Cysteine-rich 61(CYR61) alleviates cyclophosphamide-induced proliferation inhibition in ovarian granulosa cells via suppressing NLRP3/caspase1-mediated pyroptosis

Background We investigated the level of Cysteine-rich 61 (CYR61) in premature ovarian failure as well as its regulatory molecular mechanism in this study. Methods and Results Cyclophosphamide (CTX) was used to induce OGCs (rat ovarian granulosa cells) and rats to establish in vivo and in vitro prema...

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Veröffentlicht in:	Human & experimental toxicology 2023-01, Vol.42, p.9603271231152831-9603271231152831
Hauptverfasser:	Xu, Hongxia, Bao, Xiumin, Yang, Junya, Kong, Hanxin, Li, Yan, Sun, Zhiwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biotin Caspase-1 Caspases - metabolism Cell Proliferation Cell viability Cholecystokinin Cyclin-dependent kinase inhibitor p21 Cyclophosphamide Cyclophosphamide - toxicity CYR61 protein Cysteine Cysteine-Rich Protein 61 - genetics Cysteine-Rich Protein 61 - metabolism DNA nucleotidylexotransferase Failure Female Flow cytometry Galactosidase Granulosa cells Granulosa Cells - metabolism GTP-binding protein Histopathology Humans Immunofluorescence Molecular modelling NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Ovaries p53 Protein Primary Ovarian Insufficiency - chemically induced Proteins Pyroptosis Rats Reproductive status Senescence Signal Transduction Staining Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism β-Galactosidase
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