A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury
Apoptosis repressor with caspase recruitment domain (ARC) acts as a potent and multifunctional inhibitor of apoptosis, which is mainly expressed in postmitotic cells, including cardiomyocytes. ARC is special for its N-terminal caspase recruitment domain and caspase recruitment domain. Due to the pow...
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| Veröffentlicht in: | Apoptosis (London) 2023-04, Vol.28 (3-4), p.313-325 |
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| container_title | Apoptosis (London) |
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| creator | Liu, Kun Lan, Dongfeng Li, Chunyang Liu, Songpo Dai, Xiaofang Song, Tao Wang, Xianyao Kong, Qinghong He, Zhixu Tan, Jun Zhang, Jidong |
| description | Apoptosis repressor with caspase recruitment domain (ARC) acts as a potent and multifunctional inhibitor of apoptosis, which is mainly expressed in postmitotic cells, including cardiomyocytes. ARC is special for its N-terminal caspase recruitment domain and caspase recruitment domain. Due to the powerful inhibition of apoptosis, ARC is mainly reported to act as a cardioprotective factor during ischaemia‒reperfusion (I/R) injury, preventing cardiomyocytes from being devastated by various catastrophes, including oxidative stress, calcium overload, and mitochondrial dysfunction in the circulatory system. However, recent studies have found that ARC also plays a potential regulatory role in tumorigenesis especially in colorectal cancer and renal cell carcinomas, through multiple apoptosis-associated pathways, which remains to be explored in further studies. Therefore, ARC regulates the body and maintains the balance of physiological activities with its interesting duplex. This review summarizes the current research progress of ARC in the field of tumorigenesis and ischaemia/reperfusion injury, to provide overall research status and new possibilities for researchers. |
| doi_str_mv | 10.1007/s10495-022-01802-4 |
| format | Article |
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ARC is special for its N-terminal caspase recruitment domain and caspase recruitment domain. Due to the powerful inhibition of apoptosis, ARC is mainly reported to act as a cardioprotective factor during ischaemia‒reperfusion (I/R) injury, preventing cardiomyocytes from being devastated by various catastrophes, including oxidative stress, calcium overload, and mitochondrial dysfunction in the circulatory system. However, recent studies have found that ARC also plays a potential regulatory role in tumorigenesis especially in colorectal cancer and renal cell carcinomas, through multiple apoptosis-associated pathways, which remains to be explored in further studies. Therefore, ARC regulates the body and maintains the balance of physiological activities with its interesting duplex. This review summarizes the current research progress of ARC in the field of tumorigenesis and ischaemia/reperfusion injury, to provide overall research status and new possibilities for researchers.</description><identifier>ISSN: 1360-8185</identifier><identifier>EISSN: 1573-675X</identifier><identifier>DOI: 10.1007/s10495-022-01802-4</identifier><identifier>PMID: 36652128</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Apoptosis ; Apoptosis - genetics ; Apoptosis Regulatory Proteins - metabolism ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Calcium (mitochondrial) ; Cancer ; Cancer Research ; Carcinogenesis - genetics ; Cardiomyocytes ; Caspase ; Caspase Activation and Recruitment Domain ; Cell Biology ; Cell Transformation, Neoplastic ; Circulatory system ; Colorectal carcinoma ; Disasters ; Domains ; Humans ; Injury prevention ; Ischemia ; Kidney cancer ; Mitochondria ; Oncology ; Oxidative stress ; Recruitment ; Renal cell carcinoma ; Reperfusion ; Reperfusion Injury - genetics ; Review ; Tumorigenesis ; Virology</subject><ispartof>Apoptosis (London), 2023-04, Vol.28 (3-4), p.313-325</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. 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The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-2b39fe658d47346cf47e277bfe7db06df8fa5e1b4e92a6fc7f7f82b5e1e9fd643</citedby><cites>FETCH-LOGICAL-c375t-2b39fe658d47346cf47e277bfe7db06df8fa5e1b4e92a6fc7f7f82b5e1e9fd643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10495-022-01802-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10495-022-01802-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36652128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Kun</creatorcontrib><creatorcontrib>Lan, Dongfeng</creatorcontrib><creatorcontrib>Li, Chunyang</creatorcontrib><creatorcontrib>Liu, Songpo</creatorcontrib><creatorcontrib>Dai, Xiaofang</creatorcontrib><creatorcontrib>Song, Tao</creatorcontrib><creatorcontrib>Wang, Xianyao</creatorcontrib><creatorcontrib>Kong, Qinghong</creatorcontrib><creatorcontrib>He, Zhixu</creatorcontrib><creatorcontrib>Tan, Jun</creatorcontrib><creatorcontrib>Zhang, Jidong</creatorcontrib><title>A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury</title><title>Apoptosis (London)</title><addtitle>Apoptosis</addtitle><addtitle>Apoptosis</addtitle><description>Apoptosis repressor with caspase recruitment domain (ARC) acts as a potent and multifunctional inhibitor of apoptosis, which is mainly expressed in postmitotic cells, including cardiomyocytes. 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This review summarizes the current research progress of ARC in the field of tumorigenesis and ischaemia/reperfusion injury, to provide overall research status and new possibilities for researchers.</description><subject>Apoptosis</subject><subject>Apoptosis - genetics</subject><subject>Apoptosis Regulatory Proteins - metabolism</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calcium (mitochondrial)</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Carcinogenesis - genetics</subject><subject>Cardiomyocytes</subject><subject>Caspase</subject><subject>Caspase Activation and Recruitment Domain</subject><subject>Cell Biology</subject><subject>Cell Transformation, Neoplastic</subject><subject>Circulatory system</subject><subject>Colorectal carcinoma</subject><subject>Disasters</subject><subject>Domains</subject><subject>Humans</subject><subject>Injury prevention</subject><subject>Ischemia</subject><subject>Kidney cancer</subject><subject>Mitochondria</subject><subject>Oncology</subject><subject>Oxidative stress</subject><subject>Recruitment</subject><subject>Renal cell carcinoma</subject><subject>Reperfusion</subject><subject>Reperfusion Injury - 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Academic</collection><jtitle>Apoptosis (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Kun</au><au>Lan, Dongfeng</au><au>Li, Chunyang</au><au>Liu, Songpo</au><au>Dai, Xiaofang</au><au>Song, Tao</au><au>Wang, Xianyao</au><au>Kong, Qinghong</au><au>He, Zhixu</au><au>Tan, Jun</au><au>Zhang, Jidong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury</atitle><jtitle>Apoptosis (London)</jtitle><stitle>Apoptosis</stitle><addtitle>Apoptosis</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>28</volume><issue>3-4</issue><spage>313</spage><epage>325</epage><pages>313-325</pages><issn>1360-8185</issn><eissn>1573-675X</eissn><abstract>Apoptosis repressor with caspase recruitment domain (ARC) acts as a potent and multifunctional inhibitor of apoptosis, which is mainly expressed in postmitotic cells, including cardiomyocytes. ARC is special for its N-terminal caspase recruitment domain and caspase recruitment domain. Due to the powerful inhibition of apoptosis, ARC is mainly reported to act as a cardioprotective factor during ischaemia‒reperfusion (I/R) injury, preventing cardiomyocytes from being devastated by various catastrophes, including oxidative stress, calcium overload, and mitochondrial dysfunction in the circulatory system. However, recent studies have found that ARC also plays a potential regulatory role in tumorigenesis especially in colorectal cancer and renal cell carcinomas, through multiple apoptosis-associated pathways, which remains to be explored in further studies. Therefore, ARC regulates the body and maintains the balance of physiological activities with its interesting duplex. This review summarizes the current research progress of ARC in the field of tumorigenesis and ischaemia/reperfusion injury, to provide overall research status and new possibilities for researchers.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36652128</pmid><doi>10.1007/s10495-022-01802-4</doi><tpages>13</tpages></addata></record> |
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| subjects | Apoptosis Apoptosis - genetics Apoptosis Regulatory Proteins - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Calcium (mitochondrial) Cancer Cancer Research Carcinogenesis - genetics Cardiomyocytes Caspase Caspase Activation and Recruitment Domain Cell Biology Cell Transformation, Neoplastic Circulatory system Colorectal carcinoma Disasters Domains Humans Injury prevention Ischemia Kidney cancer Mitochondria Oncology Oxidative stress Recruitment Renal cell carcinoma Reperfusion Reperfusion Injury - genetics Review Tumorigenesis Virology |
| title | A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury |
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