Total Syntheses of (+)‐Villocarine A, (−)‐Apogeissoschizine, and (+)‐Geissoschizine

Total syntheses of geissoschizine‐type monoterpenoid indole alkaloids (MTIAs) are reported. An intramolecular Pictet‐Spengler cyclization was developed for the selective construction of the 3R stereocenter. The first total synthesis of (+)‐villocarine A was then achieved. Furthermore, the first tota...

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Veröffentlicht in:	Chemistry : a European journal 2023-03, Vol.29 (18), p.e202300179-n/a
Hauptverfasser:	Sakamoto, Jukiya, Kitajima, Mariko, Ishikawa, Hayato
Format:	Artikel
Sprache:	eng
Schlagworte:	bioinspired transformation Chemistry Isomerization monoterpenoid indole alkaloid Pictet−Spengler reaction quinolizidine Stereoselectivity Synthesis total synthesis
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