Preparation of a bioactive and degradable poly( ε-caprolactone)/silica hybrid through a sol–gel method
A bioactive and degradable poly( ε-caprolactone)/silica hybrid was synthesized for the application as a bone substitute. Triethoxysilane end capped poly( ε-caprolactone) was prepared by the reaction with α, ω-hydroxyl poly( ε-caprolactone) and 3-isocyanatopropyl triethoxysilane using 1,4-diazabicycl...
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| Veröffentlicht in: | Biomaterials 2002-12, Vol.23 (24), p.4915-4921 |
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| container_title | Biomaterials |
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| creator | Rhee, Sang-Hoon Choi, Je-Yong Kim, Hyun-Man |
| description | A bioactive and degradable poly(
ε-caprolactone)/silica hybrid was synthesized for the application as a bone substitute. Triethoxysilane end capped poly(
ε-caprolactone) was prepared by the reaction with
α,
ω-hydroxyl poly(
ε-caprolactone) and 3-isocyanatopropyl triethoxysilane using 1,4-diazabicyclo[2,2,2,]octane as a catalyst. It was then co-condensed with tetraethyl orthosilicate and calcium nitrate tetrahydrate
via a sol–gel method. The bioactivity of the poly(
ε-caprolactone)/silica hybrid was assessed using simulated body fluid and low crystalline apatite was successfully formed on its surface after soaking for 1 week at 36.5°C. Its biodegradability was evaluated in the phosphate buffered saline and the degradability was mostly come from the poly(
ε-caprolactone) phase in the hybrid. It means that this hybrid is likely to be applicable to a bioactive and degradable bone substitute. |
| doi_str_mv | 10.1016/S0142-9612(02)00251-X |
| format | Article |
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ε-caprolactone)/silica hybrid was synthesized for the application as a bone substitute. Triethoxysilane end capped poly(
ε-caprolactone) was prepared by the reaction with
α,
ω-hydroxyl poly(
ε-caprolactone) and 3-isocyanatopropyl triethoxysilane using 1,4-diazabicyclo[2,2,2,]octane as a catalyst. It was then co-condensed with tetraethyl orthosilicate and calcium nitrate tetrahydrate
via a sol–gel method. The bioactivity of the poly(
ε-caprolactone)/silica hybrid was assessed using simulated body fluid and low crystalline apatite was successfully formed on its surface after soaking for 1 week at 36.5°C. Its biodegradability was evaluated in the phosphate buffered saline and the degradability was mostly come from the poly(
ε-caprolactone) phase in the hybrid. It means that this hybrid is likely to be applicable to a bioactive and degradable bone substitute.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/S0142-9612(02)00251-X</identifier><identifier>PMID: 12361633</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Bioactivity ; Biocompatible Materials ; Biodegradability ; Biodegradation, Environmental ; Bone Substitutes ; Humans ; Hybrid ; Hydrogen-Ion Concentration ; Hydrolysis ; Microscopy, Electron, Scanning ; Models, Chemical ; Poly( ε-caprolactone) ; Polyesters - chemistry ; Silica ; Silicon - chemistry ; Spectroscopy, Fourier Transform Infrared ; Time Factors</subject><ispartof>Biomaterials, 2002-12, Vol.23 (24), p.4915-4921</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>Copyright 2002 Elsevier Science Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-e6e4f84baf7f2e066504e2868e31ba9a2a482a8250e5862d12e4d2e33d54bf153</citedby><cites>FETCH-LOGICAL-c572t-e6e4f84baf7f2e066504e2868e31ba9a2a482a8250e5862d12e4d2e33d54bf153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0142-9612(02)00251-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12361633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rhee, Sang-Hoon</creatorcontrib><creatorcontrib>Choi, Je-Yong</creatorcontrib><creatorcontrib>Kim, Hyun-Man</creatorcontrib><title>Preparation of a bioactive and degradable poly( ε-caprolactone)/silica hybrid through a sol–gel method</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>A bioactive and degradable poly(
ε-caprolactone)/silica hybrid was synthesized for the application as a bone substitute. Triethoxysilane end capped poly(
ε-caprolactone) was prepared by the reaction with
α,
ω-hydroxyl poly(
ε-caprolactone) and 3-isocyanatopropyl triethoxysilane using 1,4-diazabicyclo[2,2,2,]octane as a catalyst. It was then co-condensed with tetraethyl orthosilicate and calcium nitrate tetrahydrate
via a sol–gel method. The bioactivity of the poly(
ε-caprolactone)/silica hybrid was assessed using simulated body fluid and low crystalline apatite was successfully formed on its surface after soaking for 1 week at 36.5°C. Its biodegradability was evaluated in the phosphate buffered saline and the degradability was mostly come from the poly(
ε-caprolactone) phase in the hybrid. It means that this hybrid is likely to be applicable to a bioactive and degradable bone substitute.</description><subject>Bioactivity</subject><subject>Biocompatible Materials</subject><subject>Biodegradability</subject><subject>Biodegradation, Environmental</subject><subject>Bone Substitutes</subject><subject>Humans</subject><subject>Hybrid</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hydrolysis</subject><subject>Microscopy, Electron, Scanning</subject><subject>Models, Chemical</subject><subject>Poly( ε-caprolactone)</subject><subject>Polyesters - chemistry</subject><subject>Silica</subject><subject>Silicon - chemistry</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Time Factors</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd1qFDEUgINY7Fp9BCVX0l5Mm5z87MyVlOIfFCqo0LuQSc7sRrKTNZkt7J3v4LP4Gj5En8Ssu-hlhQOHA9_54XyEvODsnDOuLz4xLqHpNIdTBmeMgeLN7SMy4-28bVTH1GMy-4sck6elfGW1ZhKekGMOQnMtxIyEjxnXNtsppJGmgVrah2TdFO6Q2tFTj4tsve0j0nWK21P662fj7DqnWKE04tlFCTE4S5fbPgdPp2VOm8Wyzikp3n__scBIVzgtk39GjgYbCz4_5BPy5e2bz1fvm-ubdx-uLq8bp-YwNahRDq3s7TAfAJnWikmEVrcoeG87C1a2YFtQDFWrwXNA6QGF8Er2A1fihLzaz61HfttgmcwqFIcx2hHTphiYa8kF-y8QOinhQbC-XHRayAqqPehyKiXjYNY5rGzeGs7Mzpr5Y83slBhWY2fN3Na-l4cFm36F_l_XQVMFXu8BrI-7C5hNcQFHhz5kdJPxKTyw4jfTOKh2</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>Rhee, Sang-Hoon</creator><creator>Choi, Je-Yong</creator><creator>Kim, Hyun-Man</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>F28</scope><scope>7QQ</scope><scope>JG9</scope></search><sort><creationdate>20021201</creationdate><title>Preparation of a bioactive and degradable poly( ε-caprolactone)/silica hybrid through a sol–gel method</title><author>Rhee, Sang-Hoon ; Choi, Je-Yong ; Kim, Hyun-Man</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-e6e4f84baf7f2e066504e2868e31ba9a2a482a8250e5862d12e4d2e33d54bf153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Bioactivity</topic><topic>Biocompatible Materials</topic><topic>Biodegradability</topic><topic>Biodegradation, Environmental</topic><topic>Bone Substitutes</topic><topic>Humans</topic><topic>Hybrid</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hydrolysis</topic><topic>Microscopy, Electron, Scanning</topic><topic>Models, Chemical</topic><topic>Poly( ε-caprolactone)</topic><topic>Polyesters - chemistry</topic><topic>Silica</topic><topic>Silicon - chemistry</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rhee, Sang-Hoon</creatorcontrib><creatorcontrib>Choi, Je-Yong</creatorcontrib><creatorcontrib>Kim, Hyun-Man</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Ceramic Abstracts</collection><collection>Materials Research Database</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rhee, Sang-Hoon</au><au>Choi, Je-Yong</au><au>Kim, Hyun-Man</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of a bioactive and degradable poly( ε-caprolactone)/silica hybrid through a sol–gel method</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>23</volume><issue>24</issue><spage>4915</spage><epage>4921</epage><pages>4915-4921</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>A bioactive and degradable poly(
ε-caprolactone)/silica hybrid was synthesized for the application as a bone substitute. Triethoxysilane end capped poly(
ε-caprolactone) was prepared by the reaction with
α,
ω-hydroxyl poly(
ε-caprolactone) and 3-isocyanatopropyl triethoxysilane using 1,4-diazabicyclo[2,2,2,]octane as a catalyst. It was then co-condensed with tetraethyl orthosilicate and calcium nitrate tetrahydrate
via a sol–gel method. The bioactivity of the poly(
ε-caprolactone)/silica hybrid was assessed using simulated body fluid and low crystalline apatite was successfully formed on its surface after soaking for 1 week at 36.5°C. Its biodegradability was evaluated in the phosphate buffered saline and the degradability was mostly come from the poly(
ε-caprolactone) phase in the hybrid. It means that this hybrid is likely to be applicable to a bioactive and degradable bone substitute.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>12361633</pmid><doi>10.1016/S0142-9612(02)00251-X</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 2002-12, Vol.23 (24), p.4915-4921 |
| issn | 0142-9612 1878-5905 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_27641305 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Bioactivity Biocompatible Materials Biodegradability Biodegradation, Environmental Bone Substitutes Humans Hybrid Hydrogen-Ion Concentration Hydrolysis Microscopy, Electron, Scanning Models, Chemical Poly( ε-caprolactone) Polyesters - chemistry Silica Silicon - chemistry Spectroscopy, Fourier Transform Infrared Time Factors |
| title | Preparation of a bioactive and degradable poly( ε-caprolactone)/silica hybrid through a sol–gel method |
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