Evaluation of carbonate apatite as a bone substitute in rat extraction sockets from the perspective of mesenchymal stem cells
Carbonate apatite (CO3Ap) is a major inorganic bone component and an effective bone substitute. To clarify the function of CO3Ap, we compared differences among CO3Ap, hydroxyapatite (HAp), and β-tricalcium phosphate (β-TCP) by focusing on mesenchymal stem cells (MSCs) that have a role in wound heali...
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| Veröffentlicht in: | Dental Materials Journal 2023/03/25, Vol.42(2), pp.282-290 |
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| creator | TAKAHASHI, Ryosuke ATSUTA, Ikiru NARIMATSU, Ikue YAMAZA, Takayoshi ZHANG, Xiaoxu EGASHIRA, Yuki KOYANO, Kiyoshi AYUKAWA, Yasunori |
| description | Carbonate apatite (CO3Ap) is a major inorganic bone component and an effective bone substitute. To clarify the function of CO3Ap, we compared differences among CO3Ap, hydroxyapatite (HAp), and β-tricalcium phosphate (β-TCP) by focusing on mesenchymal stem cells (MSCs) that have a role in wound healing. For in vivo experiments, maxillary molars were removed and the bone substitute was inserted. MSC accumulation around extraction sockets was significantly promoted in CO3Ap and β-TCP groups. For in vitro experiments, MSCs were cultured with bone substitutes. The differentiation potential and amount of calcium deposition were significantly lower in CO3Ap and HAp groups than in the β-TCP group. Increases in insulin-like growth factor-I and vascular endothelial growth factor were found only in the CO3Ap group. CO3Ap-filled extraction sockets accumulated MSCs, and MSCs cultured in the presence of CO3Ap produced large amounts of growth factors. These results suggest that CO3Ap promotes healing of tooth extraction sockets. |
| doi_str_mv | 10.4012/dmj.2022-040 |
| format | Article |
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To clarify the function of CO3Ap, we compared differences among CO3Ap, hydroxyapatite (HAp), and β-tricalcium phosphate (β-TCP) by focusing on mesenchymal stem cells (MSCs) that have a role in wound healing. For in vivo experiments, maxillary molars were removed and the bone substitute was inserted. MSC accumulation around extraction sockets was significantly promoted in CO3Ap and β-TCP groups. For in vitro experiments, MSCs were cultured with bone substitutes. The differentiation potential and amount of calcium deposition were significantly lower in CO3Ap and HAp groups than in the β-TCP group. Increases in insulin-like growth factor-I and vascular endothelial growth factor were found only in the CO3Ap group. CO3Ap-filled extraction sockets accumulated MSCs, and MSCs cultured in the presence of CO3Ap produced large amounts of growth factors. These results suggest that CO3Ap promotes healing of tooth extraction sockets.</description><identifier>ISSN: 0287-4547</identifier><identifier>EISSN: 1881-1361</identifier><identifier>DOI: 10.4012/dmj.2022-040</identifier><identifier>PMID: 36696988</identifier><language>eng</language><publisher>Japan: The Japanese Society for Dental Materials and Devices</publisher><subject>Accumulation ; Animals ; Apatite ; Bone biomaterials ; Bone healing ; Bone Substitutes ; Calcium phosphates ; Calcium Phosphates - pharmacology ; Carbonate apatite ; Durapatite - pharmacology ; Growth factors ; Hydroxyapatite ; Insulin ; Mesenchymal Stem Cells ; Molars ; Rats ; Stem cells ; Substitute bone ; Teeth ; Tricalcium phosphate ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A ; Wound healing</subject><ispartof>Dental Materials Journal, 2023/03/25, Vol.42(2), pp.282-290</ispartof><rights>2023 The Japanese Society for Dental Materials and Devices</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c627t-7f7e77c6d343191eac112cd9bd5bf9be5b406fbd6ee41aebec63bb9280c578723</citedby><cites>FETCH-LOGICAL-c627t-7f7e77c6d343191eac112cd9bd5bf9be5b406fbd6ee41aebec63bb9280c578723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36696988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TAKAHASHI, Ryosuke</creatorcontrib><creatorcontrib>ATSUTA, Ikiru</creatorcontrib><creatorcontrib>NARIMATSU, Ikue</creatorcontrib><creatorcontrib>YAMAZA, Takayoshi</creatorcontrib><creatorcontrib>ZHANG, Xiaoxu</creatorcontrib><creatorcontrib>EGASHIRA, Yuki</creatorcontrib><creatorcontrib>KOYANO, Kiyoshi</creatorcontrib><creatorcontrib>AYUKAWA, Yasunori</creatorcontrib><creatorcontrib>Department of Molecular Cell Biology and Oral Anatomy</creatorcontrib><creatorcontrib>Faculty of Dental Science</creatorcontrib><creatorcontrib>Kyushu University</creatorcontrib><creatorcontrib>Section of Implant and Rehabilitative Dentistry</creatorcontrib><creatorcontrib>Division of Oral Rehabilitation</creatorcontrib><creatorcontrib>Division of Advanced Dental Devices and Therapeutics</creatorcontrib><title>Evaluation of carbonate apatite as a bone substitute in rat extraction sockets from the perspective of mesenchymal stem cells</title><title>Dental Materials Journal</title><addtitle>Dent. Mater. J.</addtitle><description>Carbonate apatite (CO3Ap) is a major inorganic bone component and an effective bone substitute. To clarify the function of CO3Ap, we compared differences among CO3Ap, hydroxyapatite (HAp), and β-tricalcium phosphate (β-TCP) by focusing on mesenchymal stem cells (MSCs) that have a role in wound healing. For in vivo experiments, maxillary molars were removed and the bone substitute was inserted. MSC accumulation around extraction sockets was significantly promoted in CO3Ap and β-TCP groups. For in vitro experiments, MSCs were cultured with bone substitutes. The differentiation potential and amount of calcium deposition were significantly lower in CO3Ap and HAp groups than in the β-TCP group. Increases in insulin-like growth factor-I and vascular endothelial growth factor were found only in the CO3Ap group. CO3Ap-filled extraction sockets accumulated MSCs, and MSCs cultured in the presence of CO3Ap produced large amounts of growth factors. These results suggest that CO3Ap promotes healing of tooth extraction sockets.</description><subject>Accumulation</subject><subject>Animals</subject><subject>Apatite</subject><subject>Bone biomaterials</subject><subject>Bone healing</subject><subject>Bone Substitutes</subject><subject>Calcium phosphates</subject><subject>Calcium Phosphates - pharmacology</subject><subject>Carbonate apatite</subject><subject>Durapatite - pharmacology</subject><subject>Growth factors</subject><subject>Hydroxyapatite</subject><subject>Insulin</subject><subject>Mesenchymal Stem Cells</subject><subject>Molars</subject><subject>Rats</subject><subject>Stem cells</subject><subject>Substitute bone</subject><subject>Teeth</subject><subject>Tricalcium phosphate</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A</subject><subject>Wound healing</subject><issn>0287-4547</issn><issn>1881-1361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1v1DAQxS0EotvCjTOyxIUDKbbj-OMIVSlIlbjA2bKdCZslcRbbqdgD_zvOZrtIXDzWm5_fjPwQekXJNSeUvW_H3TUjjFWEkydoQ5WiFa0FfYo2hClZ8YbLC3SZ0o4QroVSz9FFLYQWWqkN-nP7YIfZ5n4KeOqwt9FNwWbAdl_EpSZscdEAp9mlIs1F7AOONmP4naP1x7dp8j8hJ9zFacR5C3gPMe2hNB9gMR4hQfDbw2gHnDKM2MMwpBfoWWeHBC9P9Qp9_3T77eZzdf_17svNh_vKCyZzJTsJUnrR1rymmoL1lDLfatc2rtMOGseJ6FwrADi14MCL2jnNFPGNVJLVV-jt6ruP068ZUjZjn5YNbIBpToZJobWuGV_QN_-hu2mOoWxnmGJN-TXZiEK9Wykfp5QidGYf-9HGg6HELLGYEotZYjElloK_PpnOboT2DD_mUIC7FSjd3tthCkMf4N_o9kBaCKtlbUqQpRpCpSkRlwvTReFF5MXp4-q0S9n-gPMoG3PvBzjuxZlhx-O037nptzYaCPVfts64lA</recordid><startdate>20230325</startdate><enddate>20230325</enddate><creator>TAKAHASHI, Ryosuke</creator><creator>ATSUTA, Ikiru</creator><creator>NARIMATSU, Ikue</creator><creator>YAMAZA, Takayoshi</creator><creator>ZHANG, Xiaoxu</creator><creator>EGASHIRA, Yuki</creator><creator>KOYANO, Kiyoshi</creator><creator>AYUKAWA, Yasunori</creator><general>The Japanese Society for Dental Materials and Devices</general><general>Japanese Society for Dental Materials and Devices</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20230325</creationdate><title>Evaluation of carbonate apatite as a bone substitute in rat extraction sockets from the perspective of mesenchymal stem cells</title><author>TAKAHASHI, Ryosuke ; 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Mater. J.</addtitle><date>2023-03-25</date><risdate>2023</risdate><volume>42</volume><issue>2</issue><spage>282</spage><epage>290</epage><pages>282-290</pages><artnum>2022-040</artnum><issn>0287-4547</issn><eissn>1881-1361</eissn><abstract>Carbonate apatite (CO3Ap) is a major inorganic bone component and an effective bone substitute. To clarify the function of CO3Ap, we compared differences among CO3Ap, hydroxyapatite (HAp), and β-tricalcium phosphate (β-TCP) by focusing on mesenchymal stem cells (MSCs) that have a role in wound healing. For in vivo experiments, maxillary molars were removed and the bone substitute was inserted. MSC accumulation around extraction sockets was significantly promoted in CO3Ap and β-TCP groups. For in vitro experiments, MSCs were cultured with bone substitutes. The differentiation potential and amount of calcium deposition were significantly lower in CO3Ap and HAp groups than in the β-TCP group. 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| subjects | Accumulation Animals Apatite Bone biomaterials Bone healing Bone Substitutes Calcium phosphates Calcium Phosphates - pharmacology Carbonate apatite Durapatite - pharmacology Growth factors Hydroxyapatite Insulin Mesenchymal Stem Cells Molars Rats Stem cells Substitute bone Teeth Tricalcium phosphate Vascular endothelial growth factor Vascular Endothelial Growth Factor A Wound healing |
| title | Evaluation of carbonate apatite as a bone substitute in rat extraction sockets from the perspective of mesenchymal stem cells |
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