Easy access to α-carbonyl sulfones using cross-coupling of α-aryl-α-diazoesters with sulfonyl hydrazides

A facile synthesis of α-carbonyl sulfones has been accomplished by the cross-coupling of α-aryl-α-diazoesters with sulfonyl hydrazides in the presence of CuI and DBU. The reaction employs inexpensive and bench stable sulfonyl hydrazides as a sulfonyl source, and facilitates the migratory insertion w...

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Veröffentlicht in:	Organic & biomolecular chemistry 2023-02, Vol.21 (5), p.987-993
Hauptverfasser:	Sharma, Anup Kumar, Chand, Shiv, Kumar Pandey, Anand, Singh, Krishna Nand
Format:	Artikel
Sprache:	eng
Schlagworte:	Aromatic compounds Carbonyl compounds Carbonyls Cross coupling Hydrazides Sulfones
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description	A facile synthesis of α-carbonyl sulfones has been accomplished by the cross-coupling of α-aryl-α-diazoesters with sulfonyl hydrazides in the presence of CuI and DBU. The reaction employs inexpensive and bench stable sulfonyl hydrazides as a sulfonyl source, and facilitates the migratory insertion with α-aryl-α-diazoesters under mild reaction conditions. Cu-catalyzed cross-coupling of α-aryl-α-diazoesters with sulfonyl hydrazides is explored to access α-carbonyl sulfones via migratory insertion of Cu-carbene species.
doi_str_mv	10.1039/d2ob02219b
format	Article
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source	Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects	Aromatic compounds Carbonyl compounds Carbonyls Cross coupling Hydrazides Sulfones
title	Easy access to α-carbonyl sulfones using cross-coupling of α-aryl-α-diazoesters with sulfonyl hydrazides
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