Needle‐free injection system delivery of ZyCoV‐D DNA vaccine demonstrated improved immunogenicity and protective efficacy in rhesus macaques against SARS‐CoV‐2

The apprehension of needles related to injection site pain, risk of transmitting bloodborne pathogens, and effective mass immunization have led to the development of a needle‐free injection system (NFIS). Here, we evaluated the efficacy of the NFIS and needle injection system (NIS) for the delivery...

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Veröffentlicht in:	Journal of medical virology 2023-02, Vol.95 (2), p.e28484-n/a
Hauptverfasser:	Yadav, Pragya D., Kumar, Sanjay, Agarwal, Kshitij, Jain, Mukul, Patil, Dilip R., Maithal, Kapil, Mathapati, Basavaraj, Giri, Suresh, Mohandas, Sreelekshmy, Shete, Anita, Sapkal, Gajanan, Patil, Deepak Y., Dey, Ayan, Chandra, Harish, Deshpande, Gururaj, Gupta, Nivedita, Abraham, Priya, Kaushal, Himanshu, Sahay, Rima R., Tripathy, Anuradha, Nyayanit, Dimpal, Jain, Rajlaxmi, Kumar, Abhimanyu, Sarkale, Prasad, Baradkar, Shreekant, Rajanathan, Chozhavel, Raju, Hari Prasad, Patel, Satish, Shah, Niraj, Dwivedi, Pankaj, Singh, Dharmendra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Neutralizing Antibodies, Viral Bronchus COVID-19 DNA vaccine DNA vaccines Effectiveness Health risks Immune clearance Immune response Immune system Immunization Immunogenicity Immunogenicity, Vaccine Immunoglobulin G Infections Injection Lavage Lymphocytes Macaca mulatta needle‐free injection system nonhuman primates Pain SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Vaccines Vaccines, DNA Viral diseases Viral Vaccines Virology
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