Quantification of blood–brain barrier water exchange and permeability with multidelay diffusion‐weighted pseudo‐continuous arterial spin labeling

Purpose To present a pulse sequence and mathematical models for quantification of blood–brain barrier water exchange and permeability. Methods Motion‐compensated diffusion‐weighted (MCDW) gradient‐and‐spin echo (GRASE) pseudo‐continuous arterial spin labeling (pCASL) sequence was proposed to acquire...

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Veröffentlicht in:	Magnetic resonance in medicine 2023-05, Vol.89 (5), p.1990-2004
Hauptverfasser:	Shao, Xingfeng, Zhao, Chenyang, Shou, Qinyang, St Lawrence, Keith S., Wang, Danny J. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood flow Blood-brain barrier Blood-Brain Barrier - diagnostic imaging blood–brain barrier (BBB) Brain - blood supply Capillary flow Cerebral blood flow Cerebrovascular Circulation - physiology Diffusion Diffusion barriers diffusion‐weighted arterial spin labeling (DW‐ASL) Group dynamics Humans Labeling Mathematical models Membrane permeability Perfusion Permeability Spatial discrimination Spatial resolution Spin labeling Spin Labels Substantia alba Transit time Water Water exchange water exchange rate (kw) water permeability (PSw)
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