Metal ions doping effect on the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite
The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing. The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug rel...
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| Veröffentlicht in: | Carbohydrate polymers 2023-03, Vol.304, p.120486-120486, Article 120486 |
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| container_title | Carbohydrate polymers |
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| creator | Sukhodub, Liudmyla Kumeda, Mariia Sukhodub, Leonid Bielai, Volodymyr Lyndin, Mykola |
| description | The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing. The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing are shown. Me-containing samples have a lower sorption capacity, than a commercial Kaltostat, however, a much lower degree of their dehydration provides a longer wound wet. The Men+ presence lowers the environmental pH to slightly acidic values promoting healing. Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence. The material promotes the proliferation of the fibroblasts, an increase of collagen fibres, and new arterial and venous capillaries, indicating the intensity of the healing process.
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| doi_str_mv | 10.1016/j.carbpol.2022.120486 |
| format | Article |
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[Display omitted]</description><subject>Alginate</subject><subject>Alginates - chemistry</subject><subject>Alginates - pharmacology</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibacterial activity</subject><subject>Chitosan - chemistry</subject><subject>Chitosan - pharmacology</subject><subject>Dehydration</subject><subject>Escherichia coli</subject><subject>HPLC</subject><subject>Humans</subject><subject>Hydroxyapatite</subject><subject>Metal ions</subject><subject>Metals</subject><subject>Staphylococcus aureus</subject><subject>Wound dressing</subject><subject>Wound Healing</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2PFCEQhonRuOPqT9Bw9GCPFM2XJ2M2fiVrvOiZ0FDsMKGbtulZs_9eJj16lUNBJe9bL_UQ8hLYHhiot8e9d8swl7znjPM9cCaMekR2YPS7DnohHpMdAyE6o0BfkWe1Hlk7CthTctUrJQCM3JH7b7i6TFOZKg1lTtMdxRjRr7RMdD0gnQ8PNfniDzgm7_Ib6qY1tedShrS1gf4up1YP6PLZPy8lpoyVlkhdvkuTW7EbXMVAfRnnUtOKz8mT6HLFF5f7mvz89PHHzZfu9vvnrzcfbjsvgK-dMj46pjTovvfouA4igAHpBi4kd6qHEDRCjMYZqYTppRSuNwyCkkG62F-T19vc9qlfJ6yrHVP1mLObsJyq5VpJrY3ipknlJm2r1bpgtPOSRrc8WGD2jNwe7QW5PSO3G_Lme3WJOA0jhn-uv4yb4P0mwLbofcLFVp9w8hjS0kDbUNJ_Iv4AXR-WAA</recordid><startdate>20230315</startdate><enddate>20230315</enddate><creator>Sukhodub, Liudmyla</creator><creator>Kumeda, Mariia</creator><creator>Sukhodub, Leonid</creator><creator>Bielai, Volodymyr</creator><creator>Lyndin, Mykola</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230315</creationdate><title>Metal ions doping effect on the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite</title><author>Sukhodub, Liudmyla ; Kumeda, Mariia ; Sukhodub, Leonid ; Bielai, Volodymyr ; Lyndin, Mykola</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-68cfa0671733cea27d4d1815ab2452a631dd7e1ff8a856483554a3801d65d5af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alginate</topic><topic>Alginates - chemistry</topic><topic>Alginates - pharmacology</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antibacterial activity</topic><topic>Chitosan - chemistry</topic><topic>Chitosan - pharmacology</topic><topic>Dehydration</topic><topic>Escherichia coli</topic><topic>HPLC</topic><topic>Humans</topic><topic>Hydroxyapatite</topic><topic>Metal ions</topic><topic>Metals</topic><topic>Staphylococcus aureus</topic><topic>Wound dressing</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sukhodub, Liudmyla</creatorcontrib><creatorcontrib>Kumeda, Mariia</creatorcontrib><creatorcontrib>Sukhodub, Leonid</creatorcontrib><creatorcontrib>Bielai, Volodymyr</creatorcontrib><creatorcontrib>Lyndin, Mykola</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sukhodub, Liudmyla</au><au>Kumeda, Mariia</au><au>Sukhodub, Leonid</au><au>Bielai, Volodymyr</au><au>Lyndin, Mykola</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metal ions doping effect on the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2023-03-15</date><risdate>2023</risdate><volume>304</volume><spage>120486</spage><epage>120486</epage><pages>120486-120486</pages><artnum>120486</artnum><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing. The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing are shown. Me-containing samples have a lower sorption capacity, than a commercial Kaltostat, however, a much lower degree of their dehydration provides a longer wound wet. The Men+ presence lowers the environmental pH to slightly acidic values promoting healing. Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence. The material promotes the proliferation of the fibroblasts, an increase of collagen fibres, and new arterial and venous capillaries, indicating the intensity of the healing process.
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| ispartof | Carbohydrate polymers, 2023-03, Vol.304, p.120486-120486, Article 120486 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alginate Alginates - chemistry Alginates - pharmacology Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Infective Agents - pharmacology Antibacterial activity Chitosan - chemistry Chitosan - pharmacology Dehydration Escherichia coli HPLC Humans Hydroxyapatite Metal ions Metals Staphylococcus aureus Wound dressing Wound Healing |
| title | Metal ions doping effect on the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite |
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