Esterase-Responsive Polymeric Micelles Containing Tetraphenylethene and Poly(ethylene glycol) Moieties for Efficient Doxorubicin Delivery and Tumor Therapy

Enzyme-responsive drug delivery systems have drawn much attention in the field of cancer theranostics due to their high sensitivity and substrate specificity under mild conditions. In this study, an amphiphilic polymer T1 is reported, which contains a tetraphenylethene unit and a poly(ethylene glyc...

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Veröffentlicht in:	Bioconjugate chemistry 2023-01, Vol.34 (1), p.248-256
Hauptverfasser:	Xu, De-Zhong, Sun, Xue-Yi, Liang, Ya-Xuan, Huang, Hai-Wei, Liu, Rui, Lu, Zhong-Lin, He, Lan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aqueous solutions Cancer therapies Doxorubicin Doxorubicin - pharmacology Doxorubicin - therapeutic use Drug Carriers - chemistry Drug delivery Drug Delivery Systems Esterase Esterases HeLa Cells Humans Hydrogen-Ion Concentration Hydrophobicity Micelles Phenolic compounds Phenols Polyethylene glycol Polyethylene Glycols - chemistry Polymers Polymers - chemistry Precision medicine Self-assembly Side effects Substrate specificity Substrates Tumors
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