MicroRNA-452: a double-edged sword in multiple human cancers
MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in various pathological processes including tumorigenesis and cancer progression through various mechanisms includin...
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| Veröffentlicht in: | Clinical & translational oncology 2023-05, Vol.25 (5), p.1189-1206 |
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| container_title | Clinical & translational oncology |
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| creator | Karimi Dermani, Fateme Datta, Ishwaree Gholamzadeh Khoei, Saeideh |
| description | MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in various pathological processes including tumorigenesis and cancer progression through various mechanisms including amplification or deletion of miRNA genes, mutations, and epigenetic silencing and defects in the miRNA biogenesis machinery. Several studies have now shown abnormal miRNA profiles and proved their involvement in the initiation and progression of cancer. Since miR-452 has diverse roles (as suppressor or oncogene) in different cellular processes including epithelial–mesenchymal transition (EMT), proliferation, migration, and invasion, in this review we highlight a brief overview of the biological function and regulatory mechanism of miR-452 and its involvement as a potential biomarker for diagnosis and treatment of various cancer types. |
| doi_str_mv | 10.1007/s12094-022-03041-0 |
| format | Article |
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MiRNA expression is deregulated in various pathological processes including tumorigenesis and cancer progression through various mechanisms including amplification or deletion of miRNA genes, mutations, and epigenetic silencing and defects in the miRNA biogenesis machinery. Several studies have now shown abnormal miRNA profiles and proved their involvement in the initiation and progression of cancer. Since miR-452 has diverse roles (as suppressor or oncogene) in different cellular processes including epithelial–mesenchymal transition (EMT), proliferation, migration, and invasion, in this review we highlight a brief overview of the biological function and regulatory mechanism of miR-452 and its involvement as a potential biomarker for diagnosis and treatment of various cancer types.</description><identifier>ISSN: 1699-3055</identifier><identifier>EISSN: 1699-3055</identifier><identifier>DOI: 10.1007/s12094-022-03041-0</identifier><identifier>PMID: 36622551</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Carcinogenesis - genetics ; Cell Line, Tumor ; Cell Proliferation - genetics ; Cell Transformation, Neoplastic - genetics ; Epithelial-Mesenchymal Transition - genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Medicine ; Medicine & Public Health ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Neoplasms - genetics ; Neoplasms - pathology ; Oncogenes ; Oncology ; Review Article</subject><ispartof>Clinical & translational oncology, 2023-05, Vol.25 (5), p.1189-1206</ispartof><rights>The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO) 2023. 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| source | MEDLINE; SpringerNature Journals |
| subjects | Carcinogenesis - genetics Cell Line, Tumor Cell Proliferation - genetics Cell Transformation, Neoplastic - genetics Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation, Neoplastic Humans Medicine Medicine & Public Health MicroRNAs - genetics MicroRNAs - metabolism Neoplasms - genetics Neoplasms - pathology Oncogenes Oncology Review Article |
| title | MicroRNA-452: a double-edged sword in multiple human cancers |
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