Hematologic analysis of hospitalized patients and outpatients infected with SARS-CoV-2 and possible use as a prognostic biomarker
•Outpatients do not experience changes in erythroid series.•Hematic biometry can be used as a biomarker of the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).•Increases in neutrophil and decreases in lymphocyte counts suggest a prognosis of the severity of the disease. Seve...
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Veröffentlicht in: | Experimental hematology 2023-03, Vol.119-120, p.21-27 |
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creator | Girón-Pérez, Daniel Alberto Nava-Piedra, Ulises Netzahualcoyotl Esquivel-Esparza, Zulema Estefania Benitez-Trinidad, Alma Betsaida Barcelos-Garcia, Rocio Guadalupe Vázquez-Pulido, Erica Yolanda Toledo-Ibarra, Gladys Alejandra Ventura-Ramón, Guadalupe Herminia Covantes-Rosales, Carlos Eduardo Barajas-Carrillo, Victor Wagner Ojeda-Durán, Ansonny Jhovanny Díaz-Resendiz, Karina Janice Guadalupe Mercado-Salgado, Ulises Girón-Pérez, Manuel Iván |
description | •Outpatients do not experience changes in erythroid series.•Hematic biometry can be used as a biomarker of the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).•Increases in neutrophil and decreases in lymphocyte counts suggest a prognosis of the severity of the disease.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health problem; this has caused thousands of deaths around the world. This infection induces hematologic alterations, and it is necessary to recognize predictive biomarkers to address the need for hospitalization or the severity of the disease. This study aimed to analyze different parameters in outpatients and hospitalized patients infected with SARS-CoV-2 and determine whether hematic biometry can be used for prognosis rapidly. We analyzed 689 patients, of whom 355 were outpatients (162 women and 193 men) and 334 required hospitalization (197 men and 137 women). The average age of the hospitalized patients was 46 years (men, 49 years; women, 52 years), whereas the average age of the outpatients was 49 years (men, 51 years; women, 44 years). Hematologic parameters were analyzed and compared between the outpatients and hospitalized patients. The patients were divided into groups by age and sex. We found that in the hospitalized patients, the erythrocyte, hematocrit, and hemoglobin levels decreased, whereas the outpatients did not experience changes in the erythroid series. In leukocytes, these increased significantly, as they did in neutrophils; however, lymphocytopenia was observed. In the outpatients, we observed normal levels of neutrophils and lymphopenia. We can conclude that hematic biometry can be used as a biomarker, and the relation between neutrophils and lymphocytes is indicated for understanding the development and prognosis of the disease. |
doi_str_mv | 10.1016/j.exphem.2022.12.006 |
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health problem; this has caused thousands of deaths around the world. This infection induces hematologic alterations, and it is necessary to recognize predictive biomarkers to address the need for hospitalization or the severity of the disease. This study aimed to analyze different parameters in outpatients and hospitalized patients infected with SARS-CoV-2 and determine whether hematic biometry can be used for prognosis rapidly. We analyzed 689 patients, of whom 355 were outpatients (162 women and 193 men) and 334 required hospitalization (197 men and 137 women). The average age of the hospitalized patients was 46 years (men, 49 years; women, 52 years), whereas the average age of the outpatients was 49 years (men, 51 years; women, 44 years). Hematologic parameters were analyzed and compared between the outpatients and hospitalized patients. The patients were divided into groups by age and sex. We found that in the hospitalized patients, the erythrocyte, hematocrit, and hemoglobin levels decreased, whereas the outpatients did not experience changes in the erythroid series. In leukocytes, these increased significantly, as they did in neutrophils; however, lymphocytopenia was observed. In the outpatients, we observed normal levels of neutrophils and lymphopenia. We can conclude that hematic biometry can be used as a biomarker, and the relation between neutrophils and lymphocytes is indicated for understanding the development and prognosis of the disease.</description><identifier>ISSN: 0301-472X</identifier><identifier>EISSN: 1873-2399</identifier><identifier>DOI: 10.1016/j.exphem.2022.12.006</identifier><identifier>PMID: 36623718</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>COVID-19 ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Outpatients ; Prognosis ; SARS-CoV-2</subject><ispartof>Experimental hematology, 2023-03, Vol.119-120, p.21-27</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c357t-f339f8a03c91a3a4ff8e9e40fcaa6d94ed768504775093df6968eb32bf95917f3</cites><orcidid>0000-0002-9602-9881 ; 0000-0003-0101-1126 ; 0000-0003-0990-2871 ; 0000-0001-5396-5357 ; 0000-0001-6785-6688 ; 0000-0001-7349-7570</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36623718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Girón-Pérez, Daniel Alberto</creatorcontrib><creatorcontrib>Nava-Piedra, Ulises Netzahualcoyotl</creatorcontrib><creatorcontrib>Esquivel-Esparza, Zulema Estefania</creatorcontrib><creatorcontrib>Benitez-Trinidad, Alma Betsaida</creatorcontrib><creatorcontrib>Barcelos-Garcia, Rocio Guadalupe</creatorcontrib><creatorcontrib>Vázquez-Pulido, Erica Yolanda</creatorcontrib><creatorcontrib>Toledo-Ibarra, Gladys Alejandra</creatorcontrib><creatorcontrib>Ventura-Ramón, Guadalupe Herminia</creatorcontrib><creatorcontrib>Covantes-Rosales, Carlos Eduardo</creatorcontrib><creatorcontrib>Barajas-Carrillo, Victor Wagner</creatorcontrib><creatorcontrib>Ojeda-Durán, Ansonny Jhovanny</creatorcontrib><creatorcontrib>Díaz-Resendiz, Karina Janice Guadalupe</creatorcontrib><creatorcontrib>Mercado-Salgado, Ulises</creatorcontrib><creatorcontrib>Girón-Pérez, Manuel Iván</creatorcontrib><title>Hematologic analysis of hospitalized patients and outpatients infected with SARS-CoV-2 and possible use as a prognostic biomarker</title><title>Experimental hematology</title><addtitle>Exp Hematol</addtitle><description>•Outpatients do not experience changes in erythroid series.•Hematic biometry can be used as a biomarker of the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).•Increases in neutrophil and decreases in lymphocyte counts suggest a prognosis of the severity of the disease.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health problem; this has caused thousands of deaths around the world. This infection induces hematologic alterations, and it is necessary to recognize predictive biomarkers to address the need for hospitalization or the severity of the disease. This study aimed to analyze different parameters in outpatients and hospitalized patients infected with SARS-CoV-2 and determine whether hematic biometry can be used for prognosis rapidly. We analyzed 689 patients, of whom 355 were outpatients (162 women and 193 men) and 334 required hospitalization (197 men and 137 women). The average age of the hospitalized patients was 46 years (men, 49 years; women, 52 years), whereas the average age of the outpatients was 49 years (men, 51 years; women, 44 years). Hematologic parameters were analyzed and compared between the outpatients and hospitalized patients. The patients were divided into groups by age and sex. We found that in the hospitalized patients, the erythrocyte, hematocrit, and hemoglobin levels decreased, whereas the outpatients did not experience changes in the erythroid series. In leukocytes, these increased significantly, as they did in neutrophils; however, lymphocytopenia was observed. In the outpatients, we observed normal levels of neutrophils and lymphopenia. We can conclude that hematic biometry can be used as a biomarker, and the relation between neutrophils and lymphocytes is indicated for understanding the development and prognosis of the disease.</description><subject>COVID-19</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Outpatients</subject><subject>Prognosis</subject><subject>SARS-CoV-2</subject><issn>0301-472X</issn><issn>1873-2399</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1O3DAURi1UVAbaN0CVl90k9U9ixxskNKIFCalSgao7y3GuGU-TOMROge5485oOZdmVZel897v3IHRMSUkJFZ-2JTxMGxhKRhgrKSsJEXtoRRvJC8aVeoNWhBNaVJL9OECHMW4JIXWtyFt0wIVgXNJmhZ7OYTAp9OHWW2xG0z9GH3FweBPi5JPp_W_o8GSShzHFTHQ4LOn170cHNmXi3qcNvjr9dlWsw_eC_QWnEKNve8BLBGxyGE9zuB1DTLmr9WEw80-Y36F9Z_oI71_eI3Tz-ex6fV5cfv1ysT69LCyvZSoc58o1hnCrqOGmcq4BBRVx1hjRqQo6KZqaVFLWRPHOCSUaaDlrnaoVlY4foY-7uXmJuwVi0oOPFvrejBCWqJkUnPOKVk1Gqx1q53zCDE5Ps8_bPmpK9LN8vdU7-fpZvqZMZ_k59uGlYWkH6F5D_2xn4GQHQL7zl4dZR5s9Wuj8nDXqLvj_N_wBsOyZvg</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Girón-Pérez, Daniel Alberto</creator><creator>Nava-Piedra, Ulises Netzahualcoyotl</creator><creator>Esquivel-Esparza, Zulema Estefania</creator><creator>Benitez-Trinidad, Alma Betsaida</creator><creator>Barcelos-Garcia, Rocio Guadalupe</creator><creator>Vázquez-Pulido, Erica Yolanda</creator><creator>Toledo-Ibarra, Gladys Alejandra</creator><creator>Ventura-Ramón, Guadalupe Herminia</creator><creator>Covantes-Rosales, Carlos Eduardo</creator><creator>Barajas-Carrillo, Victor Wagner</creator><creator>Ojeda-Durán, Ansonny Jhovanny</creator><creator>Díaz-Resendiz, Karina Janice Guadalupe</creator><creator>Mercado-Salgado, Ulises</creator><creator>Girón-Pérez, Manuel Iván</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9602-9881</orcidid><orcidid>https://orcid.org/0000-0003-0101-1126</orcidid><orcidid>https://orcid.org/0000-0003-0990-2871</orcidid><orcidid>https://orcid.org/0000-0001-5396-5357</orcidid><orcidid>https://orcid.org/0000-0001-6785-6688</orcidid><orcidid>https://orcid.org/0000-0001-7349-7570</orcidid></search><sort><creationdate>202303</creationdate><title>Hematologic analysis of hospitalized patients and outpatients infected with SARS-CoV-2 and possible use as a prognostic biomarker</title><author>Girón-Pérez, Daniel Alberto ; 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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health problem; this has caused thousands of deaths around the world. This infection induces hematologic alterations, and it is necessary to recognize predictive biomarkers to address the need for hospitalization or the severity of the disease. This study aimed to analyze different parameters in outpatients and hospitalized patients infected with SARS-CoV-2 and determine whether hematic biometry can be used for prognosis rapidly. We analyzed 689 patients, of whom 355 were outpatients (162 women and 193 men) and 334 required hospitalization (197 men and 137 women). The average age of the hospitalized patients was 46 years (men, 49 years; women, 52 years), whereas the average age of the outpatients was 49 years (men, 51 years; women, 44 years). Hematologic parameters were analyzed and compared between the outpatients and hospitalized patients. The patients were divided into groups by age and sex. We found that in the hospitalized patients, the erythrocyte, hematocrit, and hemoglobin levels decreased, whereas the outpatients did not experience changes in the erythroid series. In leukocytes, these increased significantly, as they did in neutrophils; however, lymphocytopenia was observed. In the outpatients, we observed normal levels of neutrophils and lymphopenia. We can conclude that hematic biometry can be used as a biomarker, and the relation between neutrophils and lymphocytes is indicated for understanding the development and prognosis of the disease.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>36623718</pmid><doi>10.1016/j.exphem.2022.12.006</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9602-9881</orcidid><orcidid>https://orcid.org/0000-0003-0101-1126</orcidid><orcidid>https://orcid.org/0000-0003-0990-2871</orcidid><orcidid>https://orcid.org/0000-0001-5396-5357</orcidid><orcidid>https://orcid.org/0000-0001-6785-6688</orcidid><orcidid>https://orcid.org/0000-0001-7349-7570</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | COVID-19 Female Hospitalization Humans Male Middle Aged Outpatients Prognosis SARS-CoV-2 |
title | Hematologic analysis of hospitalized patients and outpatients infected with SARS-CoV-2 and possible use as a prognostic biomarker |
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