Safety and efficacy of intra-arterial bone marrow mononuclear cell transplantation in patients with acute ischaemic stroke in Spain (IBIS trial): a phase 2, randomised, open-label, standard-of-care controlled, multicentre trial

Pilot clinical trials have shown the safety of intra-arterial bone marrow mononuclear cells (BMMNCs) in stroke. However, the efficacy of different doses of intra-arterial BMMNCs in patients with acute stroke has not been tested in a randomised clinical trial. We aimed to show safety and efficacy of...

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Veröffentlicht in:	Lancet neurology 2023-02, Vol.22 (2), p.137-146
Hauptverfasser:	Moniche, Francisco, Cabezas-Rodriguez, Juan Antonio, Valverde, Roberto, Escudero-Martinez, Irene, Lebrato-Hernandez, Lucia, Pardo-Galiana, Blanca, Ainz, Leire, Medina-Rodriguez, Manuel, de la Torre, Javier, Escamilla-Gomez, Virginia, Ortega-Quintanilla, Joaquin, Zapata-Arriaza, Elena, de Albóniga-Chindurza, Asier, Mancha, Fernando, Gamero, Miguel-Angel, Perez, Soledad, Espinosa-Rosso, Raul, Forero-Diaz, Lucia, Moya, Miguel, Piñero, Pilar, Calderón-Cabrera, Cristina, Nogueras, Sonia, Jimenez, Rosario, Martin, Vanesa, Delgado, Fernando, Ochoa-Sepúlveda, Juan-José, Quijano, Blanca, Mata, Rosario, Santos-González, Monica, Carmona-Sanchez, Gloria, Herrera, Concha, Gonzalez, Alejandro, Montaner, Joan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse events Autografts Bone Marrow Bone marrow transplantation Brain Ischemia - drug therapy Cell Transplantation Clinical trials Female Hematoma Hospitals Humans Injection Ischemia Ischemic Stroke Leukocytes (mononuclear) Male Medical imaging Middle Aged Patients Safety Spain Standard of care Stem cells Stroke Stroke - drug therapy Treatment Outcome Vital signs
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