Overexpression of a predicted transketolase gene and disruption of an α-1,3-glucan synthase gene in Aspergillus oryzae DGLA3 strain enhances the yield of free dihomo-γ-linolenic acid

ABSTRACT Free dihomo-γ-linolenic acid (DGLA), a polyunsaturated free fatty acid (FFA), can potentially be used to produce eicosanoid pharmaceuticals, such as prostaglandin E1. Previously, we constructed an Aspergillus oryzae mutant strain, named DGLA3, which produced free DGLA at an increased yield...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2023-03, Vol.87 (4), p.448-457
Hauptverfasser:	Tamano, Koichi, Nakai, Shiori, Takayama, Haruka, Imai, Yasuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	8,11,14-Eicosatrienoic Acid - metabolism Aspergillus oryzae - genetics Aspergillus oryzae - metabolism Fatty Acids, Nonesterified - metabolism Glucans - metabolism Transketolase - genetics Transketolase - metabolism
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