Role of antigen‐presenting cells in non‐ulcerated skin lesions caused by Leishmania (Leishmania) infantum chagasi
In Central America, infection by Leishmania (Leishmania) infantum chagasi causes visceral leishmaniasis and non‐ulcerated cutaneous leishmaniasis (NUCL). This work aimed to evaluate the participation of subpopulations of antigen‐presenting cells in skin lesions of patients affected by NUCL through d...
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| Veröffentlicht in: | Parasite immunology 2023-03, Vol.45 (3), p.e12971-n/a |
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| creator | Sandoval Pacheco, Carmen M. Araujo Flores, Gabriela V. Ferreira, Aurea F. da Matta, Vânia L. R. Castro Gomes, Claudia M. Sosa‐Ochoa, Wilfredo H. Zúniga, Concepción Silveira, Fernando T. Corbett, Carlos E. P. Laurenti, Márcia D. |
| description | In Central America, infection by Leishmania (Leishmania) infantum chagasi causes visceral leishmaniasis and non‐ulcerated cutaneous leishmaniasis (NUCL). This work aimed to evaluate the participation of subpopulations of antigen‐presenting cells in skin lesions of patients affected by NUCL through double‐staining immunohistochemistry using cellular and intracellular markers. Twenty‐three skin biopsies from patients affected by NUCL were used. Histological sections stained by HE were used for histopathological study. Immunohistochemical studies were performed using primary antibodies against Langerhans cells, dermal dendritic cells, T lymphocytes, and the cytokines IL‐12, IFN‐γ, TNF‐α, iNOS, and IL‐10. The histopathological lesions were characterized by an inflammatory infiltrate, predominantly lymphohistiocytic, of variable intensity, with a diffuse arrangement associated with epithelioid granulomas and discreet parasitism. Double‐staining immunohistochemistry showed higher participation of dendritic cells producing the proinflammatory cytokine IL‐12 in relation to the other evaluated cytokines. Activation of the cellular immune response was marked by a higher density of CD8 Tc1‐lymphocytes followed by CD4 Th1‐lymphocytes producing mainly IFN‐γ. The data obtained in the present study suggest that antigen‐presenting cells play an important role in the in situ immune response through the production of proinflammatory cytokines, directing the cellular immune response preferentially to the Th1 and Tc1 types in NUCL caused by L. (L.) infantum chagasi. |
| doi_str_mv | 10.1111/pim.12971 |
| format | Article |
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R. ; Castro Gomes, Claudia M. ; Sosa‐Ochoa, Wilfredo H. ; Zúniga, Concepción ; Silveira, Fernando T. ; Corbett, Carlos E. P. ; Laurenti, Márcia D.</creator><creatorcontrib>Sandoval Pacheco, Carmen M. ; Araujo Flores, Gabriela V. ; Ferreira, Aurea F. ; da Matta, Vânia L. R. ; Castro Gomes, Claudia M. ; Sosa‐Ochoa, Wilfredo H. ; Zúniga, Concepción ; Silveira, Fernando T. ; Corbett, Carlos E. P. ; Laurenti, Márcia D.</creatorcontrib><description>In Central America, infection by Leishmania (Leishmania) infantum chagasi causes visceral leishmaniasis and non‐ulcerated cutaneous leishmaniasis (NUCL). This work aimed to evaluate the participation of subpopulations of antigen‐presenting cells in skin lesions of patients affected by NUCL through double‐staining immunohistochemistry using cellular and intracellular markers. Twenty‐three skin biopsies from patients affected by NUCL were used. Histological sections stained by HE were used for histopathological study. Immunohistochemical studies were performed using primary antibodies against Langerhans cells, dermal dendritic cells, T lymphocytes, and the cytokines IL‐12, IFN‐γ, TNF‐α, iNOS, and IL‐10. The histopathological lesions were characterized by an inflammatory infiltrate, predominantly lymphohistiocytic, of variable intensity, with a diffuse arrangement associated with epithelioid granulomas and discreet parasitism. Double‐staining immunohistochemistry showed higher participation of dendritic cells producing the proinflammatory cytokine IL‐12 in relation to the other evaluated cytokines. Activation of the cellular immune response was marked by a higher density of CD8 Tc1‐lymphocytes followed by CD4 Th1‐lymphocytes producing mainly IFN‐γ. The data obtained in the present study suggest that antigen‐presenting cells play an important role in the in situ immune response through the production of proinflammatory cytokines, directing the cellular immune response preferentially to the Th1 and Tc1 types in NUCL caused by L. (L.) infantum chagasi.</description><identifier>ISSN: 0141-9838</identifier><identifier>EISSN: 1365-3024</identifier><identifier>DOI: 10.1111/pim.12971</identifier><identifier>PMID: 36695719</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Antigen-Presenting Cells ; Antigens ; Biopsy ; CD4 antigen ; CD8 antigen ; cellular ; cutaneous ; Cutaneous leishmaniasis ; Cytokines ; Dendritic cells ; Humans ; Immune response (cell-mediated) ; immunity ; Immunohistochemistry ; Inflammation ; Interleukin-12 ; Langerhans cells ; Leishmania ; Leishmania infantum ; Leishmania infantum chagasi ; leishmaniasis ; Leishmaniasis, Cutaneous ; Leishmaniasis, Visceral ; Lymphocytes ; Lymphocytes T ; Nitric-oxide synthase ; Parasitic diseases ; Parasitism ; Skin diseases ; Skin lesions ; Visceral leishmaniasis</subject><ispartof>Parasite immunology, 2023-03, Vol.45 (3), p.e12971-n/a</ispartof><rights>2023 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3131-1dd84da06fa3ff7d1035c2368e95588498df00378060c6f1e214eebe0c5401fc3</cites><orcidid>0000-0002-0412-6060 ; 0000-0001-6566-4869 ; 0000-0003-3509-6121 ; 0000-0003-1387-7488 ; 0000-0002-2622-792X ; 0000-0001-9909-9466 ; 0000-0001-8560-7298 ; 0000-0003-1587-3085 ; 0000-0002-1080-2440</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpim.12971$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpim.12971$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36695719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sandoval Pacheco, Carmen M.</creatorcontrib><creatorcontrib>Araujo Flores, Gabriela V.</creatorcontrib><creatorcontrib>Ferreira, Aurea F.</creatorcontrib><creatorcontrib>da Matta, Vânia L. R.</creatorcontrib><creatorcontrib>Castro Gomes, Claudia M.</creatorcontrib><creatorcontrib>Sosa‐Ochoa, Wilfredo H.</creatorcontrib><creatorcontrib>Zúniga, Concepción</creatorcontrib><creatorcontrib>Silveira, Fernando T.</creatorcontrib><creatorcontrib>Corbett, Carlos E. P.</creatorcontrib><creatorcontrib>Laurenti, Márcia D.</creatorcontrib><title>Role of antigen‐presenting cells in non‐ulcerated skin lesions caused by Leishmania (Leishmania) infantum chagasi</title><title>Parasite immunology</title><addtitle>Parasite Immunol</addtitle><description>In Central America, infection by Leishmania (Leishmania) infantum chagasi causes visceral leishmaniasis and non‐ulcerated cutaneous leishmaniasis (NUCL). This work aimed to evaluate the participation of subpopulations of antigen‐presenting cells in skin lesions of patients affected by NUCL through double‐staining immunohistochemistry using cellular and intracellular markers. Twenty‐three skin biopsies from patients affected by NUCL were used. Histological sections stained by HE were used for histopathological study. Immunohistochemical studies were performed using primary antibodies against Langerhans cells, dermal dendritic cells, T lymphocytes, and the cytokines IL‐12, IFN‐γ, TNF‐α, iNOS, and IL‐10. The histopathological lesions were characterized by an inflammatory infiltrate, predominantly lymphohistiocytic, of variable intensity, with a diffuse arrangement associated with epithelioid granulomas and discreet parasitism. Double‐staining immunohistochemistry showed higher participation of dendritic cells producing the proinflammatory cytokine IL‐12 in relation to the other evaluated cytokines. Activation of the cellular immune response was marked by a higher density of CD8 Tc1‐lymphocytes followed by CD4 Th1‐lymphocytes producing mainly IFN‐γ. The data obtained in the present study suggest that antigen‐presenting cells play an important role in the in situ immune response through the production of proinflammatory cytokines, directing the cellular immune response preferentially to the Th1 and Tc1 types in NUCL caused by L. (L.) infantum chagasi.</description><subject>Antigen-Presenting Cells</subject><subject>Antigens</subject><subject>Biopsy</subject><subject>CD4 antigen</subject><subject>CD8 antigen</subject><subject>cellular</subject><subject>cutaneous</subject><subject>Cutaneous leishmaniasis</subject><subject>Cytokines</subject><subject>Dendritic cells</subject><subject>Humans</subject><subject>Immune response (cell-mediated)</subject><subject>immunity</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Interleukin-12</subject><subject>Langerhans cells</subject><subject>Leishmania</subject><subject>Leishmania infantum</subject><subject>Leishmania infantum chagasi</subject><subject>leishmaniasis</subject><subject>Leishmaniasis, Cutaneous</subject><subject>Leishmaniasis, Visceral</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Nitric-oxide synthase</subject><subject>Parasitic diseases</subject><subject>Parasitism</subject><subject>Skin diseases</subject><subject>Skin lesions</subject><subject>Visceral leishmaniasis</subject><issn>0141-9838</issn><issn>1365-3024</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtOwzAQhi0EgvJYcAFkiU1ZpPXESewsUcWjUhEIwTpynXExJE6JG6HuOAJn5CS4lIeEhDe2x58-jecn5BDYAMIazm09gDgXsEF6wLM04ixONkmPQQJRLrncIbvePzIGPM74NtnhWZanAvIe6W6bCmljqHILO0P3_vo2b9FjuLkZ1VhVnlpHXbN66SqNrVpgSf1TKFbobeM81arzoTZd0gla_1ArZxXt_55PgsEEf1dT_aBmytt9smVU5fHga98j9-dnd6PLaHJ9MR6dTiLNgUMEZSmTUrHMKG6MKIHxVMc8k5inqZRJLkvDGBeSZUxnBjCGBHGKTKcJA6P5HumvvfO2ee7QL4ra-tWnlMOm80UswhxykCADevwHfWy61oXuAiUEFwkTSaBO1pRuG-9bNMW8tbVqlwWwYpVFEbIoPrMI7NGXsZvWWP6Q38MPwHANvNgKl_-bipvx1Vr5AVpWlTs</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Sandoval Pacheco, Carmen M.</creator><creator>Araujo Flores, Gabriela V.</creator><creator>Ferreira, Aurea F.</creator><creator>da Matta, Vânia L. 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P.</creator><creator>Laurenti, Márcia D.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0412-6060</orcidid><orcidid>https://orcid.org/0000-0001-6566-4869</orcidid><orcidid>https://orcid.org/0000-0003-3509-6121</orcidid><orcidid>https://orcid.org/0000-0003-1387-7488</orcidid><orcidid>https://orcid.org/0000-0002-2622-792X</orcidid><orcidid>https://orcid.org/0000-0001-9909-9466</orcidid><orcidid>https://orcid.org/0000-0001-8560-7298</orcidid><orcidid>https://orcid.org/0000-0003-1587-3085</orcidid><orcidid>https://orcid.org/0000-0002-1080-2440</orcidid></search><sort><creationdate>202303</creationdate><title>Role of antigen‐presenting cells in non‐ulcerated skin lesions caused by Leishmania (Leishmania) infantum chagasi</title><author>Sandoval Pacheco, Carmen M. ; Araujo Flores, Gabriela V. ; Ferreira, Aurea F. ; da Matta, Vânia L. R. ; Castro Gomes, Claudia M. ; Sosa‐Ochoa, Wilfredo H. ; Zúniga, Concepción ; Silveira, Fernando T. ; Corbett, Carlos E. 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P.</au><au>Laurenti, Márcia D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of antigen‐presenting cells in non‐ulcerated skin lesions caused by Leishmania (Leishmania) infantum chagasi</atitle><jtitle>Parasite immunology</jtitle><addtitle>Parasite Immunol</addtitle><date>2023-03</date><risdate>2023</risdate><volume>45</volume><issue>3</issue><spage>e12971</spage><epage>n/a</epage><pages>e12971-n/a</pages><issn>0141-9838</issn><eissn>1365-3024</eissn><abstract>In Central America, infection by Leishmania (Leishmania) infantum chagasi causes visceral leishmaniasis and non‐ulcerated cutaneous leishmaniasis (NUCL). This work aimed to evaluate the participation of subpopulations of antigen‐presenting cells in skin lesions of patients affected by NUCL through double‐staining immunohistochemistry using cellular and intracellular markers. Twenty‐three skin biopsies from patients affected by NUCL were used. Histological sections stained by HE were used for histopathological study. Immunohistochemical studies were performed using primary antibodies against Langerhans cells, dermal dendritic cells, T lymphocytes, and the cytokines IL‐12, IFN‐γ, TNF‐α, iNOS, and IL‐10. The histopathological lesions were characterized by an inflammatory infiltrate, predominantly lymphohistiocytic, of variable intensity, with a diffuse arrangement associated with epithelioid granulomas and discreet parasitism. Double‐staining immunohistochemistry showed higher participation of dendritic cells producing the proinflammatory cytokine IL‐12 in relation to the other evaluated cytokines. Activation of the cellular immune response was marked by a higher density of CD8 Tc1‐lymphocytes followed by CD4 Th1‐lymphocytes producing mainly IFN‐γ. The data obtained in the present study suggest that antigen‐presenting cells play an important role in the in situ immune response through the production of proinflammatory cytokines, directing the cellular immune response preferentially to the Th1 and Tc1 types in NUCL caused by L. (L.) infantum chagasi.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36695719</pmid><doi>10.1111/pim.12971</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-0412-6060</orcidid><orcidid>https://orcid.org/0000-0001-6566-4869</orcidid><orcidid>https://orcid.org/0000-0003-3509-6121</orcidid><orcidid>https://orcid.org/0000-0003-1387-7488</orcidid><orcidid>https://orcid.org/0000-0002-2622-792X</orcidid><orcidid>https://orcid.org/0000-0001-9909-9466</orcidid><orcidid>https://orcid.org/0000-0001-8560-7298</orcidid><orcidid>https://orcid.org/0000-0003-1587-3085</orcidid><orcidid>https://orcid.org/0000-0002-1080-2440</orcidid></addata></record> |
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| subjects | Antigen-Presenting Cells Antigens Biopsy CD4 antigen CD8 antigen cellular cutaneous Cutaneous leishmaniasis Cytokines Dendritic cells Humans Immune response (cell-mediated) immunity Immunohistochemistry Inflammation Interleukin-12 Langerhans cells Leishmania Leishmania infantum Leishmania infantum chagasi leishmaniasis Leishmaniasis, Cutaneous Leishmaniasis, Visceral Lymphocytes Lymphocytes T Nitric-oxide synthase Parasitic diseases Parasitism Skin diseases Skin lesions Visceral leishmaniasis |
| title | Role of antigen‐presenting cells in non‐ulcerated skin lesions caused by Leishmania (Leishmania) infantum chagasi |
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