Neural mechanism underlying depressive-like state associated with social status loss

Downward social mobility is a well-known mental risk factor for depression, but its neural mechanism remains elusive. Here, by forcing mice to lose against their subordinates in a non-violent social contest, we lower their social ranks stably and induce depressive-like behaviors. These rank-decline-...

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Veröffentlicht in:	Cell 2023-02, Vol.186 (3), p.560-576.e17
Hauptverfasser:	Fan, Zhengxiao, Chang, Jiarui, Liang, Yilan, Zhu, Hong, Zhang, Chaoyi, Zheng, Diyang, Wang, Junying, Xu, Ying, Li, Qi-Jing, Hu, Hailan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals burst Depression Habenula - physiology ketamine lateral habenula Mice Reward reward prediction error Social Behavior social competition social hierarchy Social Status
Online-Zugang:	Volltext
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