Specific preadaptations of Rhodococcus equi cooperate with its Virulence‐associated protein A during macrophage infection

Gram‐positive Rhodococcus equi (Prescotella equi) is a lung pathogen of foals and immunocompromised humans. Intra‐macrophage multiplication requires production of the bacterial Virulence‐associated protein A (VapA) which is released into the phagosome lumen. VapA pH‐neutralizes intracellular compart...

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Veröffentlicht in:	Molecular microbiology 2023-03, Vol.119 (3), p.285-301
Hauptverfasser:	Haubenthal, Thomas, Hansen, Philipp, Krämer, Ina, Gindt, Mélanie, Jünger‐Leif, Alexandra, Utermöhlen, Olaf, Haas, Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Bacterial Proteins Horses Humans Infections Lysosomes Macrophages Macrophages - microbiology Multiplication Mycobacterium phagosome Protein A Proteins resistance Rhodococcus Rhodococcus equi Rhodococcus equi - genetics Rhodococcus equi - metabolism Staphylococcal Protein A - metabolism vaccination Vaccine development Vaccines vacuole Virulence Virulence Factors - metabolism
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