Upregulation of CD86 and IL-12 by rhododendrol in THP-1 cells cocultured with melanocytes through ROS and ATP

The tyrosinase inhibitor rhododendrol (RD), used as a skin whitening agent, reportedly has the potential to induce leukoderma. Although an immune response toward melanocytes was demonstrated to be involved in leukoderma, the molecular mechanism is not fully understood. We hypothesized that if RD is...

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Veröffentlicht in:	Journal of dermatological science 2022-12, Vol.108 (3), p.167-177
Hauptverfasser:	Katahira, Yasuhiro, Sakamoto, Eri, Watanabe, Aruma, Furusaka, Yuma, Inoue, Shinya, Hasegawa, Hideaki, Mizoguchi, Izuru, Yo, Kazuyuki, Yamaji, Fumiya, Toyoda, Akemi, Yoshimoto, Takayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Coculture Techniques H-CLAT Humans Hypopigmentation - metabolism Interleukin-12 - metabolism Interleukin-12 - pharmacology Leukoderma Melanocytes Melanocytes - metabolism Melanoma - metabolism Monophenol Monooxygenase - metabolism Pro-hapten Reactive Oxygen Species - metabolism Rhododendrol Sensitizer Skin Lightening Preparations - pharmacology THP-1 Cells Up-Regulation
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