Effect of microsampling (50 μL) on toxicological evaluation of methapyrilene, a hepatotoxic substance, in a collaborative 28-day study in female rats

Although microsampling of blood is recommended to promote the 3Rs in toxicokinetic (TK) evaluation, there are few reports applying microsampling in actual toxicity evaluation. Here, we assessed the effects of microsampling on toxicological evaluation of methapyrilene hydrochloride, a hepatotoxic sub...

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Veröffentlicht in:	Journal of toxicological sciences 2023, Vol.48(1), pp.1-14
Hauptverfasser:	Hattori, Norimichi, Yokoyama, Hideaki, Takumi, Asuka, Kawaguchi, Sayaka, Yamaguchi, Koki, Shimazaki, Taishi, Shibui, Yusuke, Saito, Kosuke, Saito, Yoshiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Blood Specimen Collection - methods Drug-Related Side Effects and Adverse Reactions Evaluation Female Females Hematology Hepatotoxicity Liver Methapyrilene - pharmacology Microsampling Necropsy Organizations Rats Rats, Sprague-Dawley Reproducibility of Results Sampling Toxicity Toxicokinetic Toxicological evaluation
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