Synthesis and Functional Characterization of Novel RU1968-Derived CatSper Inhibitors with Reduced Stereochemical Complexity

The sperm-specific Ca2+ channel CatSper (cation channel of sperm) controls the intracellular Ca2+ concentration and, thereby, the swimming behavior of sperm from many species. The steroidal ethylenediamine RU1968 (1) represents a well-characterized, potent, and fairly selective cross-species inhibit...

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Veröffentlicht in:	ACS pharmacology & translational science 2023-01, Vol.6 (1), p.115-127
Hauptverfasser:	Schierling, Tobias, Tosi, Beatrice, Eisenhardt, Clara, Reining, Sophie, Daniliuc, Constantin G., Brenker, Christoph, Strünker, Timo, Wünsch, Bernhard
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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