Corylin ameliorates chronic ulcerative colitis via regulating the gut–brain axis and promoting 5-hydroxytryptophan production in the colon

•Corylin alleviates colonic inflammation and neuroinflammation in chronic UC mice.•Corylin improves intestinal mucosal barrier and blood–brain barrier damage.•Corylin reverses level changes of neurotransmitters in the colon, serum, and brain of chronic UC mice.•Binding of corylin to 5-HTPDC induced...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2023-02, Vol.110, p.154651-154651, Article 154651
Hauptverfasser:	Wang, Zhao-Jing, Chen, Li-Hua, Xu, Jing, Xu, Qing-Xia, Xu, Wei, Yang, Xiu-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	5-hydroxytryptophan 5-Hydroxytryptophan - pharmacology Animals Brain-Gut Axis Chromatography, Liquid Chronic ulcerative colitis Colitis - chemically induced Colitis - drug therapy Colitis, Ulcerative - chemically induced Colitis, Ulcerative - drug therapy Colon Corylin Dextran Sulfate Disease Models, Animal Flavonoids Gut–brain axis Inflammation Mice Mice, Inbred C57BL Molecular Docking Simulation RNA, Ribosomal, 16S Serotonin Tandem Mass Spectrometry
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