Development of a Bispecific Antibody Targeting Clinical Isolates of Acinetobacter baumannii

Abstract Background We previously reported developing 2 anticapsular monoclonal antibodies (mAbs) as a novel therapy for Acinetobacter baumannii infections. We sought to determine whether a bispecific mAb (bsAb) could improve avidity and efficacy while maximizing strain coverage in one molecule. Met...

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Veröffentlicht in:	The Journal of infectious diseases 2023-04, Vol.227 (9), p.1042-1049
Hauptverfasser:	Nielsen, Travis B, Yan, Jun, Slarve, Matthew, Li, Rachel, Junge, Jason A, Luna, Brian M, Wilkinson, Ian, Yerramalla, Udaya, Spellberg, Brad
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter baumannii Affinity Antibiotics Antibodies Antibodies, Bispecific - chemistry Antibodies, Monoclonal - therapeutic use Avidity Bacterial infections Bispecific antibodies Clinical isolates Immunotherapy Monoclonal antibodies Opsonization Single-Chain Antibodies
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