Interplay between the catecholaminergic enzymatic axis and neurodegeneration/neuroinflammation processes in the Alzheimer's disease continuum

Background and Purpose The locus coeruleus (LC) provides dopamine/noradrenaline (DA/NA) innervation throughout the brain and undergoes early degeneration in Alzheimer's disease (AD). We evaluated catecholaminergic enzyme levels in the cerebrospinal fluid (CSF) of a group of patients biologicall...

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Veröffentlicht in:	European journal of neurology 2023-04, Vol.30 (4), p.839-848
Hauptverfasser:	Motta, Caterina, Assogna, Martina, Bonomi, Chiara Giuseppina, Di Lorenzo, Francesco, Nuccetelli, Marzia, Mercuri, Nicola Biagio, Koch, Giacomo, Martorana, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - cerebrospinal fluid Apolipoprotein E Biomarkers Biomarkers - cerebrospinal fluid catecholaminergic enzymes Cerebrospinal fluid Cognitive ability CSF biomarkers Cytokines Degeneration Dihydroxyphenylalanine Dopamine Dopamine transporter Dopamine β-monooxygenase Genotypes Growth factors Humans Inflammation Innervation Interleukins Leukocytes (granulocytic) Locus coeruleus Mixed Function Oxygenases Neurodegeneration Neurodegenerative diseases neuroinflammation Neuroinflammatory Diseases Noradrenaline Norepinephrine Pathology Peptide Fragments - cerebrospinal fluid Subgroups Tau protein tau Proteins - cerebrospinal fluid Tyrosine
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