Melatonin inhibits atherosclerosis progression via galectin‐3 downregulation to enhance autophagy and inhibit inflammation

Autophagy deficiency in macrophages exacerbates inflammation in atherosclerosis (AS), and recently, galectin‐3 (Gal‐3) has been implicated as a critical promoter of inflammation in AS. Further, melatonin (Mel) exerts an autophagy‐promoting effect in many chronic inflammatory diseases. In this study,...

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Veröffentlicht in:	Journal of pineal research 2023-04, Vol.74 (3), p.e12855-n/a
Hauptverfasser:	Wang, Zitong, Gao, Ziyu, Zheng, Yinghong, Kou, Jiayuan, Song, Dan, Yu, Xue, Dong, Bowen, Chen, Tianzuo, Yang, Yan, Gao, Xi, Wang, Qianxue, Ye, Ting, Yang, Wei, Zhang, Xu, Li, Hong, Yang, Liming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - genetics Apolipoproteins E - metabolism Atherosclerosis - drug therapy Atherosclerosis - genetics Autophagy CD98 Down-Regulation Galectin 3 - genetics Galectin 3 - metabolism Galectin 3 - pharmacology inflammation Inflammation - metabolism macrophages Melatonin - pharmacology Mice NF-kappa B - metabolism NF‐κB Phosphatidylinositol 3-Kinases - metabolism PI3K Signal Transduction TFEB
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