Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis

Ischemia reperfusion (I/R) injury remains a frequent adverse event that accompanies heart transplantation. Oxidative stress and aberrant production of free radicals were regarded as the culprit of cell death and tissue damage in post-transplant IR injury. Mst1 has been identified as a mediator of ox...

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Veröffentlicht in:Biochemical and biophysical research communications 2023-02, Vol.644, p.140-148
Hauptverfasser: Fei, Qi, Liu, Justin, Qiao, Li, Zhang, Meng, Xia, Haidong, Lu, Daoqiang, Wu, Di, Wang, Jun, Li, Riwang, Li, Jie, Yang, Fang, Liu, Dahai, Xie, Baiyi, Hui, Wenqiao, Qian, Ban
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container_title Biochemical and biophysical research communications
container_volume 644
creator Fei, Qi
Liu, Justin
Qiao, Li
Zhang, Meng
Xia, Haidong
Lu, Daoqiang
Wu, Di
Wang, Jun
Li, Riwang
Li, Jie
Yang, Fang
Liu, Dahai
Xie, Baiyi
Hui, Wenqiao
Qian, Ban
description Ischemia reperfusion (I/R) injury remains a frequent adverse event that accompanies heart transplantation. Oxidative stress and aberrant production of free radicals were regarded as the culprit of cell death and tissue damage in post-transplant IR injury. Mst1 has been identified as a mediator of oxidative stress and Nrf2 regulates anti-oxidative enzymes, however, the interaction between Mst1 and Nrf2 anti-oxidative stress pathway remains to be clarified in the event of cardiac IR injury. Herein, the model of ischemia-reperfusion injury in heterotopic heart transplantation mice was firstly established.. We observed that cardiac IR induced upregulation of Mst1 and activation of Nrf2/HO-1pathway in mice receiving heterotopic heart transplantation. Further Cobalt dichloride-induced oxidative stress model of RAW264.7 macrophage cells were then established to mimic cardiac I/R injury, results showed that exposure to CoCl2 induced the upregulation of Mst1 and activation of Keap1/Nrf2 pathway, and genetic ablation of Mst-1 and inhibition of Keap1/Nrf2 pathway aggravated oxidative damage in those cells. Additional in vivo study showed that transfection of Mst1 shRNA spurred ROS generation and worsened cardiac damage in IR mice. Meanwhile, Mst1-KD mice receiving heart transplantation showed markedly downregulation of Nrf2, HO-1 yet upregulation of Keap1, indicating diminished protective effect against tissue damage caused by IR probably owing to the frustration of Keap1/Nrf2 pathway. Taken together, our findings demonstrated the protective effect of Mst1 from cardiac IR injury via triggering Keap1/Nrf2 axis and suppressing ROS generation, which shed light on the promising role of Mst1 in transitional management of IR injury resulted from cardiac transplantation. •Mst1 participates in the regulation of Keap1/Nrf2/HO-1anti-oxidative pathway.•Knockdown of Mst1 augments pathophysiological events of I/R injury in mice via inhibiting Keap1/Nrf2/and HO-1 pathway.•Mst1 play the protective regulatory effect on cardiac IR injury via activation of Nrf2/Keap1 axis.
doi_str_mv 10.1016/j.bbrc.2022.12.087
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Oxidative stress and aberrant production of free radicals were regarded as the culprit of cell death and tissue damage in post-transplant IR injury. Mst1 has been identified as a mediator of oxidative stress and Nrf2 regulates anti-oxidative enzymes, however, the interaction between Mst1 and Nrf2 anti-oxidative stress pathway remains to be clarified in the event of cardiac IR injury. Herein, the model of ischemia-reperfusion injury in heterotopic heart transplantation mice was firstly established.. We observed that cardiac IR induced upregulation of Mst1 and activation of Nrf2/HO-1pathway in mice receiving heterotopic heart transplantation. Further Cobalt dichloride-induced oxidative stress model of RAW264.7 macrophage cells were then established to mimic cardiac I/R injury, results showed that exposure to CoCl2 induced the upregulation of Mst1 and activation of Keap1/Nrf2 pathway, and genetic ablation of Mst-1 and inhibition of Keap1/Nrf2 pathway aggravated oxidative damage in those cells. Additional in vivo study showed that transfection of Mst1 shRNA spurred ROS generation and worsened cardiac damage in IR mice. Meanwhile, Mst1-KD mice receiving heart transplantation showed markedly downregulation of Nrf2, HO-1 yet upregulation of Keap1, indicating diminished protective effect against tissue damage caused by IR probably owing to the frustration of Keap1/Nrf2 pathway. Taken together, our findings demonstrated the protective effect of Mst1 from cardiac IR injury via triggering Keap1/Nrf2 axis and suppressing ROS generation, which shed light on the promising role of Mst1 in transitional management of IR injury resulted from cardiac transplantation. •Mst1 participates in the regulation of Keap1/Nrf2/HO-1anti-oxidative pathway.•Knockdown of Mst1 augments pathophysiological events of I/R injury in mice via inhibiting Keap1/Nrf2/and HO-1 pathway.•Mst1 play the protective regulatory effect on cardiac IR injury via activation of Nrf2/Keap1 axis.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2022.12.087</identifier><identifier>PMID: 36646002</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Heart transplantation ; Heart Transplantation - adverse effects ; Ischemia reperfusion (I/R) injury ; Kelch-Like ECH-Associated Protein 1 - metabolism ; Mice ; Mst1 ; Myocardial Reperfusion Injury - metabolism ; NF-E2-Related Factor 2 - genetics ; NF-E2-Related Factor 2 - metabolism ; Nrf2 ; Protein Serine-Threonine Kinases - metabolism ; Reactive Oxygen Species - metabolism ; Reperfusion Injury - metabolism ; ROS production</subject><ispartof>Biochemical and biophysical research communications, 2023-02, Vol.644, p.140-148</ispartof><rights>2023 The Authors</rights><rights>Copyright © 2023 The Authors. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-3476a37a67df9230bad772f980f7ffa44411e80575c8a677d097ab1d3e3a76ed3</citedby><cites>FETCH-LOGICAL-c400t-3476a37a67df9230bad772f980f7ffa44411e80575c8a677d097ab1d3e3a76ed3</cites><orcidid>0000-0002-5206-6349 ; 0000-0002-3520-1721</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2022.12.087$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36646002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fei, Qi</creatorcontrib><creatorcontrib>Liu, Justin</creatorcontrib><creatorcontrib>Qiao, Li</creatorcontrib><creatorcontrib>Zhang, Meng</creatorcontrib><creatorcontrib>Xia, Haidong</creatorcontrib><creatorcontrib>Lu, Daoqiang</creatorcontrib><creatorcontrib>Wu, Di</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Li, Riwang</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Yang, Fang</creatorcontrib><creatorcontrib>Liu, Dahai</creatorcontrib><creatorcontrib>Xie, Baiyi</creatorcontrib><creatorcontrib>Hui, Wenqiao</creatorcontrib><creatorcontrib>Qian, Ban</creatorcontrib><title>Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Ischemia reperfusion (I/R) injury remains a frequent adverse event that accompanies heart transplantation. Oxidative stress and aberrant production of free radicals were regarded as the culprit of cell death and tissue damage in post-transplant IR injury. Mst1 has been identified as a mediator of oxidative stress and Nrf2 regulates anti-oxidative enzymes, however, the interaction between Mst1 and Nrf2 anti-oxidative stress pathway remains to be clarified in the event of cardiac IR injury. Herein, the model of ischemia-reperfusion injury in heterotopic heart transplantation mice was firstly established.. We observed that cardiac IR induced upregulation of Mst1 and activation of Nrf2/HO-1pathway in mice receiving heterotopic heart transplantation. Further Cobalt dichloride-induced oxidative stress model of RAW264.7 macrophage cells were then established to mimic cardiac I/R injury, results showed that exposure to CoCl2 induced the upregulation of Mst1 and activation of Keap1/Nrf2 pathway, and genetic ablation of Mst-1 and inhibition of Keap1/Nrf2 pathway aggravated oxidative damage in those cells. Additional in vivo study showed that transfection of Mst1 shRNA spurred ROS generation and worsened cardiac damage in IR mice. Meanwhile, Mst1-KD mice receiving heart transplantation showed markedly downregulation of Nrf2, HO-1 yet upregulation of Keap1, indicating diminished protective effect against tissue damage caused by IR probably owing to the frustration of Keap1/Nrf2 pathway. 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Oxidative stress and aberrant production of free radicals were regarded as the culprit of cell death and tissue damage in post-transplant IR injury. Mst1 has been identified as a mediator of oxidative stress and Nrf2 regulates anti-oxidative enzymes, however, the interaction between Mst1 and Nrf2 anti-oxidative stress pathway remains to be clarified in the event of cardiac IR injury. Herein, the model of ischemia-reperfusion injury in heterotopic heart transplantation mice was firstly established.. We observed that cardiac IR induced upregulation of Mst1 and activation of Nrf2/HO-1pathway in mice receiving heterotopic heart transplantation. Further Cobalt dichloride-induced oxidative stress model of RAW264.7 macrophage cells were then established to mimic cardiac I/R injury, results showed that exposure to CoCl2 induced the upregulation of Mst1 and activation of Keap1/Nrf2 pathway, and genetic ablation of Mst-1 and inhibition of Keap1/Nrf2 pathway aggravated oxidative damage in those cells. Additional in vivo study showed that transfection of Mst1 shRNA spurred ROS generation and worsened cardiac damage in IR mice. Meanwhile, Mst1-KD mice receiving heart transplantation showed markedly downregulation of Nrf2, HO-1 yet upregulation of Keap1, indicating diminished protective effect against tissue damage caused by IR probably owing to the frustration of Keap1/Nrf2 pathway. Taken together, our findings demonstrated the protective effect of Mst1 from cardiac IR injury via triggering Keap1/Nrf2 axis and suppressing ROS generation, which shed light on the promising role of Mst1 in transitional management of IR injury resulted from cardiac transplantation. •Mst1 participates in the regulation of Keap1/Nrf2/HO-1anti-oxidative pathway.•Knockdown of Mst1 augments pathophysiological events of I/R injury in mice via inhibiting Keap1/Nrf2/and HO-1 pathway.•Mst1 play the protective regulatory effect on cardiac IR injury via activation of Nrf2/Keap1 axis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>36646002</pmid><doi>10.1016/j.bbrc.2022.12.087</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5206-6349</orcidid><orcidid>https://orcid.org/0000-0002-3520-1721</orcidid><oa>free_for_read</oa></addata></record>
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subjects Animals
Heart transplantation
Heart Transplantation - adverse effects
Ischemia reperfusion (I/R) injury
Kelch-Like ECH-Associated Protein 1 - metabolism
Mice
Mst1
Myocardial Reperfusion Injury - metabolism
NF-E2-Related Factor 2 - genetics
NF-E2-Related Factor 2 - metabolism
Nrf2
Protein Serine-Threonine Kinases - metabolism
Reactive Oxygen Species - metabolism
Reperfusion Injury - metabolism
ROS production
title Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis
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