Nailfold capillaroscopy as diagnostic test in patients with psoriasis and psoriatic arthritis: A systematic review
Up to 30 % of patients with psoriasis (PsO) develop psoriatic arthritis (PsA), and diagnosis can be difficult. Nailfold capillaroscopy (NC) is an easily applicable, non-invasive procedure to assess skin microcirculation. This systematic review investigates NC as diagnostic tool for PsO and PsA, incl...
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Veröffentlicht in: | Microvascular research 2023-05, Vol.147, p.104476-104476, Article 104476 |
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description | Up to 30 % of patients with psoriasis (PsO) develop psoriatic arthritis (PsA), and diagnosis can be difficult. Nailfold capillaroscopy (NC) is an easily applicable, non-invasive procedure to assess skin microcirculation. This systematic review investigates NC as diagnostic tool for PsO and PsA, including correlations between NC outcome measures to clinical and laboratory outcome measures. This systematic review was built on the PICO and PRISMA guidelines. In total 22 relevant studies were found Searching in the Web of Science, PubMed and Embase, latest update June 13th, 2022. The following NC outcome measures are found to be significantly more prevalent in PsO patients than healthy controls: reduced density, reduced length and more abnormal morphology. Likewise, in PsA patients, reduced density, more abnormal morphology, more microhaemorrhages and fewer hairpin shapes are found to be significantly more prevalent. Results were non-conclusive in terms of disease activity and duration with NC findings. Random-effects meta-analysis showed a significant reduction of density in PsO patients compared to healthy controls (studies: 6, n = 249; SMD = -0.91; 95 % CI [−1.41, −0.40], p = 0.0058, heterogeneity I2=74 %, AUC = 0.740) and in PsA patients compared to healthy controls (studies: 5, n = 130; SMD = -1.22; 95 % CI [−2.38, −0.06], p = 0.0432, heterogeneity I2=89 %, AUC = 0.806). No NC outcome measures were overall conclusive in differentiating PsO from PsA. Considering the conflicting results and small sample sizes further large-scale research on the identification of capillaroscopic changes in PsO and PsA and correlations with standardised clinical and laboratory outcome measures are necessary.
•Nailfold capillaroscopy is a non-invasive procedure to assess skin microcirculation.•This is a systematic review consisting of 22 articles.•Psoriasis patients have reduced density and more abnormal morphology of capillaries.•Psoriasis patients and psoriatic arthritis patients display similar results.•Further research on capillaroscopic changes in PsO and PsA is necessary. |
doi_str_mv | 10.1016/j.mvr.2023.104476 |
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•Nailfold capillaroscopy is a non-invasive procedure to assess skin microcirculation.•This is a systematic review consisting of 22 articles.•Psoriasis patients have reduced density and more abnormal morphology of capillaries.•Psoriasis patients and psoriatic arthritis patients display similar results.•Further research on capillaroscopic changes in PsO and PsA is necessary.</description><identifier>ISSN: 0026-2862</identifier><identifier>EISSN: 1095-9319</identifier><identifier>DOI: 10.1016/j.mvr.2023.104476</identifier><identifier>PMID: 36657709</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Arthritis, Psoriatic - diagnosis ; Dermoscopy ; Diagnostic research ; Diagnostic Tests, Routine ; Health Status ; Humans ; Microscopic Angioscopy ; Nail imaging ; Nailfold capillaroscopy ; Psoriasis ; Psoriasis arthritis</subject><ispartof>Microvascular research, 2023-05, Vol.147, p.104476-104476, Article 104476</ispartof><rights>2023 The Authors</rights><rights>Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-971ff656443c93a7295a4b5d82eb0b062e1f541f5fe27cd33bf0bc8f17430cd33</citedby><cites>FETCH-LOGICAL-c396t-971ff656443c93a7295a4b5d82eb0b062e1f541f5fe27cd33bf0bc8f17430cd33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mvr.2023.104476$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36657709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lazar, L.T.</creatorcontrib><creatorcontrib>Guldberg-Møller, J.</creatorcontrib><creatorcontrib>Lazar, B.T.</creatorcontrib><creatorcontrib>Mogensen, M.</creatorcontrib><title>Nailfold capillaroscopy as diagnostic test in patients with psoriasis and psoriatic arthritis: A systematic review</title><title>Microvascular research</title><addtitle>Microvasc Res</addtitle><description>Up to 30 % of patients with psoriasis (PsO) develop psoriatic arthritis (PsA), and diagnosis can be difficult. Nailfold capillaroscopy (NC) is an easily applicable, non-invasive procedure to assess skin microcirculation. This systematic review investigates NC as diagnostic tool for PsO and PsA, including correlations between NC outcome measures to clinical and laboratory outcome measures. This systematic review was built on the PICO and PRISMA guidelines. In total 22 relevant studies were found Searching in the Web of Science, PubMed and Embase, latest update June 13th, 2022. The following NC outcome measures are found to be significantly more prevalent in PsO patients than healthy controls: reduced density, reduced length and more abnormal morphology. Likewise, in PsA patients, reduced density, more abnormal morphology, more microhaemorrhages and fewer hairpin shapes are found to be significantly more prevalent. Results were non-conclusive in terms of disease activity and duration with NC findings. Random-effects meta-analysis showed a significant reduction of density in PsO patients compared to healthy controls (studies: 6, n = 249; SMD = -0.91; 95 % CI [−1.41, −0.40], p = 0.0058, heterogeneity I2=74 %, AUC = 0.740) and in PsA patients compared to healthy controls (studies: 5, n = 130; SMD = -1.22; 95 % CI [−2.38, −0.06], p = 0.0432, heterogeneity I2=89 %, AUC = 0.806). No NC outcome measures were overall conclusive in differentiating PsO from PsA. Considering the conflicting results and small sample sizes further large-scale research on the identification of capillaroscopic changes in PsO and PsA and correlations with standardised clinical and laboratory outcome measures are necessary.
•Nailfold capillaroscopy is a non-invasive procedure to assess skin microcirculation.•This is a systematic review consisting of 22 articles.•Psoriasis patients have reduced density and more abnormal morphology of capillaries.•Psoriasis patients and psoriatic arthritis patients display similar results.•Further research on capillaroscopic changes in PsO and PsA is necessary.</description><subject>Arthritis, Psoriatic - diagnosis</subject><subject>Dermoscopy</subject><subject>Diagnostic research</subject><subject>Diagnostic Tests, Routine</subject><subject>Health Status</subject><subject>Humans</subject><subject>Microscopic Angioscopy</subject><subject>Nail imaging</subject><subject>Nailfold capillaroscopy</subject><subject>Psoriasis</subject><subject>Psoriasis arthritis</subject><issn>0026-2862</issn><issn>1095-9319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDlPAzEQhS0EgnD8ABrkkmaDj11vDBWKuCQEDdSW12uDo73wOIny7_GSQEkxGr3Rmye9D6FzSqaUUHG1mLarMGWE8aTzvBR7aEKJLDLJqdxHE0KYyNhMsCN0DLAghNJCskN0xIUoypLICQov2jeub2ps9OCbRoceTD9ssAZce_3R9RC9wdFCxL7Dg47edhHw2sdPPEAfvAYPWHf1To1uHeJn8NHDNb7FsIFo2597sCtv16fowOkG7Nlun6D3-7u3-WP2_PrwNL99zgyXImaypM6JQuQ5N5LrkslC51VRz5itSEUEs9QVeRpnWWlqzitHKjNztMw5GfUJutzmDqH_WqYCqvVgbOrY2X4JipVixpignCYr3VpNqg_BOjUE3-qwUZSoEbVaqIRajajVFnX6udjFL6vW1n8fv2yT4WZrsKlkKh4UmATP2NoHa6Kqe_9P_DetJ5Ew</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Lazar, L.T.</creator><creator>Guldberg-Møller, J.</creator><creator>Lazar, B.T.</creator><creator>Mogensen, M.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202305</creationdate><title>Nailfold capillaroscopy as diagnostic test in patients with psoriasis and psoriatic arthritis: A systematic review</title><author>Lazar, L.T. ; Guldberg-Møller, J. ; Lazar, B.T. ; Mogensen, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-971ff656443c93a7295a4b5d82eb0b062e1f541f5fe27cd33bf0bc8f17430cd33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Arthritis, Psoriatic - diagnosis</topic><topic>Dermoscopy</topic><topic>Diagnostic research</topic><topic>Diagnostic Tests, Routine</topic><topic>Health Status</topic><topic>Humans</topic><topic>Microscopic Angioscopy</topic><topic>Nail imaging</topic><topic>Nailfold capillaroscopy</topic><topic>Psoriasis</topic><topic>Psoriasis arthritis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lazar, L.T.</creatorcontrib><creatorcontrib>Guldberg-Møller, J.</creatorcontrib><creatorcontrib>Lazar, B.T.</creatorcontrib><creatorcontrib>Mogensen, M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microvascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lazar, L.T.</au><au>Guldberg-Møller, J.</au><au>Lazar, B.T.</au><au>Mogensen, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nailfold capillaroscopy as diagnostic test in patients with psoriasis and psoriatic arthritis: A systematic review</atitle><jtitle>Microvascular research</jtitle><addtitle>Microvasc Res</addtitle><date>2023-05</date><risdate>2023</risdate><volume>147</volume><spage>104476</spage><epage>104476</epage><pages>104476-104476</pages><artnum>104476</artnum><issn>0026-2862</issn><eissn>1095-9319</eissn><abstract>Up to 30 % of patients with psoriasis (PsO) develop psoriatic arthritis (PsA), and diagnosis can be difficult. Nailfold capillaroscopy (NC) is an easily applicable, non-invasive procedure to assess skin microcirculation. This systematic review investigates NC as diagnostic tool for PsO and PsA, including correlations between NC outcome measures to clinical and laboratory outcome measures. This systematic review was built on the PICO and PRISMA guidelines. In total 22 relevant studies were found Searching in the Web of Science, PubMed and Embase, latest update June 13th, 2022. The following NC outcome measures are found to be significantly more prevalent in PsO patients than healthy controls: reduced density, reduced length and more abnormal morphology. Likewise, in PsA patients, reduced density, more abnormal morphology, more microhaemorrhages and fewer hairpin shapes are found to be significantly more prevalent. Results were non-conclusive in terms of disease activity and duration with NC findings. Random-effects meta-analysis showed a significant reduction of density in PsO patients compared to healthy controls (studies: 6, n = 249; SMD = -0.91; 95 % CI [−1.41, −0.40], p = 0.0058, heterogeneity I2=74 %, AUC = 0.740) and in PsA patients compared to healthy controls (studies: 5, n = 130; SMD = -1.22; 95 % CI [−2.38, −0.06], p = 0.0432, heterogeneity I2=89 %, AUC = 0.806). No NC outcome measures were overall conclusive in differentiating PsO from PsA. Considering the conflicting results and small sample sizes further large-scale research on the identification of capillaroscopic changes in PsO and PsA and correlations with standardised clinical and laboratory outcome measures are necessary.
•Nailfold capillaroscopy is a non-invasive procedure to assess skin microcirculation.•This is a systematic review consisting of 22 articles.•Psoriasis patients have reduced density and more abnormal morphology of capillaries.•Psoriasis patients and psoriatic arthritis patients display similar results.•Further research on capillaroscopic changes in PsO and PsA is necessary.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>36657709</pmid><doi>10.1016/j.mvr.2023.104476</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Arthritis, Psoriatic - diagnosis Dermoscopy Diagnostic research Diagnostic Tests, Routine Health Status Humans Microscopic Angioscopy Nail imaging Nailfold capillaroscopy Psoriasis Psoriasis arthritis |
title | Nailfold capillaroscopy as diagnostic test in patients with psoriasis and psoriatic arthritis: A systematic review |
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