Global, regional and national burden of alopecia areata and its associated diseases, 1990–2019: A systematic analysis of the Global Burden of Disease Study 2019
Background No study to date has concomitantly reported the global burden of alopecia areata (AA) and its associated diseases. Methods The crude and age‐standardized rates of prevalence (ASPR), incidence (ASIR) and years lived with disability (YLDs) of AA were extracted from the global burden of dise...
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| Veröffentlicht in: | European journal of clinical investigation 2023-06, Vol.53 (6), p.e13958-n/a |
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| creator | Jang, Hyeokjoo Park, Seoyeon Kim, Min Seo Yon, Dong Keon Lee, Seung Won Koyanagi, Ai Kostev, Karel Shin, Jae Il Smith, Lee |
| description | Background
No study to date has concomitantly reported the global burden of alopecia areata (AA) and its associated diseases.
Methods
The crude and age‐standardized rates of prevalence (ASPR), incidence (ASIR) and years lived with disability (YLDs) of AA were extracted from the global burden of disease, injuries and risk factors study (GBD) database between 1990 and 2019 for 204 countries and territories. We stratified the analysis by global region, nation, sex, age and sociodemographic index (SDI) to dissect the epidemiology of AA and its associated diseases.
Results
Alopecia areata was responsible for 0.024% of the total DALYs. Age‐standardized DALYs rate of AA was 7.51 [4.73–11.14] per 100,000. Overall ASPR, ASIR and age‐standardized YLDs rates were stable from 1990 to 2019 globally. All three rates were about two times higher in females compared to males and had a bimodal distribution with peaks at age 30–34 years and 60–64 years. AA burden was positively correlated with SDI (r = .375, p |
| doi_str_mv | 10.1111/eci.13958 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2769375277</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2769375277</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3538-4adebbc285d3ffd27dff46c6a864d24d3a676d2577f9f421218a10f4097ac3a73</originalsourceid><addsrcrecordid>eNp1kU9u1TAQhy0Eoo_CggsgS2yo1LT-k9hxd-XRlkqVWADraBLbkMovfngSoey4Q2_A0ThJ_ZrSRaV6Y3n0-ftpZgh5y9kRz-fYdf0Rl6aqn5EVl6oqhFTiOVkxxstCGC32yCvEa8ZYzaV4SfakUkZwoVbk70WILYRDmtyPPg4QKAyWDjAuj3ZK1g00egohbnMOUEgORrjD-hEpIMZcHp2ltkcH6PCQcmPYvz83gnFzQk8pzji6TXZ2-RuEGXvcKcefji7x9ONDzqdFQr-Ok53pzvCavPAQ0L25v_fJ9_Ozb-vPxdWXi8v16VXRyUrWRQnWtW0n6spK763Q1vtSdQpqVVpRWglKKysqrb3xZe6e18CZL5nR0EnQcp98WLzbFH9NDsdm02PnQoDBxQkboZWRuhJ6h75_hF7HKeXWMpVHXNZCSpWpg4XqUkRMzjfb1G8gzQ1nzW5xTR5oc7e4zL67N07txtkH8v-mMnC8AL_74OanTc3Z-nJR3gKa5aGB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2813482336</pqid></control><display><type>article</type><title>Global, regional and national burden of alopecia areata and its associated diseases, 1990–2019: A systematic analysis of the Global Burden of Disease Study 2019</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Jang, Hyeokjoo ; Park, Seoyeon ; Kim, Min Seo ; Yon, Dong Keon ; Lee, Seung Won ; Koyanagi, Ai ; Kostev, Karel ; Shin, Jae Il ; Smith, Lee</creator><creatorcontrib>Jang, Hyeokjoo ; Park, Seoyeon ; Kim, Min Seo ; Yon, Dong Keon ; Lee, Seung Won ; Koyanagi, Ai ; Kostev, Karel ; Shin, Jae Il ; Smith, Lee</creatorcontrib><description>Background
No study to date has concomitantly reported the global burden of alopecia areata (AA) and its associated diseases.
Methods
The crude and age‐standardized rates of prevalence (ASPR), incidence (ASIR) and years lived with disability (YLDs) of AA were extracted from the global burden of disease, injuries and risk factors study (GBD) database between 1990 and 2019 for 204 countries and territories. We stratified the analysis by global region, nation, sex, age and sociodemographic index (SDI) to dissect the epidemiology of AA and its associated diseases.
Results
Alopecia areata was responsible for 0.024% of the total DALYs. Age‐standardized DALYs rate of AA was 7.51 [4.73–11.14] per 100,000. Overall ASPR, ASIR and age‐standardized YLDs rates were stable from 1990 to 2019 globally. All three rates were about two times higher in females compared to males and had a bimodal distribution with peaks at age 30–34 years and 60–64 years. AA burden was positively correlated with SDI (r = .375, p < .001) and was most prevalent in high‐income countries, especially North America. Countries with a high AA incidence were more likely to have high incidences of autoimmune diseases and low incidences of ischaemic heart disease and ischaemic stroke.
Conclusions
The burden of AA was prominent in females, young adults, high sociodemographic countries and North Americans. The study corroborates sex‐ and region‐specific implications and public health measures for AA and its associated burdens. These epidemiological data on AA burden can guide future research efforts, prevention strategies and allocation of resources.
The burden of alopecia areata was prominent in females, high sociodemographic countries, North Americans and young adults, while the trend varies by regions. Alopecia areata is associated with multiple diseases, and the pattern was heterogeneous across GBD super regions, corroborating region‐specific implications and public health measures.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1111/eci.13958</identifier><identifier>PMID: 36692126</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Age ; Age composition ; Alopecia ; alopecia areata ; Alopecia Areata - epidemiology ; autoimmune disease ; Autoimmune diseases ; Baldness ; Brain Ischemia ; Cardiovascular diseases ; disability‐adjusted life years ; Disease prevention ; Epidemiology ; Female ; Females ; GBD 2019 ; Global Burden of Disease ; Global Health ; Health risks ; Heart diseases ; Humans ; Incidence ; Ischemia ; Male ; Prevalence ; Public health ; Quality-Adjusted Life Years ; Resource allocation ; Risk factors ; Sex ; Sociodemographics ; Stroke ; years of living with disability ; Young Adult ; Young adults</subject><ispartof>European journal of clinical investigation, 2023-06, Vol.53 (6), p.e13958-n/a</ispartof><rights>2023 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd</rights><rights>2023 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2023 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3538-4adebbc285d3ffd27dff46c6a864d24d3a676d2577f9f421218a10f4097ac3a73</citedby><cites>FETCH-LOGICAL-c3538-4adebbc285d3ffd27dff46c6a864d24d3a676d2577f9f421218a10f4097ac3a73</cites><orcidid>0000-0003-1628-9948 ; 0000-0001-5632-5208 ; 0000-0003-2326-1820 ; 0000-0001-9667-2060</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Feci.13958$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Feci.13958$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36692126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jang, Hyeokjoo</creatorcontrib><creatorcontrib>Park, Seoyeon</creatorcontrib><creatorcontrib>Kim, Min Seo</creatorcontrib><creatorcontrib>Yon, Dong Keon</creatorcontrib><creatorcontrib>Lee, Seung Won</creatorcontrib><creatorcontrib>Koyanagi, Ai</creatorcontrib><creatorcontrib>Kostev, Karel</creatorcontrib><creatorcontrib>Shin, Jae Il</creatorcontrib><creatorcontrib>Smith, Lee</creatorcontrib><title>Global, regional and national burden of alopecia areata and its associated diseases, 1990–2019: A systematic analysis of the Global Burden of Disease Study 2019</title><title>European journal of clinical investigation</title><addtitle>Eur J Clin Invest</addtitle><description>Background
No study to date has concomitantly reported the global burden of alopecia areata (AA) and its associated diseases.
Methods
The crude and age‐standardized rates of prevalence (ASPR), incidence (ASIR) and years lived with disability (YLDs) of AA were extracted from the global burden of disease, injuries and risk factors study (GBD) database between 1990 and 2019 for 204 countries and territories. We stratified the analysis by global region, nation, sex, age and sociodemographic index (SDI) to dissect the epidemiology of AA and its associated diseases.
Results
Alopecia areata was responsible for 0.024% of the total DALYs. Age‐standardized DALYs rate of AA was 7.51 [4.73–11.14] per 100,000. Overall ASPR, ASIR and age‐standardized YLDs rates were stable from 1990 to 2019 globally. All three rates were about two times higher in females compared to males and had a bimodal distribution with peaks at age 30–34 years and 60–64 years. AA burden was positively correlated with SDI (r = .375, p < .001) and was most prevalent in high‐income countries, especially North America. Countries with a high AA incidence were more likely to have high incidences of autoimmune diseases and low incidences of ischaemic heart disease and ischaemic stroke.
Conclusions
The burden of AA was prominent in females, young adults, high sociodemographic countries and North Americans. The study corroborates sex‐ and region‐specific implications and public health measures for AA and its associated burdens. These epidemiological data on AA burden can guide future research efforts, prevention strategies and allocation of resources.
The burden of alopecia areata was prominent in females, high sociodemographic countries, North Americans and young adults, while the trend varies by regions. Alopecia areata is associated with multiple diseases, and the pattern was heterogeneous across GBD super regions, corroborating region‐specific implications and public health measures.</description><subject>Adult</subject><subject>Age</subject><subject>Age composition</subject><subject>Alopecia</subject><subject>alopecia areata</subject><subject>Alopecia Areata - epidemiology</subject><subject>autoimmune disease</subject><subject>Autoimmune diseases</subject><subject>Baldness</subject><subject>Brain Ischemia</subject><subject>Cardiovascular diseases</subject><subject>disability‐adjusted life years</subject><subject>Disease prevention</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Females</subject><subject>GBD 2019</subject><subject>Global Burden of Disease</subject><subject>Global Health</subject><subject>Health risks</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Ischemia</subject><subject>Male</subject><subject>Prevalence</subject><subject>Public health</subject><subject>Quality-Adjusted Life Years</subject><subject>Resource allocation</subject><subject>Risk factors</subject><subject>Sex</subject><subject>Sociodemographics</subject><subject>Stroke</subject><subject>years of living with disability</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9u1TAQhy0Eoo_CggsgS2yo1LT-k9hxd-XRlkqVWADraBLbkMovfngSoey4Q2_A0ThJ_ZrSRaV6Y3n0-ftpZgh5y9kRz-fYdf0Rl6aqn5EVl6oqhFTiOVkxxstCGC32yCvEa8ZYzaV4SfakUkZwoVbk70WILYRDmtyPPg4QKAyWDjAuj3ZK1g00egohbnMOUEgORrjD-hEpIMZcHp2ltkcH6PCQcmPYvz83gnFzQk8pzji6TXZ2-RuEGXvcKcefji7x9ONDzqdFQr-Ok53pzvCavPAQ0L25v_fJ9_Ozb-vPxdWXi8v16VXRyUrWRQnWtW0n6spK763Q1vtSdQpqVVpRWglKKysqrb3xZe6e18CZL5nR0EnQcp98WLzbFH9NDsdm02PnQoDBxQkboZWRuhJ6h75_hF7HKeXWMpVHXNZCSpWpg4XqUkRMzjfb1G8gzQ1nzW5xTR5oc7e4zL67N07txtkH8v-mMnC8AL_74OanTc3Z-nJR3gKa5aGB</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Jang, Hyeokjoo</creator><creator>Park, Seoyeon</creator><creator>Kim, Min Seo</creator><creator>Yon, Dong Keon</creator><creator>Lee, Seung Won</creator><creator>Koyanagi, Ai</creator><creator>Kostev, Karel</creator><creator>Shin, Jae Il</creator><creator>Smith, Lee</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1628-9948</orcidid><orcidid>https://orcid.org/0000-0001-5632-5208</orcidid><orcidid>https://orcid.org/0000-0003-2326-1820</orcidid><orcidid>https://orcid.org/0000-0001-9667-2060</orcidid></search><sort><creationdate>202306</creationdate><title>Global, regional and national burden of alopecia areata and its associated diseases, 1990–2019: A systematic analysis of the Global Burden of Disease Study 2019</title><author>Jang, Hyeokjoo ; Park, Seoyeon ; Kim, Min Seo ; Yon, Dong Keon ; Lee, Seung Won ; Koyanagi, Ai ; Kostev, Karel ; Shin, Jae Il ; Smith, Lee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3538-4adebbc285d3ffd27dff46c6a864d24d3a676d2577f9f421218a10f4097ac3a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age composition</topic><topic>Alopecia</topic><topic>alopecia areata</topic><topic>Alopecia Areata - epidemiology</topic><topic>autoimmune disease</topic><topic>Autoimmune diseases</topic><topic>Baldness</topic><topic>Brain Ischemia</topic><topic>Cardiovascular diseases</topic><topic>disability‐adjusted life years</topic><topic>Disease prevention</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Females</topic><topic>GBD 2019</topic><topic>Global Burden of Disease</topic><topic>Global Health</topic><topic>Health risks</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Incidence</topic><topic>Ischemia</topic><topic>Male</topic><topic>Prevalence</topic><topic>Public health</topic><topic>Quality-Adjusted Life Years</topic><topic>Resource allocation</topic><topic>Risk factors</topic><topic>Sex</topic><topic>Sociodemographics</topic><topic>Stroke</topic><topic>years of living with disability</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jang, Hyeokjoo</creatorcontrib><creatorcontrib>Park, Seoyeon</creatorcontrib><creatorcontrib>Kim, Min Seo</creatorcontrib><creatorcontrib>Yon, Dong Keon</creatorcontrib><creatorcontrib>Lee, Seung Won</creatorcontrib><creatorcontrib>Koyanagi, Ai</creatorcontrib><creatorcontrib>Kostev, Karel</creatorcontrib><creatorcontrib>Shin, Jae Il</creatorcontrib><creatorcontrib>Smith, Lee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jang, Hyeokjoo</au><au>Park, Seoyeon</au><au>Kim, Min Seo</au><au>Yon, Dong Keon</au><au>Lee, Seung Won</au><au>Koyanagi, Ai</au><au>Kostev, Karel</au><au>Shin, Jae Il</au><au>Smith, Lee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Global, regional and national burden of alopecia areata and its associated diseases, 1990–2019: A systematic analysis of the Global Burden of Disease Study 2019</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>Eur J Clin Invest</addtitle><date>2023-06</date><risdate>2023</risdate><volume>53</volume><issue>6</issue><spage>e13958</spage><epage>n/a</epage><pages>e13958-n/a</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Background
No study to date has concomitantly reported the global burden of alopecia areata (AA) and its associated diseases.
Methods
The crude and age‐standardized rates of prevalence (ASPR), incidence (ASIR) and years lived with disability (YLDs) of AA were extracted from the global burden of disease, injuries and risk factors study (GBD) database between 1990 and 2019 for 204 countries and territories. We stratified the analysis by global region, nation, sex, age and sociodemographic index (SDI) to dissect the epidemiology of AA and its associated diseases.
Results
Alopecia areata was responsible for 0.024% of the total DALYs. Age‐standardized DALYs rate of AA was 7.51 [4.73–11.14] per 100,000. Overall ASPR, ASIR and age‐standardized YLDs rates were stable from 1990 to 2019 globally. All three rates were about two times higher in females compared to males and had a bimodal distribution with peaks at age 30–34 years and 60–64 years. AA burden was positively correlated with SDI (r = .375, p < .001) and was most prevalent in high‐income countries, especially North America. Countries with a high AA incidence were more likely to have high incidences of autoimmune diseases and low incidences of ischaemic heart disease and ischaemic stroke.
Conclusions
The burden of AA was prominent in females, young adults, high sociodemographic countries and North Americans. The study corroborates sex‐ and region‐specific implications and public health measures for AA and its associated burdens. These epidemiological data on AA burden can guide future research efforts, prevention strategies and allocation of resources.
The burden of alopecia areata was prominent in females, high sociodemographic countries, North Americans and young adults, while the trend varies by regions. Alopecia areata is associated with multiple diseases, and the pattern was heterogeneous across GBD super regions, corroborating region‐specific implications and public health measures.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>36692126</pmid><doi>10.1111/eci.13958</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1628-9948</orcidid><orcidid>https://orcid.org/0000-0001-5632-5208</orcidid><orcidid>https://orcid.org/0000-0003-2326-1820</orcidid><orcidid>https://orcid.org/0000-0001-9667-2060</orcidid></addata></record> |
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| subjects | Adult Age Age composition Alopecia alopecia areata Alopecia Areata - epidemiology autoimmune disease Autoimmune diseases Baldness Brain Ischemia Cardiovascular diseases disability‐adjusted life years Disease prevention Epidemiology Female Females GBD 2019 Global Burden of Disease Global Health Health risks Heart diseases Humans Incidence Ischemia Male Prevalence Public health Quality-Adjusted Life Years Resource allocation Risk factors Sex Sociodemographics Stroke years of living with disability Young Adult Young adults |
| title | Global, regional and national burden of alopecia areata and its associated diseases, 1990–2019: A systematic analysis of the Global Burden of Disease Study 2019 |
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