Causes of Death in Elderly Patients With Non-Valvular Atrial Fibrillation ― Results From the ANAFIE Registry
Background: Previous studies on mortality in atrial fibrillation (AF) included a limited number of elderly patients receiving direct oral anticoagulants (DOACs). This subanalysis of the ANAFIE Registry evaluated 2-year mortality according to causes of death of elderly non-valvular AF (NVAF) patients...
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| Veröffentlicht in: | Circulation Journal 2023/06/23, Vol.87(7), pp.957-963 |
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| creator | Yamashita, Takeshi Akao, Masaharu Atarashi, Hirotsugu Ikeda, Takanori Koretsune, Yukihiro Okumura, Ken Shimizu, Wataru Suzuki, Shinya Tsutsui, Hiroyuki Toyoda, Kazunori Hirayama, Atsushi Yasaka, Masahiro Yamaguchi, Takenori Teramukai, Satoshi Kimura, Tetsuya Morishima, Yoshiyuki Takita, Atsushi Inoue, Hiroshi |
| description | Background: Previous studies on mortality in atrial fibrillation (AF) included a limited number of elderly patients receiving direct oral anticoagulants (DOACs). This subanalysis of the ANAFIE Registry evaluated 2-year mortality according to causes of death of elderly non-valvular AF (NVAF) patients in the DOAC era.Methods and Results: The ANAFIE Registry was a multicenter prospective observational study. Mean patient age was 81.5 years and 57.3% of patients were male. Of the 32,275 patients completing the study, 2,242 died. The most frequent causes of death were cardiovascular (CV) death (32.4%), followed by infection (17.1%) and malignancy (16.1%). Incidence rates of CV-, malignancy-, and infection-related death were 1.20, 0.60, and 0.63 per 100 person-years, respectively. Patients aged ≥85 years showed increased proportions of non-CV and non-malignancy deaths and a decreased proportion of malignancy deaths compared with patients aged |
| doi_str_mv | 10.1253/circj.CJ-22-0614 |
| format | Article |
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This subanalysis of the ANAFIE Registry evaluated 2-year mortality according to causes of death of elderly non-valvular AF (NVAF) patients in the DOAC era.Methods and Results: The ANAFIE Registry was a multicenter prospective observational study. Mean patient age was 81.5 years and 57.3% of patients were male. Of the 32,275 patients completing the study, 2,242 died. The most frequent causes of death were cardiovascular (CV) death (32.4%), followed by infection (17.1%) and malignancy (16.1%). Incidence rates of CV-, malignancy-, and infection-related death were 1.20, 0.60, and 0.63 per 100 person-years, respectively. Patients aged ≥85 years showed increased proportions of non-CV and non-malignancy deaths and a decreased proportion of malignancy deaths compared with patients aged <85 years. The incidence of death due to congestive heart failure/cardiogenic shock, infection, and renal disease was higher in patients aged ≥85 than those aged <85 years. Compared with warfarin, DOACs were associated with a significantly lower risk of death by intracranial hemorrhage, ischemic stroke, and renal disease.Conclusions: This subanalysis described the mortality according to causes of death of Japanese elderly NVAF patients in the DOAC era. Our results imply that a more holistic approach to comorbid conditions and stroke prevention are required in these patients.</description><identifier>ISSN: 1346-9843</identifier><identifier>ISSN: 1347-4820</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-22-0614</identifier><identifier>PMID: 36653127</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Administration, Oral ; Aged ; Anticoagulants - adverse effects ; Atrial Fibrillation - epidemiology ; Cause of Death ; Elderly ; Female ; Humans ; Japan ; Male ; Non-valvular atrial fibrillation ; Prospective Studies ; Real-world study ; Registries ; Risk Factors ; Stroke - etiology ; Treatment Outcome</subject><ispartof>Circulation Journal, 2023/06/23, Vol.87(7), pp.957-963</ispartof><rights>2023, THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-f33292329ae216fd7f9087447d82f11fb1916f92be1933506678e2cbcaee76693</citedby><cites>FETCH-LOGICAL-c494t-f33292329ae216fd7f9087447d82f11fb1916f92be1933506678e2cbcaee76693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36653127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamashita, Takeshi</creatorcontrib><creatorcontrib>Akao, Masaharu</creatorcontrib><creatorcontrib>Atarashi, Hirotsugu</creatorcontrib><creatorcontrib>Ikeda, Takanori</creatorcontrib><creatorcontrib>Koretsune, Yukihiro</creatorcontrib><creatorcontrib>Okumura, Ken</creatorcontrib><creatorcontrib>Shimizu, Wataru</creatorcontrib><creatorcontrib>Suzuki, Shinya</creatorcontrib><creatorcontrib>Tsutsui, Hiroyuki</creatorcontrib><creatorcontrib>Toyoda, Kazunori</creatorcontrib><creatorcontrib>Hirayama, Atsushi</creatorcontrib><creatorcontrib>Yasaka, Masahiro</creatorcontrib><creatorcontrib>Yamaguchi, Takenori</creatorcontrib><creatorcontrib>Teramukai, Satoshi</creatorcontrib><creatorcontrib>Kimura, Tetsuya</creatorcontrib><creatorcontrib>Morishima, Yoshiyuki</creatorcontrib><creatorcontrib>Takita, Atsushi</creatorcontrib><creatorcontrib>Inoue, Hiroshi</creatorcontrib><title>Causes of Death in Elderly Patients With Non-Valvular Atrial Fibrillation ― Results From the ANAFIE Registry</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background: Previous studies on mortality in atrial fibrillation (AF) included a limited number of elderly patients receiving direct oral anticoagulants (DOACs). This subanalysis of the ANAFIE Registry evaluated 2-year mortality according to causes of death of elderly non-valvular AF (NVAF) patients in the DOAC era.Methods and Results: The ANAFIE Registry was a multicenter prospective observational study. Mean patient age was 81.5 years and 57.3% of patients were male. Of the 32,275 patients completing the study, 2,242 died. The most frequent causes of death were cardiovascular (CV) death (32.4%), followed by infection (17.1%) and malignancy (16.1%). Incidence rates of CV-, malignancy-, and infection-related death were 1.20, 0.60, and 0.63 per 100 person-years, respectively. Patients aged ≥85 years showed increased proportions of non-CV and non-malignancy deaths and a decreased proportion of malignancy deaths compared with patients aged <85 years. The incidence of death due to congestive heart failure/cardiogenic shock, infection, and renal disease was higher in patients aged ≥85 than those aged <85 years. Compared with warfarin, DOACs were associated with a significantly lower risk of death by intracranial hemorrhage, ischemic stroke, and renal disease.Conclusions: This subanalysis described the mortality according to causes of death of Japanese elderly NVAF patients in the DOAC era. Our results imply that a more holistic approach to comorbid conditions and stroke prevention are required in these patients.</description><subject>Administration, Oral</subject><subject>Aged</subject><subject>Anticoagulants - adverse effects</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Cause of Death</subject><subject>Elderly</subject><subject>Female</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>Non-valvular atrial fibrillation</subject><subject>Prospective Studies</subject><subject>Real-world study</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Stroke - etiology</subject><subject>Treatment Outcome</subject><issn>1346-9843</issn><issn>1347-4820</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1O3DAUhS3UCiiwZ1V52U2ofxI7Xo7ChB8hWlWlXVpO5obxyJMMtoM0u3kJXrB9kXqYKSyur3X8nSPrIHROyQVlBf_aWt8uLqrbjLGMCJofoGPKc5nlJSMfXu8iU2XOj9CnEBaEMEUKdYiOuBAFp0weo1VlxgABDx2-BBPn2PZ46mbg3Rp_N9FCHwP-bdPD_dBnv4x7Hp3xeBK9NQ7XtvHWucQN_d_N5s_mBf-AMLrkqf2wxHEOeHI_qW-mSX-0Ifr1KfrYGRfgbL9P0EM9_VldZ3ffrm6qyV3W5iqPWcc5UyyNAUZFN5OdIqXMczkrWUdp11CVZMUaoIrzggghS2Bt0xoAKYTiJ-jLLnflh6cRQtRLG1pIn-1hGINmUkgqykLQhJId2vohBA-dXnm7NH6tKdHbnvVrz7q61Yzpbc_J8nmfPjZLmL0Z_hebgHoHLEI0j_AGGB9t62CfWEott8d78jswN15Dz_8BeraUTQ</recordid><startdate>20230623</startdate><enddate>20230623</enddate><creator>Yamashita, Takeshi</creator><creator>Akao, Masaharu</creator><creator>Atarashi, Hirotsugu</creator><creator>Ikeda, Takanori</creator><creator>Koretsune, Yukihiro</creator><creator>Okumura, Ken</creator><creator>Shimizu, Wataru</creator><creator>Suzuki, Shinya</creator><creator>Tsutsui, Hiroyuki</creator><creator>Toyoda, Kazunori</creator><creator>Hirayama, Atsushi</creator><creator>Yasaka, Masahiro</creator><creator>Yamaguchi, Takenori</creator><creator>Teramukai, Satoshi</creator><creator>Kimura, Tetsuya</creator><creator>Morishima, Yoshiyuki</creator><creator>Takita, Atsushi</creator><creator>Inoue, Hiroshi</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230623</creationdate><title>Causes of Death in Elderly Patients With Non-Valvular Atrial Fibrillation ― Results From the ANAFIE Registry</title><author>Yamashita, Takeshi ; 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This subanalysis of the ANAFIE Registry evaluated 2-year mortality according to causes of death of elderly non-valvular AF (NVAF) patients in the DOAC era.Methods and Results: The ANAFIE Registry was a multicenter prospective observational study. Mean patient age was 81.5 years and 57.3% of patients were male. Of the 32,275 patients completing the study, 2,242 died. The most frequent causes of death were cardiovascular (CV) death (32.4%), followed by infection (17.1%) and malignancy (16.1%). Incidence rates of CV-, malignancy-, and infection-related death were 1.20, 0.60, and 0.63 per 100 person-years, respectively. Patients aged ≥85 years showed increased proportions of non-CV and non-malignancy deaths and a decreased proportion of malignancy deaths compared with patients aged <85 years. The incidence of death due to congestive heart failure/cardiogenic shock, infection, and renal disease was higher in patients aged ≥85 than those aged <85 years. Compared with warfarin, DOACs were associated with a significantly lower risk of death by intracranial hemorrhage, ischemic stroke, and renal disease.Conclusions: This subanalysis described the mortality according to causes of death of Japanese elderly NVAF patients in the DOAC era. Our results imply that a more holistic approach to comorbid conditions and stroke prevention are required in these patients.</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>36653127</pmid><doi>10.1253/circj.CJ-22-0614</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Oral Aged Anticoagulants - adverse effects Atrial Fibrillation - epidemiology Cause of Death Elderly Female Humans Japan Male Non-valvular atrial fibrillation Prospective Studies Real-world study Registries Risk Factors Stroke - etiology Treatment Outcome |
| title | Causes of Death in Elderly Patients With Non-Valvular Atrial Fibrillation ― Results From the ANAFIE Registry |
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