MiR-3612 targeting THBS1 suppresses nasopharyngeal carcinoma progression by PI3K/AKT signaling pathway

Background MicroRNA-3612 (miR-3612) is considered a tumor suppressor in different cancers. Nonetheless, its function in nasopharyngeal carcinoma (NPC) has yet to be uncovered. Methods NPC cells and tissues were tested by means of reverse transcription quantitative polymerase chain reaction (RT-qPCR)...

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Veröffentlicht in:	Human & experimental toxicology 2023-01, Vol.42, p.9603271221150248-9603271221150248
Hauptverfasser:	Zhang, Wei, Zhang, Qiu, Cui, Qianbo, Xu, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adhesion AKT protein Cancer Cell activation Cell adhesion Cell Line, Tumor Cell migration Cell Movement Cell Proliferation Cholecystokinin Deactivation Down-regulation Gene Expression Regulation, Neoplastic Humans Kinases MicroRNAs - genetics MicroRNAs - metabolism miRNA Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - pathology Nasopharyngeal Neoplasms - pathology Phosphatidylinositol 3-Kinase - metabolism Phosphatidylinositol 3-Kinases - metabolism Polymerase chain reaction Proto-Oncogene Proteins c-akt - metabolism Reverse transcription Signal Transduction Throat cancer Thrombospondin Thrombospondin 1 - genetics Thrombospondin 1 - metabolism Tumor suppressor genes Tumorigenesis Tumorigenicity Western blotting
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