfasser:	Cai, Weiqi, Cai, Dongchen, Liang, Hanyu, Ren, Xinyi, Zhao, Baoguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amination Amines Biomimetics Catalysis Ketones
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description	In the presence of chiral pyridoxamine 4b as the catalyst and 2,2-diphenylglycine (3) as the amine source, asymmetric biomimetic transamination of trifluoromethyl ketones produces optically active α-trifluoromethyl amines 6 in 81–98% yields with 88–95% ee’s under mild conditions.
doi_str_mv	10.1021/acs.joc.2c02329
format	Article
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subjects	Amination Amines Biomimetics Catalysis Ketones
title	Asymmetric Biomimetic Transamination of Trifluoromethyl Ketones
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