Tuberin levels during cellular differentiation in brain development

Tuberin is a member of a large protein complex, Tuberous Sclerosis Complex (TSC), and acts as a sensor for nutrient status regulating protein synthesis and cell cycle progression. Mutations in the Tuberin gene, TSC2, permits the formation of tumors that can lead to developmental defects in many orga...

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Veröffentlicht in:	Differentiation (London) 2023-03, Vol.130, p.43-50
Hauptverfasser:	Fidalgo da Silva, Elizabeth, Abu Khatir, Bashaer, Drouillard, Christopher, Hinch, Isabelle, Davis, Gordon Omar, Sameem, Mariam, Patel, Rutu, Fong, Jackie, Lubanska, Dorota, Porter, Lisa A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - metabolism Brain - pathology Cell Differentiation Differentiation Embryonic development Female Humans Neural Stem Cell Neurosphere Pregnancy Repressor Proteins - genetics Repressor Proteins - metabolism Stemness Tuberin Tuberous Sclerosis Complex Tuberous Sclerosis Complex 1 Protein - metabolism Tuberous Sclerosis Complex 2 Protein Tumor Suppressor Proteins - genetics
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