Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1

Capsaicin receptor, also known as transient receptor potential vanilloid 1 (TRPV1), is involved in pain physiology and neurogenic inflammation. Herein, we discovered the presence of TRPV1 in hepatic stellate cells (HSCs) and aimed to delineate its function in this cell type and liver fibrosis. TRPV1...

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Veröffentlicht in:	Journal of hepatology 2023-04, Vol.78 (4), p.805-819
Hauptverfasser:	Tao, Le, Yang, Guangyue, Sun, Tiantian, Jie Tao, Zhu, Chan, Yu, Huimin, Cheng, Yalan, Yang, Zongguo, Xu, Mingyi, Jiang, Yuefeng, Zhang, Wei, Wang, Zhiyi, Ma, Wenting, Wu, Liu, Xue, Dongying, Wang, Dongxue, Yang, Wentao, Zhao, Yongjuan, Horsefield, Shane, Kobe, Bostjan, Zhang, Zhe, Tang, Zongxiang, Li, Qigen, Zhai, Qiwei, Dooley, Steven, Seki, Ekihiro, Liu, Ping, Xu, Jianrong, Chen, Hongzhuan, Liu, Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Armadillo Domain Proteins - genetics Armadillo Domain Proteins - metabolism Cytoskeletal Proteins - metabolism Cytoskeletal Proteins - pharmacology Gene Expression Regulation Hepatic Stellate Cells - metabolism HSC Humans Liver - pathology Liver Cirrhosis - pathology liver fibrosis Mice SARM1 TRPV Cation Channels - genetics TRPV Cation Channels - metabolism TRPV Cation Channels - pharmacology TRPV1
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