Incidence of cutaneous graft‐versus‐host disease in a Singapore academic medical centre – A retrospective cohort study
Background Cutaneous graft‐versus‐host disease (GVHD) is common in allogeneic haematopoietic stem cell transplantation. HLA mismatch is the most significant determinant of GVHD. Our study aimed to compare the incidence of cutaneous GVHD haploidentical (Haplo) and matched donors in an Asian populatio...
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| Veröffentlicht in: | Australasian journal of dermatology 2023-02, Vol.64 (1), p.e26-e33 |
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| container_title | Australasian journal of dermatology |
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| creator | Tan, Wen Hao Ho, Aloysius Kadir, Hanis Abdul Zin, That Khaing Jordan, Hwang Chung Cheng Lee, Haur Yueh Pang, Shiu Ming Yeo, Yi Wei Choo, Karen Jui Lin Oh, Choon Chiat |
| description | Background
Cutaneous graft‐versus‐host disease (GVHD) is common in allogeneic haematopoietic stem cell transplantation. HLA mismatch is the most significant determinant of GVHD. Our study aimed to compare the incidence of cutaneous GVHD haploidentical (Haplo) and matched donors in an Asian population.
Methods
Retrospective cohort study of the 2015–2019 bone marrow transplant registry was conducted in a transplant centre. We compared the incidence of cutaneous GVHD in Haplo with allogeneic matched unrelated donor (MUD) and matched–sibling donor (MSD) transplant recipients. Secondary objectives include acute and chronic GVHD incidence, dermatology referrals, and histological findings.
Results
One hundred and seventy‐nine out of 203 cases were reviewed; 17 (9.5%) Haplo, 80 (44.7%) MUDs and 82 (45.8%) MSDs. The median follow‐up for Haplo, MUD and MSD was 15.2, 34.2 and 35.7 months, respectively. Haplo had a higher cumulative incidence of cutaneous GVHD than MUD and MSD (p = 0.053). Chronic GVHD was only reported in MSD. The most common histology was vacuolar interface changes (13 [44.8%]) with a wide range of onset post‐transplant (19–456 days).
Conclusions
Haplo donors may have a higher GVHD incidence than MUD and MSD in our predominantly Asian cohort. This information may be helpful when counselling patients pre‐transplant. Further prospective studies are required. |
| doi_str_mv | 10.1111/ajd.13980 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2766063709</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2766063709</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3130-16020afe4006916e8bc3ddbb18e7e88acacb41ccf4ee79b95bbc14da31970efe3</originalsourceid><addsrcrecordid>eNp1kc1u1DAQx62qiC6FQ1-gstQLHNKO146THFflq6gSB-AcOeNJ61U23tpO0Uoc-ghIvGGfBENaDpWYy4xGP_3n48_YkYBTkePMrO2pkE0Ne2whlIICGg37bAEAqqhlDQfsRYxrACFFWT5nB1JrVaolLNiPixGdpRGJ-57jlMxIfor8Kpg-3d_9vKUQp5iLax8Tty6SicTdyA3_4sYrs_WBuEFjaeOQb8g6NANHGlPu39_94iseKAUft4TJ3RJHf-1D4jFNdveSPevNEOnVQz5k396_-3r-sbj8_OHifHVZoBQSCqFhCaYnBaAboanuUFrbdaKmiuo6T8dOCcReEVVN15Rdh0JZI0VTAfUkD9nrWXcb_M1EMbUbF5GGYT62XVZag5YVNBk9eYKu_RTGvF2mKq2grEFm6s1MYb4sBurbbXAbE3atgPaPJW22pP1rSWaPHxSnLv_nH_noQQbOZuC7G2j3f6V29entLPkbfLSZ2Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2776405803</pqid></control><display><type>article</type><title>Incidence of cutaneous graft‐versus‐host disease in a Singapore academic medical centre – A retrospective cohort study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Tan, Wen Hao ; Ho, Aloysius ; Kadir, Hanis Abdul ; Zin, That Khaing ; Jordan, Hwang Chung Cheng ; Lee, Haur Yueh ; Pang, Shiu Ming ; Yeo, Yi Wei ; Choo, Karen Jui Lin ; Oh, Choon Chiat</creator><creatorcontrib>Tan, Wen Hao ; Ho, Aloysius ; Kadir, Hanis Abdul ; Zin, That Khaing ; Jordan, Hwang Chung Cheng ; Lee, Haur Yueh ; Pang, Shiu Ming ; Yeo, Yi Wei ; Choo, Karen Jui Lin ; Oh, Choon Chiat</creatorcontrib><description>Background
Cutaneous graft‐versus‐host disease (GVHD) is common in allogeneic haematopoietic stem cell transplantation. HLA mismatch is the most significant determinant of GVHD. Our study aimed to compare the incidence of cutaneous GVHD haploidentical (Haplo) and matched donors in an Asian population.
Methods
Retrospective cohort study of the 2015–2019 bone marrow transplant registry was conducted in a transplant centre. We compared the incidence of cutaneous GVHD in Haplo with allogeneic matched unrelated donor (MUD) and matched–sibling donor (MSD) transplant recipients. Secondary objectives include acute and chronic GVHD incidence, dermatology referrals, and histological findings.
Results
One hundred and seventy‐nine out of 203 cases were reviewed; 17 (9.5%) Haplo, 80 (44.7%) MUDs and 82 (45.8%) MSDs. The median follow‐up for Haplo, MUD and MSD was 15.2, 34.2 and 35.7 months, respectively. Haplo had a higher cumulative incidence of cutaneous GVHD than MUD and MSD (p = 0.053). Chronic GVHD was only reported in MSD. The most common histology was vacuolar interface changes (13 [44.8%]) with a wide range of onset post‐transplant (19–456 days).
Conclusions
Haplo donors may have a higher GVHD incidence than MUD and MSD in our predominantly Asian cohort. This information may be helpful when counselling patients pre‐transplant. Further prospective studies are required.</description><identifier>ISSN: 0004-8380</identifier><identifier>EISSN: 1440-0960</identifier><identifier>DOI: 10.1111/ajd.13980</identifier><identifier>PMID: 36645420</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Antigenic determinants ; bone marrow ; Bone marrow transplantation ; Cohort analysis ; cutaneous GVHD ; Donors ; graft versus host ; Graft vs Host Disease - epidemiology ; Graft vs Host Disease - etiology ; Graft-versus-host reaction ; haploidentical ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic stem cells ; Histology ; Humans ; Incidence ; oncology ; Population studies ; Retrospective Studies ; Singapore - epidemiology ; Stem cell transplantation ; transplant ; Transplants & implants</subject><ispartof>Australasian journal of dermatology, 2023-02, Vol.64 (1), p.e26-e33</ispartof><rights>2023 Australasian College of Dermatologists.</rights><rights>Copyright © 2023 The Australasian College of Dermatologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3130-16020afe4006916e8bc3ddbb18e7e88acacb41ccf4ee79b95bbc14da31970efe3</cites><orcidid>0000-0002-4769-8595 ; 0000-0002-7783-4842</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fajd.13980$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fajd.13980$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36645420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Wen Hao</creatorcontrib><creatorcontrib>Ho, Aloysius</creatorcontrib><creatorcontrib>Kadir, Hanis Abdul</creatorcontrib><creatorcontrib>Zin, That Khaing</creatorcontrib><creatorcontrib>Jordan, Hwang Chung Cheng</creatorcontrib><creatorcontrib>Lee, Haur Yueh</creatorcontrib><creatorcontrib>Pang, Shiu Ming</creatorcontrib><creatorcontrib>Yeo, Yi Wei</creatorcontrib><creatorcontrib>Choo, Karen Jui Lin</creatorcontrib><creatorcontrib>Oh, Choon Chiat</creatorcontrib><title>Incidence of cutaneous graft‐versus‐host disease in a Singapore academic medical centre – A retrospective cohort study</title><title>Australasian journal of dermatology</title><addtitle>Australas J Dermatol</addtitle><description>Background
Cutaneous graft‐versus‐host disease (GVHD) is common in allogeneic haematopoietic stem cell transplantation. HLA mismatch is the most significant determinant of GVHD. Our study aimed to compare the incidence of cutaneous GVHD haploidentical (Haplo) and matched donors in an Asian population.
Methods
Retrospective cohort study of the 2015–2019 bone marrow transplant registry was conducted in a transplant centre. We compared the incidence of cutaneous GVHD in Haplo with allogeneic matched unrelated donor (MUD) and matched–sibling donor (MSD) transplant recipients. Secondary objectives include acute and chronic GVHD incidence, dermatology referrals, and histological findings.
Results
One hundred and seventy‐nine out of 203 cases were reviewed; 17 (9.5%) Haplo, 80 (44.7%) MUDs and 82 (45.8%) MSDs. The median follow‐up for Haplo, MUD and MSD was 15.2, 34.2 and 35.7 months, respectively. Haplo had a higher cumulative incidence of cutaneous GVHD than MUD and MSD (p = 0.053). Chronic GVHD was only reported in MSD. The most common histology was vacuolar interface changes (13 [44.8%]) with a wide range of onset post‐transplant (19–456 days).
Conclusions
Haplo donors may have a higher GVHD incidence than MUD and MSD in our predominantly Asian cohort. This information may be helpful when counselling patients pre‐transplant. Further prospective studies are required.</description><subject>Antigenic determinants</subject><subject>bone marrow</subject><subject>Bone marrow transplantation</subject><subject>Cohort analysis</subject><subject>cutaneous GVHD</subject><subject>Donors</subject><subject>graft versus host</subject><subject>Graft vs Host Disease - epidemiology</subject><subject>Graft vs Host Disease - etiology</subject><subject>Graft-versus-host reaction</subject><subject>haploidentical</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic stem cells</subject><subject>Histology</subject><subject>Humans</subject><subject>Incidence</subject><subject>oncology</subject><subject>Population studies</subject><subject>Retrospective Studies</subject><subject>Singapore - epidemiology</subject><subject>Stem cell transplantation</subject><subject>transplant</subject><subject>Transplants & implants</subject><issn>0004-8380</issn><issn>1440-0960</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAQx62qiC6FQ1-gstQLHNKO146THFflq6gSB-AcOeNJ61U23tpO0Uoc-ghIvGGfBENaDpWYy4xGP_3n48_YkYBTkePMrO2pkE0Ne2whlIICGg37bAEAqqhlDQfsRYxrACFFWT5nB1JrVaolLNiPixGdpRGJ-57jlMxIfor8Kpg-3d_9vKUQp5iLax8Tty6SicTdyA3_4sYrs_WBuEFjaeOQb8g6NANHGlPu39_94iseKAUft4TJ3RJHf-1D4jFNdveSPevNEOnVQz5k396_-3r-sbj8_OHifHVZoBQSCqFhCaYnBaAboanuUFrbdaKmiuo6T8dOCcReEVVN15Rdh0JZI0VTAfUkD9nrWXcb_M1EMbUbF5GGYT62XVZag5YVNBk9eYKu_RTGvF2mKq2grEFm6s1MYb4sBurbbXAbE3atgPaPJW22pP1rSWaPHxSnLv_nH_noQQbOZuC7G2j3f6V29entLPkbfLSZ2Q</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Tan, Wen Hao</creator><creator>Ho, Aloysius</creator><creator>Kadir, Hanis Abdul</creator><creator>Zin, That Khaing</creator><creator>Jordan, Hwang Chung Cheng</creator><creator>Lee, Haur Yueh</creator><creator>Pang, Shiu Ming</creator><creator>Yeo, Yi Wei</creator><creator>Choo, Karen Jui Lin</creator><creator>Oh, Choon Chiat</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4769-8595</orcidid><orcidid>https://orcid.org/0000-0002-7783-4842</orcidid></search><sort><creationdate>202302</creationdate><title>Incidence of cutaneous graft‐versus‐host disease in a Singapore academic medical centre – A retrospective cohort study</title><author>Tan, Wen Hao ; Ho, Aloysius ; Kadir, Hanis Abdul ; Zin, That Khaing ; Jordan, Hwang Chung Cheng ; Lee, Haur Yueh ; Pang, Shiu Ming ; Yeo, Yi Wei ; Choo, Karen Jui Lin ; Oh, Choon Chiat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3130-16020afe4006916e8bc3ddbb18e7e88acacb41ccf4ee79b95bbc14da31970efe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antigenic determinants</topic><topic>bone marrow</topic><topic>Bone marrow transplantation</topic><topic>Cohort analysis</topic><topic>cutaneous GVHD</topic><topic>Donors</topic><topic>graft versus host</topic><topic>Graft vs Host Disease - epidemiology</topic><topic>Graft vs Host Disease - etiology</topic><topic>Graft-versus-host reaction</topic><topic>haploidentical</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hematopoietic stem cells</topic><topic>Histology</topic><topic>Humans</topic><topic>Incidence</topic><topic>oncology</topic><topic>Population studies</topic><topic>Retrospective Studies</topic><topic>Singapore - epidemiology</topic><topic>Stem cell transplantation</topic><topic>transplant</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Wen Hao</creatorcontrib><creatorcontrib>Ho, Aloysius</creatorcontrib><creatorcontrib>Kadir, Hanis Abdul</creatorcontrib><creatorcontrib>Zin, That Khaing</creatorcontrib><creatorcontrib>Jordan, Hwang Chung Cheng</creatorcontrib><creatorcontrib>Lee, Haur Yueh</creatorcontrib><creatorcontrib>Pang, Shiu Ming</creatorcontrib><creatorcontrib>Yeo, Yi Wei</creatorcontrib><creatorcontrib>Choo, Karen Jui Lin</creatorcontrib><creatorcontrib>Oh, Choon Chiat</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Australasian journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Wen Hao</au><au>Ho, Aloysius</au><au>Kadir, Hanis Abdul</au><au>Zin, That Khaing</au><au>Jordan, Hwang Chung Cheng</au><au>Lee, Haur Yueh</au><au>Pang, Shiu Ming</au><au>Yeo, Yi Wei</au><au>Choo, Karen Jui Lin</au><au>Oh, Choon Chiat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of cutaneous graft‐versus‐host disease in a Singapore academic medical centre – A retrospective cohort study</atitle><jtitle>Australasian journal of dermatology</jtitle><addtitle>Australas J Dermatol</addtitle><date>2023-02</date><risdate>2023</risdate><volume>64</volume><issue>1</issue><spage>e26</spage><epage>e33</epage><pages>e26-e33</pages><issn>0004-8380</issn><eissn>1440-0960</eissn><abstract>Background
Cutaneous graft‐versus‐host disease (GVHD) is common in allogeneic haematopoietic stem cell transplantation. HLA mismatch is the most significant determinant of GVHD. Our study aimed to compare the incidence of cutaneous GVHD haploidentical (Haplo) and matched donors in an Asian population.
Methods
Retrospective cohort study of the 2015–2019 bone marrow transplant registry was conducted in a transplant centre. We compared the incidence of cutaneous GVHD in Haplo with allogeneic matched unrelated donor (MUD) and matched–sibling donor (MSD) transplant recipients. Secondary objectives include acute and chronic GVHD incidence, dermatology referrals, and histological findings.
Results
One hundred and seventy‐nine out of 203 cases were reviewed; 17 (9.5%) Haplo, 80 (44.7%) MUDs and 82 (45.8%) MSDs. The median follow‐up for Haplo, MUD and MSD was 15.2, 34.2 and 35.7 months, respectively. Haplo had a higher cumulative incidence of cutaneous GVHD than MUD and MSD (p = 0.053). Chronic GVHD was only reported in MSD. The most common histology was vacuolar interface changes (13 [44.8%]) with a wide range of onset post‐transplant (19–456 days).
Conclusions
Haplo donors may have a higher GVHD incidence than MUD and MSD in our predominantly Asian cohort. This information may be helpful when counselling patients pre‐transplant. Further prospective studies are required.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36645420</pmid><doi>10.1111/ajd.13980</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4769-8595</orcidid><orcidid>https://orcid.org/0000-0002-7783-4842</orcidid></addata></record> |
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| ispartof | Australasian journal of dermatology, 2023-02, Vol.64 (1), p.e26-e33 |
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| subjects | Antigenic determinants bone marrow Bone marrow transplantation Cohort analysis cutaneous GVHD Donors graft versus host Graft vs Host Disease - epidemiology Graft vs Host Disease - etiology Graft-versus-host reaction haploidentical Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Histology Humans Incidence oncology Population studies Retrospective Studies Singapore - epidemiology Stem cell transplantation transplant Transplants & implants |
| title | Incidence of cutaneous graft‐versus‐host disease in a Singapore academic medical centre – A retrospective cohort study |
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