High levels of Myc expression are required for the robust proliferation of hepatocytes, but not for the sustained weak proliferation

In contrast to the robust proliferation exhibited following acute liver injury, hepatocytes exhibit long-lasting proliferative activity in chronic liver injury. The mechanistic differences between these distinct modes of proliferation are unclear. Hepatocytes exhibited robust proliferation that peak...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2023-04, Vol.1869 (4), p.166644-166644, Article 166644
Hauptverfasser:	Goto, Masanori, Ooshio, Takako, Yamamoto, Masahiro, Tanaka, Hiroki, Fujii, Yumiko, Meng, Lingtong, Kamikokura, Yuki, Okada, Yoko, Nishikawa, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation - genetics Hepatectomy Hepatocytes Hepatocytes - metabolism Liver - metabolism Liver regeneration Liver Regeneration - genetics Mice Myc Proliferation Proline metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism
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