Stress estimation by the prefrontal cortex asymmetry: Study on fNIRS signals

Functional near-infrared spectroscopy (fNIRS) is a non-invasive technique frequently used to measure the brain hemodynamic activity in applications to evaluate affective disorders and stress. Using two wavelengths of light, it is possible to monitor relative changes in the concentrations of oxyhemoglobin and deoxyhemoglobin. Besides, the spatial asymmetry in the prefrontal cortex activity has been correlated with the brain response to stressful situations. We measured prefrontal cortex activity with a NIRS multi-distance device during a baseline period, under stressful conditions (e.g., social stress), and after a recovery phase. We calculated a laterality index for the contaminated brain signal and for the brain signal where we removed the influence of extracerebral hemodynamic activity by using a short channel. There was a significant right lateralization during stress when using the contaminated signals, consistent with previous investigations, but this significant difference disappeared using the corrected signals. Indeed, exploration of the susceptibility to contamination of the different channels showed non-homogeneous spatial patterns, which would hint at detection of stress from extracerebral activity from the forehead. There was no recovery phase between the social and the arithmetic stressor, a cumulative effect was not considered. Extracerebral hemodynamic activity provided insights into the pertinence of short channel corrections in fNIRS studies dealing with emotions. It is important to consider this issue in clinical applications including modern monitoring systems based on fNIRS technique to assess emotional states in affective disorders. •Stress increases are captured by fNIRS optodes on the forehead.•Extracerebral activity contributes to the prefrontal cortex (PFC) asymmetry index.•Heterogeneous extracerebral activity impacts fNIRS sensitivity to stress recovery.