JUND facilitates proliferation and angiogenesis of esophageal squamous cell carcinoma cell via MAPRE2 up-regulation
Esophageal squamous cell carcinoma (ESCC) is a globally aggressive malignant tumor. This study aimed to investigate the mechanism of JUND in ESCC development via MAPRE2. ESCC cells (KYSE-450 and ECA109) were transfected with small interfering RNA (si)-JUND, si-MAPRE2, si-JUND, or pcDNA3.1-MAPRE2. JU...
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| Veröffentlicht in: | Tissue & cell 2023-04, Vol.81, p.102010-102010, Article 102010 |
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| creator | Zhang, Deming Pan, Gaofeng Cheng, Nitao Sun, Linao Zhou, Xuefeng Li, Changsheng Zhao, Jinping |
| description | Esophageal squamous cell carcinoma (ESCC) is a globally aggressive malignant tumor. This study aimed to investigate the mechanism of JUND in ESCC development via MAPRE2.
ESCC cells (KYSE-450 and ECA109) were transfected with small interfering RNA (si)-JUND, si-MAPRE2, si-JUND, or pcDNA3.1-MAPRE2. JUND and MAPRE2 expression in ESCC cells was detected with quantitative real-time polymerase chain reaction and western blot. Cell counting kit-8 and 5-ethynyl-2′-deoxyuridine assays were used to determine ESCC cell proliferation. Dual-luciferase reporter gene and chromatin immunoprecipitation assays were performed to assess binding between JUND and MAPRE2. Human umbilical vein endothelial cells (HUVECs) were co-cultured with ESCC cell supernatants. Angiogenesis was assessed with an in vitro angiogenesis assay. Western blot was conducted to evaluate the expression of angiogenic proteins [vascular endothelial growth factor A (VEGFA), matrix metallopeptidase 9 (MMP-9), and angiopoietin-2 (ang2)].
The levels of expression of JUND and MAPRE2 were high in ESCC cells. Mechanistically, JUND bound to MAPRE2 promoter and increased MAPRE2 transcription. Downregulation of JUND or MAPRE2 inhibited KYSE-450 and ECA109 cell proliferation and reduced the levels of expression of VEGFA, MMP-9, and ang2 and tube formation in HUVECs co-cultured with ESCC cell supernatants. MAPRE2 upregulation counteracted the inhibitory effects of JUND silencing on cell proliferative and angiogenic capabilities in ESCC.
JUND promoted MAPRE2 transcription, thereby facilitating cell proliferative and angiogenic abilities in ESCC.
•MAPRE2 and JUND are highly expressed in ESCC cell lines.•MAPRE2 down-regulation suppresses cell proliferation and angiogenesis in ESCC.•JUND facilitates the transcription of MAPRE2.•JUND down-regulation curbs cell proliferation and angiogenesis in ESCC.•JUND promoted cell proliferation and angiogenesis in ESCC via MAPRE2. |
| doi_str_mv | 10.1016/j.tice.2022.102010 |
| format | Article |
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ESCC cells (KYSE-450 and ECA109) were transfected with small interfering RNA (si)-JUND, si-MAPRE2, si-JUND, or pcDNA3.1-MAPRE2. JUND and MAPRE2 expression in ESCC cells was detected with quantitative real-time polymerase chain reaction and western blot. Cell counting kit-8 and 5-ethynyl-2′-deoxyuridine assays were used to determine ESCC cell proliferation. Dual-luciferase reporter gene and chromatin immunoprecipitation assays were performed to assess binding between JUND and MAPRE2. Human umbilical vein endothelial cells (HUVECs) were co-cultured with ESCC cell supernatants. Angiogenesis was assessed with an in vitro angiogenesis assay. Western blot was conducted to evaluate the expression of angiogenic proteins [vascular endothelial growth factor A (VEGFA), matrix metallopeptidase 9 (MMP-9), and angiopoietin-2 (ang2)].
The levels of expression of JUND and MAPRE2 were high in ESCC cells. Mechanistically, JUND bound to MAPRE2 promoter and increased MAPRE2 transcription. Downregulation of JUND or MAPRE2 inhibited KYSE-450 and ECA109 cell proliferation and reduced the levels of expression of VEGFA, MMP-9, and ang2 and tube formation in HUVECs co-cultured with ESCC cell supernatants. MAPRE2 upregulation counteracted the inhibitory effects of JUND silencing on cell proliferative and angiogenic capabilities in ESCC.
JUND promoted MAPRE2 transcription, thereby facilitating cell proliferative and angiogenic abilities in ESCC.
•MAPRE2 and JUND are highly expressed in ESCC cell lines.•MAPRE2 down-regulation suppresses cell proliferation and angiogenesis in ESCC.•JUND facilitates the transcription of MAPRE2.•JUND down-regulation curbs cell proliferation and angiogenesis in ESCC.•JUND promoted cell proliferation and angiogenesis in ESCC via MAPRE2.</description><identifier>ISSN: 0040-8166</identifier><identifier>EISSN: 1532-3072</identifier><identifier>DOI: 10.1016/j.tice.2022.102010</identifier><identifier>PMID: 36608637</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Angiogenesis ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation - genetics ; Endothelial Cells - metabolism ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - metabolism ; Esophageal Neoplasms - pathology ; Esophageal squamous cell carcinoma ; Esophageal Squamous Cell Carcinoma - genetics ; Esophageal Squamous Cell Carcinoma - metabolism ; Esophageal Squamous Cell Carcinoma - pathology ; Gene Expression Regulation, Neoplastic ; Humans ; JUND ; MAPRE2 ; Matrix Metalloproteinase 9 - genetics ; MicroRNAs - genetics ; Microtubule-Associated Proteins - genetics ; Microtubule-Associated Proteins - metabolism ; Neovascularization, Pathologic - genetics ; Neovascularization, Pathologic - metabolism ; Proliferation ; Proto-Oncogene Proteins c-jun - genetics ; Proto-Oncogene Proteins c-jun - metabolism ; RNA, Small Interfering ; Transcription factor ; Up-Regulation - genetics ; Vascular Endothelial Growth Factor A - genetics ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>Tissue & cell, 2023-04, Vol.81, p.102010-102010, Article 102010</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-e4df9dd7c47badd0ed94dad87e1a0a01401df26b2c6cb77db372305ad66c79893</citedby><cites>FETCH-LOGICAL-c356t-e4df9dd7c47badd0ed94dad87e1a0a01401df26b2c6cb77db372305ad66c79893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tice.2022.102010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36608637$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Deming</creatorcontrib><creatorcontrib>Pan, Gaofeng</creatorcontrib><creatorcontrib>Cheng, Nitao</creatorcontrib><creatorcontrib>Sun, Linao</creatorcontrib><creatorcontrib>Zhou, Xuefeng</creatorcontrib><creatorcontrib>Li, Changsheng</creatorcontrib><creatorcontrib>Zhao, Jinping</creatorcontrib><title>JUND facilitates proliferation and angiogenesis of esophageal squamous cell carcinoma cell via MAPRE2 up-regulation</title><title>Tissue & cell</title><addtitle>Tissue Cell</addtitle><description>Esophageal squamous cell carcinoma (ESCC) is a globally aggressive malignant tumor. This study aimed to investigate the mechanism of JUND in ESCC development via MAPRE2.
ESCC cells (KYSE-450 and ECA109) were transfected with small interfering RNA (si)-JUND, si-MAPRE2, si-JUND, or pcDNA3.1-MAPRE2. JUND and MAPRE2 expression in ESCC cells was detected with quantitative real-time polymerase chain reaction and western blot. Cell counting kit-8 and 5-ethynyl-2′-deoxyuridine assays were used to determine ESCC cell proliferation. Dual-luciferase reporter gene and chromatin immunoprecipitation assays were performed to assess binding between JUND and MAPRE2. Human umbilical vein endothelial cells (HUVECs) were co-cultured with ESCC cell supernatants. Angiogenesis was assessed with an in vitro angiogenesis assay. Western blot was conducted to evaluate the expression of angiogenic proteins [vascular endothelial growth factor A (VEGFA), matrix metallopeptidase 9 (MMP-9), and angiopoietin-2 (ang2)].
The levels of expression of JUND and MAPRE2 were high in ESCC cells. Mechanistically, JUND bound to MAPRE2 promoter and increased MAPRE2 transcription. Downregulation of JUND or MAPRE2 inhibited KYSE-450 and ECA109 cell proliferation and reduced the levels of expression of VEGFA, MMP-9, and ang2 and tube formation in HUVECs co-cultured with ESCC cell supernatants. MAPRE2 upregulation counteracted the inhibitory effects of JUND silencing on cell proliferative and angiogenic capabilities in ESCC.
JUND promoted MAPRE2 transcription, thereby facilitating cell proliferative and angiogenic abilities in ESCC.
•MAPRE2 and JUND are highly expressed in ESCC cell lines.•MAPRE2 down-regulation suppresses cell proliferation and angiogenesis in ESCC.•JUND facilitates the transcription of MAPRE2.•JUND down-regulation curbs cell proliferation and angiogenesis in ESCC.•JUND promoted cell proliferation and angiogenesis in ESCC via MAPRE2.</description><subject>Angiogenesis</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement</subject><subject>Cell Proliferation - genetics</subject><subject>Endothelial Cells - metabolism</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - metabolism</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal squamous cell carcinoma</subject><subject>Esophageal Squamous Cell Carcinoma - genetics</subject><subject>Esophageal Squamous Cell Carcinoma - metabolism</subject><subject>Esophageal Squamous Cell Carcinoma - pathology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>JUND</subject><subject>MAPRE2</subject><subject>Matrix Metalloproteinase 9 - genetics</subject><subject>MicroRNAs - genetics</subject><subject>Microtubule-Associated Proteins - genetics</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Neovascularization, Pathologic - genetics</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Proliferation</subject><subject>Proto-Oncogene Proteins c-jun - genetics</subject><subject>Proto-Oncogene Proteins c-jun - metabolism</subject><subject>RNA, Small Interfering</subject><subject>Transcription factor</subject><subject>Up-Regulation - genetics</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>0040-8166</issn><issn>1532-3072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P5DAMhiMEWmbZ_QMcUI5cOuuknWQqcUEw7If40grOkZu4Q0ZtMyQtEv-eDoU97sGybL1-9fph7FjAXIBQPzbz3luaS5ByXEgQsMdmYpHLLAct99kMoIBsKZQ6ZF9T2gCALoT-wg5zpWCpcj1j6c_j7SWv0frG99hT4tsYGl9TxN6HjmPnxlr7sKaOkk881JxS2D7hmrDh6XnANgyJW2oabjFa34UWp_HFI785v_-7knzYZpHWQ_Nu-o0d1Ngk-v7Rj9jj1erh4ld2fffz98X5dWbzheozKlxdOqdtoSt0DsiVhUO31CQQEEQBwtVSVdIqW2ntqlzLHBbolLK6XJb5ETudfMeXngdKvWl92iXDjsbMRmolSr3QUIxSOUltDClFqs02-hbjqxFgdrDNxuxgmx1sM8Eej04-_IeqJffv5JPuKDibBDR--eIpmmQ9dZacj2R744L_n_8bABSR0Q</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Zhang, Deming</creator><creator>Pan, Gaofeng</creator><creator>Cheng, Nitao</creator><creator>Sun, Linao</creator><creator>Zhou, Xuefeng</creator><creator>Li, Changsheng</creator><creator>Zhao, Jinping</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202304</creationdate><title>JUND facilitates proliferation and angiogenesis of esophageal squamous cell carcinoma cell via MAPRE2 up-regulation</title><author>Zhang, Deming ; Pan, Gaofeng ; Cheng, Nitao ; Sun, Linao ; Zhou, Xuefeng ; Li, Changsheng ; Zhao, Jinping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-e4df9dd7c47badd0ed94dad87e1a0a01401df26b2c6cb77db372305ad66c79893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Angiogenesis</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement</topic><topic>Cell Proliferation - genetics</topic><topic>Endothelial Cells - metabolism</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Neoplasms - metabolism</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal squamous cell carcinoma</topic><topic>Esophageal Squamous Cell Carcinoma - genetics</topic><topic>Esophageal Squamous Cell Carcinoma - metabolism</topic><topic>Esophageal Squamous Cell Carcinoma - pathology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>JUND</topic><topic>MAPRE2</topic><topic>Matrix Metalloproteinase 9 - genetics</topic><topic>MicroRNAs - genetics</topic><topic>Microtubule-Associated Proteins - genetics</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>Neovascularization, Pathologic - genetics</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Proliferation</topic><topic>Proto-Oncogene Proteins c-jun - genetics</topic><topic>Proto-Oncogene Proteins c-jun - metabolism</topic><topic>RNA, Small Interfering</topic><topic>Transcription factor</topic><topic>Up-Regulation - genetics</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Deming</creatorcontrib><creatorcontrib>Pan, Gaofeng</creatorcontrib><creatorcontrib>Cheng, Nitao</creatorcontrib><creatorcontrib>Sun, Linao</creatorcontrib><creatorcontrib>Zhou, Xuefeng</creatorcontrib><creatorcontrib>Li, Changsheng</creatorcontrib><creatorcontrib>Zhao, Jinping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Tissue & cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Deming</au><au>Pan, Gaofeng</au><au>Cheng, Nitao</au><au>Sun, Linao</au><au>Zhou, Xuefeng</au><au>Li, Changsheng</au><au>Zhao, Jinping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>JUND facilitates proliferation and angiogenesis of esophageal squamous cell carcinoma cell via MAPRE2 up-regulation</atitle><jtitle>Tissue & cell</jtitle><addtitle>Tissue Cell</addtitle><date>2023-04</date><risdate>2023</risdate><volume>81</volume><spage>102010</spage><epage>102010</epage><pages>102010-102010</pages><artnum>102010</artnum><issn>0040-8166</issn><eissn>1532-3072</eissn><abstract>Esophageal squamous cell carcinoma (ESCC) is a globally aggressive malignant tumor. This study aimed to investigate the mechanism of JUND in ESCC development via MAPRE2.
ESCC cells (KYSE-450 and ECA109) were transfected with small interfering RNA (si)-JUND, si-MAPRE2, si-JUND, or pcDNA3.1-MAPRE2. JUND and MAPRE2 expression in ESCC cells was detected with quantitative real-time polymerase chain reaction and western blot. Cell counting kit-8 and 5-ethynyl-2′-deoxyuridine assays were used to determine ESCC cell proliferation. Dual-luciferase reporter gene and chromatin immunoprecipitation assays were performed to assess binding between JUND and MAPRE2. Human umbilical vein endothelial cells (HUVECs) were co-cultured with ESCC cell supernatants. Angiogenesis was assessed with an in vitro angiogenesis assay. Western blot was conducted to evaluate the expression of angiogenic proteins [vascular endothelial growth factor A (VEGFA), matrix metallopeptidase 9 (MMP-9), and angiopoietin-2 (ang2)].
The levels of expression of JUND and MAPRE2 were high in ESCC cells. Mechanistically, JUND bound to MAPRE2 promoter and increased MAPRE2 transcription. Downregulation of JUND or MAPRE2 inhibited KYSE-450 and ECA109 cell proliferation and reduced the levels of expression of VEGFA, MMP-9, and ang2 and tube formation in HUVECs co-cultured with ESCC cell supernatants. MAPRE2 upregulation counteracted the inhibitory effects of JUND silencing on cell proliferative and angiogenic capabilities in ESCC.
JUND promoted MAPRE2 transcription, thereby facilitating cell proliferative and angiogenic abilities in ESCC.
•MAPRE2 and JUND are highly expressed in ESCC cell lines.•MAPRE2 down-regulation suppresses cell proliferation and angiogenesis in ESCC.•JUND facilitates the transcription of MAPRE2.•JUND down-regulation curbs cell proliferation and angiogenesis in ESCC.•JUND promoted cell proliferation and angiogenesis in ESCC via MAPRE2.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>36608637</pmid><doi>10.1016/j.tice.2022.102010</doi><tpages>1</tpages></addata></record> |
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| subjects | Angiogenesis Cell Line, Tumor Cell Movement Cell Proliferation - genetics Endothelial Cells - metabolism Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal squamous cell carcinoma Esophageal Squamous Cell Carcinoma - genetics Esophageal Squamous Cell Carcinoma - metabolism Esophageal Squamous Cell Carcinoma - pathology Gene Expression Regulation, Neoplastic Humans JUND MAPRE2 Matrix Metalloproteinase 9 - genetics MicroRNAs - genetics Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Proliferation Proto-Oncogene Proteins c-jun - genetics Proto-Oncogene Proteins c-jun - metabolism RNA, Small Interfering Transcription factor Up-Regulation - genetics Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism |
| title | JUND facilitates proliferation and angiogenesis of esophageal squamous cell carcinoma cell via MAPRE2 up-regulation |
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