Yes-Associated Protein 1 Inhibition Induces Immunogenic Cell Death and Synergizes With Radiation and PD-1 Blockade

Danger signals released by ionizing radiation (IR) can theoretically stimulate immune activation in the tumor environment (TME), but IR alone is not sufficient to induce an effective immune response in clinical practice. In this study, we investigated whether inhibition of yes-associated protein 1 (...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2023-07, Vol.116 (4), p.894-905
Hauptverfasser:	Zhuang, Yuan, Wang, Yuzi, Liu, Chang, Li, Sihan, Du, Shuyan, Li, Guang
Format:	Artikel
Sprache:	eng
Schlagworte:	CD8-Positive T-Lymphocytes Humans Immunogenic Cell Death Immunotherapy - methods Lymphocyte Activation Pancreatic Neoplasms Programmed Cell Death 1 Receptor Tumor Microenvironment YAP-Signaling Proteins
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