Effect and mechanism of pirfenidone combined with 2-methoxy-estradiol perfusion through portal vein on hepatic artery hypoxia-induced hepatic fibrosis

The aim of this study was to explore the effect and mechanism of pirfenidone (PFD) combined with 2-methoxyestradiol (2-ME2) perfusion through portal vein on hepatic artery hypoxia-induced hepatic fibrosis. Sprague-Dawley rats were divided into 5 groups (n = 3/group): control group, hepatic artery...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Advances in medical sciences 2023-03, Vol.68 (1), p.46-53
Hauptverfasser:	Zheng, Hui, Huang, Ning, Lin, Jun-qing, Yan, Le-ye, Jiang, Qing-gui, Yang, Wei-zhu
Format:	Artikel
Sprache:	eng
Schlagworte:	2-methoxyestradiol 2-Methoxyestradiol - pharmacology 2-Methoxyestradiol - therapeutic use Animals Collagen Fibrosis Hepatic Artery - metabolism Hepatic fibrosis Hypoxia Liver Cirrhosis - drug therapy Matrix Metalloproteinase 2 Perfusion Pirfenidone Portal Vein - metabolism Portal vein perfusion Rats Rats, Sprague-Dawley Tissue Inhibitor of Metalloproteinase-1 - genetics Transforming Growth Factor beta1 - adverse effects Transforming Growth Factor beta1 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!