The inflammatory score and cardiovascular risk in young adults with overweight or obesity: The African-PREDICT study
[Display omitted] •Seemingly healthy young adults with excess adiposity may have higher health risks.•The inflammatory score is a comprehensive marker of adiposity-related inflammation.•A higher inflammatory score may be an indication of early cardiovascular risk.•The inflammatory score can be used...
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| Veröffentlicht in: | Cytokine (Philadelphia, Pa.) Pa.), 2023-03, Vol.163, p.156121-156121, Article 156121 |
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| creator | van Niekerk, Elandi Mels, Catharina M.C. Swanepoel, Mariëtte Delles, Christian Welsh, Paul Botha-Le Roux, Shani |
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•Seemingly healthy young adults with excess adiposity may have higher health risks.•The inflammatory score is a comprehensive marker of adiposity-related inflammation.•A higher inflammatory score may be an indication of early cardiovascular risk.•The inflammatory score can be used in young adults with overweight and/or obesity.
A complex relationship of adipokines and cytokines with cardiovascular risk motivates the use of an integrated approach to identify early signs of adiposity-related inflammation. We compared the inflammatory profiles, including an integrated inflammatory score, and cardiovascular profiles of young adults who are living with overweight and/or obesity (OW/OB).
This cross-sectional study included 1194 men and women with a median age of 24.5 ± 3.12 years from the African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT). Participants were divided into approximate quartiles based on adiposity measures (body mass index, waist circumference, and waist-to-height ratio). We compared an integrated inflammatory score (including leptin, adiponectin, interleukin-6, interleukin-8, interleukin-10, and tumour necrosis factor-α) as well as the individual inflammatory markers, between extreme quartiles. We also compared blood pressure measures, left ventricular mass index, carotid-femoral pulse wave velocity, and carotid intima-media thickness between these groups.
Individuals in the top quartile had worse inflammatory- and cardiovascular profiles as the integrated inflammatory score, leptin, interleukin-6, blood pressure measures, and left ventricular mass index were higher, while adiponectin was lower (all p ≤ 0.003). Unexpectedly, carotid-femoral pulse wave velocity was also lower (p |
| doi_str_mv | 10.1016/j.cyto.2022.156121 |
| format | Article |
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•Seemingly healthy young adults with excess adiposity may have higher health risks.•The inflammatory score is a comprehensive marker of adiposity-related inflammation.•A higher inflammatory score may be an indication of early cardiovascular risk.•The inflammatory score can be used in young adults with overweight and/or obesity.
A complex relationship of adipokines and cytokines with cardiovascular risk motivates the use of an integrated approach to identify early signs of adiposity-related inflammation. We compared the inflammatory profiles, including an integrated inflammatory score, and cardiovascular profiles of young adults who are living with overweight and/or obesity (OW/OB).
This cross-sectional study included 1194 men and women with a median age of 24.5 ± 3.12 years from the African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT). Participants were divided into approximate quartiles based on adiposity measures (body mass index, waist circumference, and waist-to-height ratio). We compared an integrated inflammatory score (including leptin, adiponectin, interleukin-6, interleukin-8, interleukin-10, and tumour necrosis factor-α) as well as the individual inflammatory markers, between extreme quartiles. We also compared blood pressure measures, left ventricular mass index, carotid-femoral pulse wave velocity, and carotid intima-media thickness between these groups.
Individuals in the top quartile had worse inflammatory- and cardiovascular profiles as the integrated inflammatory score, leptin, interleukin-6, blood pressure measures, and left ventricular mass index were higher, while adiponectin was lower (all p ≤ 0.003). Unexpectedly, carotid-femoral pulse wave velocity was also lower (p < 0.001) in the top quartile. Exclusively in the top quartile, all adiposity measures related positively with the integrated inflammatory score and central systolic blood pressure (both r ≥ 0.24; p < 0.001), and negatively with interleukin-10 (all r ≤ -0.13; p < 0.03). Of these relationships, the correlations with the integrated inflammatory score were the strongest (p < 0.001). The percentage difference of being in the top quartile of all adiposity measures were higher for the inflammatory score (all ≥ 263 %), leptin (all ≥ 175 %), interleukin-6 (all ≥ 134 %), and tumour necrosis factor-α (all ≥ 26 %), and lower for adiponectin (all ≥ 57 %), interleukin-10 (all ≥ 9 %), and interleukin-8 (all ≥ 15 %) compared to being in the bottom quartile.
The inflammatory score, as a comprehensive marker of adiposity-related inflammation, is strongly related to adiposity and may be an indication of early cardiovascular risk in young adults; however, further work is required to establish the clinical use thereof.</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/j.cyto.2022.156121</identifier><identifier>PMID: 36610286</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adiponectin ; Adiposity ; Adiposity-related inflammation ; Adult ; Blood pressure ; Cardiovascular Diseases ; Carotid Intima-Media Thickness ; Carotid-femoral pulse wave velocity ; Cross-Sectional Studies ; Female ; Heart Disease Risk Factors ; Humans ; Inflammation ; Interleukin-10 ; Interleukin-6 ; Interleukin-8 ; Left ventricular remodeling ; Leptin ; Male ; Obesity ; Overweight ; Prospective Studies ; Pulse Wave Analysis ; Risk Factors ; Tumor Necrosis Factor-alpha ; Young Adult ; Young adults</subject><ispartof>Cytokine (Philadelphia, Pa.), 2023-03, Vol.163, p.156121-156121, Article 156121</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-90290b7c07091e7811c2abf8fb08d565dabb7ae697c70418c9c6375e53874623</citedby><cites>FETCH-LOGICAL-c356t-90290b7c07091e7811c2abf8fb08d565dabb7ae697c70418c9c6375e53874623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cyto.2022.156121$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36610286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Niekerk, Elandi</creatorcontrib><creatorcontrib>Mels, Catharina M.C.</creatorcontrib><creatorcontrib>Swanepoel, Mariëtte</creatorcontrib><creatorcontrib>Delles, Christian</creatorcontrib><creatorcontrib>Welsh, Paul</creatorcontrib><creatorcontrib>Botha-Le Roux, Shani</creatorcontrib><title>The inflammatory score and cardiovascular risk in young adults with overweight or obesity: The African-PREDICT study</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description>[Display omitted]
•Seemingly healthy young adults with excess adiposity may have higher health risks.•The inflammatory score is a comprehensive marker of adiposity-related inflammation.•A higher inflammatory score may be an indication of early cardiovascular risk.•The inflammatory score can be used in young adults with overweight and/or obesity.
A complex relationship of adipokines and cytokines with cardiovascular risk motivates the use of an integrated approach to identify early signs of adiposity-related inflammation. We compared the inflammatory profiles, including an integrated inflammatory score, and cardiovascular profiles of young adults who are living with overweight and/or obesity (OW/OB).
This cross-sectional study included 1194 men and women with a median age of 24.5 ± 3.12 years from the African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT). Participants were divided into approximate quartiles based on adiposity measures (body mass index, waist circumference, and waist-to-height ratio). We compared an integrated inflammatory score (including leptin, adiponectin, interleukin-6, interleukin-8, interleukin-10, and tumour necrosis factor-α) as well as the individual inflammatory markers, between extreme quartiles. We also compared blood pressure measures, left ventricular mass index, carotid-femoral pulse wave velocity, and carotid intima-media thickness between these groups.
Individuals in the top quartile had worse inflammatory- and cardiovascular profiles as the integrated inflammatory score, leptin, interleukin-6, blood pressure measures, and left ventricular mass index were higher, while adiponectin was lower (all p ≤ 0.003). Unexpectedly, carotid-femoral pulse wave velocity was also lower (p < 0.001) in the top quartile. Exclusively in the top quartile, all adiposity measures related positively with the integrated inflammatory score and central systolic blood pressure (both r ≥ 0.24; p < 0.001), and negatively with interleukin-10 (all r ≤ -0.13; p < 0.03). Of these relationships, the correlations with the integrated inflammatory score were the strongest (p < 0.001). The percentage difference of being in the top quartile of all adiposity measures were higher for the inflammatory score (all ≥ 263 %), leptin (all ≥ 175 %), interleukin-6 (all ≥ 134 %), and tumour necrosis factor-α (all ≥ 26 %), and lower for adiponectin (all ≥ 57 %), interleukin-10 (all ≥ 9 %), and interleukin-8 (all ≥ 15 %) compared to being in the bottom quartile.
The inflammatory score, as a comprehensive marker of adiposity-related inflammation, is strongly related to adiposity and may be an indication of early cardiovascular risk in young adults; however, further work is required to establish the clinical use thereof.</description><subject>Adiponectin</subject><subject>Adiposity</subject><subject>Adiposity-related inflammation</subject><subject>Adult</subject><subject>Blood pressure</subject><subject>Cardiovascular Diseases</subject><subject>Carotid Intima-Media Thickness</subject><subject>Carotid-femoral pulse wave velocity</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Heart Disease Risk Factors</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin-10</subject><subject>Interleukin-6</subject><subject>Interleukin-8</subject><subject>Left ventricular remodeling</subject><subject>Leptin</subject><subject>Male</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Prospective Studies</subject><subject>Pulse Wave Analysis</subject><subject>Risk Factors</subject><subject>Tumor Necrosis Factor-alpha</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQQC1ExVf7B3pAPnLJduwkdoK4oC20SEitqr1bjj1hvU1isJ1F-fdNtMCxp5nDmyfNI-QrgxUDJr7tVmZKfsWB8xUrBePsiJwxqEUGwPPjZS_yrBBCnJLzGHcAUOdSnpDTXAgGvBJnJG22SN3QdrrvdfJhotH4gFQPlhodrPN7Hc3Y6UCDi39nlE5-HJ6otmOXIn11aUv9HsMruqdtoj5Q32B0abqmi_q2Dc7oIfv95-77w3pDYxrt9Jl8anUX8cvbvCCb-7vN-mf2-OvHw_r2MTN5KVJWA6-hkQYk1AxlxZjhummrtoHKlqK0ummkRlFLI6FglamNyGWJZV7JQvD8glwdtM_Bv4wYk-pdNNh1ekA_RsWlYHVVlEU5o_yAmuBjDNiq5-B6HSbFQC2x1U4tsdUSWx1iz0eXb_6x6dF-nLzXnYGbA4Dzk3uHQUXjcDBoXUCTlPXuf_5_EjSQww</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>van Niekerk, Elandi</creator><creator>Mels, Catharina M.C.</creator><creator>Swanepoel, Mariëtte</creator><creator>Delles, Christian</creator><creator>Welsh, Paul</creator><creator>Botha-Le Roux, Shani</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202303</creationdate><title>The inflammatory score and cardiovascular risk in young adults with overweight or obesity: The African-PREDICT study</title><author>van Niekerk, Elandi ; Mels, Catharina M.C. ; Swanepoel, Mariëtte ; Delles, Christian ; Welsh, Paul ; Botha-Le Roux, Shani</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-90290b7c07091e7811c2abf8fb08d565dabb7ae697c70418c9c6375e53874623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adiponectin</topic><topic>Adiposity</topic><topic>Adiposity-related inflammation</topic><topic>Adult</topic><topic>Blood pressure</topic><topic>Cardiovascular Diseases</topic><topic>Carotid Intima-Media Thickness</topic><topic>Carotid-femoral pulse wave velocity</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Heart Disease Risk Factors</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin-10</topic><topic>Interleukin-6</topic><topic>Interleukin-8</topic><topic>Left ventricular remodeling</topic><topic>Leptin</topic><topic>Male</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Prospective Studies</topic><topic>Pulse Wave Analysis</topic><topic>Risk Factors</topic><topic>Tumor Necrosis Factor-alpha</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Niekerk, Elandi</creatorcontrib><creatorcontrib>Mels, Catharina M.C.</creatorcontrib><creatorcontrib>Swanepoel, Mariëtte</creatorcontrib><creatorcontrib>Delles, Christian</creatorcontrib><creatorcontrib>Welsh, Paul</creatorcontrib><creatorcontrib>Botha-Le Roux, Shani</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cytokine (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Niekerk, Elandi</au><au>Mels, Catharina M.C.</au><au>Swanepoel, Mariëtte</au><au>Delles, Christian</au><au>Welsh, Paul</au><au>Botha-Le Roux, Shani</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The inflammatory score and cardiovascular risk in young adults with overweight or obesity: The African-PREDICT study</atitle><jtitle>Cytokine (Philadelphia, Pa.)</jtitle><addtitle>Cytokine</addtitle><date>2023-03</date><risdate>2023</risdate><volume>163</volume><spage>156121</spage><epage>156121</epage><pages>156121-156121</pages><artnum>156121</artnum><issn>1043-4666</issn><eissn>1096-0023</eissn><abstract>[Display omitted]
•Seemingly healthy young adults with excess adiposity may have higher health risks.•The inflammatory score is a comprehensive marker of adiposity-related inflammation.•A higher inflammatory score may be an indication of early cardiovascular risk.•The inflammatory score can be used in young adults with overweight and/or obesity.
A complex relationship of adipokines and cytokines with cardiovascular risk motivates the use of an integrated approach to identify early signs of adiposity-related inflammation. We compared the inflammatory profiles, including an integrated inflammatory score, and cardiovascular profiles of young adults who are living with overweight and/or obesity (OW/OB).
This cross-sectional study included 1194 men and women with a median age of 24.5 ± 3.12 years from the African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT). Participants were divided into approximate quartiles based on adiposity measures (body mass index, waist circumference, and waist-to-height ratio). We compared an integrated inflammatory score (including leptin, adiponectin, interleukin-6, interleukin-8, interleukin-10, and tumour necrosis factor-α) as well as the individual inflammatory markers, between extreme quartiles. We also compared blood pressure measures, left ventricular mass index, carotid-femoral pulse wave velocity, and carotid intima-media thickness between these groups.
Individuals in the top quartile had worse inflammatory- and cardiovascular profiles as the integrated inflammatory score, leptin, interleukin-6, blood pressure measures, and left ventricular mass index were higher, while adiponectin was lower (all p ≤ 0.003). Unexpectedly, carotid-femoral pulse wave velocity was also lower (p < 0.001) in the top quartile. Exclusively in the top quartile, all adiposity measures related positively with the integrated inflammatory score and central systolic blood pressure (both r ≥ 0.24; p < 0.001), and negatively with interleukin-10 (all r ≤ -0.13; p < 0.03). Of these relationships, the correlations with the integrated inflammatory score were the strongest (p < 0.001). The percentage difference of being in the top quartile of all adiposity measures were higher for the inflammatory score (all ≥ 263 %), leptin (all ≥ 175 %), interleukin-6 (all ≥ 134 %), and tumour necrosis factor-α (all ≥ 26 %), and lower for adiponectin (all ≥ 57 %), interleukin-10 (all ≥ 9 %), and interleukin-8 (all ≥ 15 %) compared to being in the bottom quartile.
The inflammatory score, as a comprehensive marker of adiposity-related inflammation, is strongly related to adiposity and may be an indication of early cardiovascular risk in young adults; however, further work is required to establish the clinical use thereof.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36610286</pmid><doi>10.1016/j.cyto.2022.156121</doi><tpages>1</tpages></addata></record> |
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| subjects | Adiponectin Adiposity Adiposity-related inflammation Adult Blood pressure Cardiovascular Diseases Carotid Intima-Media Thickness Carotid-femoral pulse wave velocity Cross-Sectional Studies Female Heart Disease Risk Factors Humans Inflammation Interleukin-10 Interleukin-6 Interleukin-8 Left ventricular remodeling Leptin Male Obesity Overweight Prospective Studies Pulse Wave Analysis Risk Factors Tumor Necrosis Factor-alpha Young Adult Young adults |
| title | The inflammatory score and cardiovascular risk in young adults with overweight or obesity: The African-PREDICT study |
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