Incorporation of 53BP1 into phase-separated bodies in cancer cells during aberrant mitosis

53BP1 (also known as TP53BP1) is a key mediator of the non-homologous end joining (NHEJ) DNA repair pathway, which is the primary repair pathway in interphase cells. However, the mitotic functions of 53BP1 are less well understood. Here, we describe 53BP1 mitotic stress bodies (MSBs) formed in cance...

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Veröffentlicht in:	Journal of cell science 2023-01, Vol.136 (1)
Hauptverfasser:	Bleiler, Marina, Cyr, Aiyana, Wright, Dennis L, Giardina, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Chromatin DNA Damage DNA End-Joining Repair DNA Repair Humans Mitosis Neoplasms - genetics Tumor Suppressor p53-Binding Protein 1 - genetics Tumor Suppressor p53-Binding Protein 1 - metabolism
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