Engineering biology for sustainable 1,4-butanediol synthesis

Over the past decade, numerous approaches have been taken to replace unsustainable chemical syntheses with green biosynthetic alternatives. In a landmark paper, Yim et al. utilised an in silico-to-in vivo workflow to enable the high-level bioproduction of the unnatural small molecule 1,4-butanediol...

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Veröffentlicht in:	Trends in biotechnology (Regular ed.) 2023-03, Vol.41 (3), p.286-288
Hauptverfasser:	Trotter, Connor L., Babu, Gautham S., Wallace, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Biosynthesis Butanediol Butylene Glycols - chemistry Carbon Chemical industry Chemical synthesis Chemistry Coliforms Dehydrogenases E coli Engineering Environmental impact Enzymes Escherichia coli - genetics Ethanol Fermentation Glucose Kinases Metabolic Engineering Metabolism Metabolites Polyethylene terephthalate Raw materials Synthetic biology Workflow
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Beschreibung
Zusammenfassung:	Over the past decade, numerous approaches have been taken to replace unsustainable chemical syntheses with green biosynthetic alternatives. In a landmark paper, Yim et al. utilised an in silico-to-in vivo workflow to enable the high-level bioproduction of the unnatural small molecule 1,4-butanediol in the bacterium Escherichia coli.
ISSN:	0167-7799 1879-3096
DOI:	10.1016/j.tibtech.2023.01.006