Intracranial Self-stimulation of the Medial Forebrain Bundle Ameliorates Memory Disturbances and Pathological Hallmarks in an Alzheimer’s Disease Model by Intracerebral Administration of Amyloid-β in Rats

[Display omitted] •MFB-ICSS reverses spatial memory deficits in Aβ-injected rats.•MFB-ICSS reserves ptau levels in CA1 and enthorhinal cortex in Aβ rats.•DBN levels in temporal regions are restored in MFB-ICSS treated Aβ rats.•DBN levels and behavioral afectation correlations change after MFB-ICSS....

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Veröffentlicht in:	Neuroscience 2023-02, Vol.512, p.16-31
Hauptverfasser:	Puig-Parnau, Irene, Garcia-Brito, Soleil, Vila-Soles, Laia, Riberas, Andrea, Aldavert-Vera, Laura, Segura-Torres, Pilar, Kádár, Elisabet, Huguet, Gemma
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - therapy Alzheimer’s disease Amyloid beta-Peptides amyloid-β Animals deep brain stimulation Disease Models, Animal Electric Stimulation Therapy - methods intracranial self-stimulation Male medial forebrain bundle Medial Forebrain Bundle - physiology Memory Disorders - therapy Rats Rats, Wistar Spatial Memory - physiology
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