Treatment of Gestational Diabetes Mellitus and Maternal Risk of Diabetes After Pregnancy
To compare postpartum glucose tolerance between women treated for gestational diabetes mellitus (GDM) and those not treated. Metabolic testing was performed at 3 and 12 months postpartum in 599 women comprising the following gestational glucose tolerance groups: 1) normal glucose challenge test (GCT...
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| Veröffentlicht in: | Diabetes care 2023-03, Vol.46 (3), p.587-592 |
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| creator | Retnakaran, Ravi Ye, Chang Hanley, Anthony J Connelly, Philip W Sermer, Mathew Zinman, Bernard |
| description | To compare postpartum glucose tolerance between women treated for gestational diabetes mellitus (GDM) and those not treated.
Metabolic testing was performed at 3 and 12 months postpartum in 599 women comprising the following gestational glucose tolerance groups: 1) normal glucose challenge test (GCT) and oral glucose tolerance test (OGTT) during pregnancy, 2) abnormal GCT with normal OGTT, 3) gestational impaired glucose tolerance, 4) mild untreated GDM, and 5) severe treated GDM.
Birth weight progressively increased across groups 1-4 before falling steeply in treated GDM (P < 0.0001). In contrast, at 3 and 12 months, insulin sensitivity and β-cell function progressively decreased across the five groups, mirrored by rising fasting and 2-h glucose (all P < 0.0001). Accordingly, prevalence of prediabetes/diabetes at 12 months increased in a stepwise manner across groups 1-5 (2.8%, 9.6%, 13.5%, 21.5%, and 32.6%, respectively; P < 0.0001).
Treating GDM lowers birth weight but does not disrupt the association between gestational glycemia and maternal prediabetes/diabetes after pregnancy. |
| doi_str_mv | 10.2337/dc22-1786 |
| format | Article |
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Metabolic testing was performed at 3 and 12 months postpartum in 599 women comprising the following gestational glucose tolerance groups: 1) normal glucose challenge test (GCT) and oral glucose tolerance test (OGTT) during pregnancy, 2) abnormal GCT with normal OGTT, 3) gestational impaired glucose tolerance, 4) mild untreated GDM, and 5) severe treated GDM.
Birth weight progressively increased across groups 1-4 before falling steeply in treated GDM (P < 0.0001). In contrast, at 3 and 12 months, insulin sensitivity and β-cell function progressively decreased across the five groups, mirrored by rising fasting and 2-h glucose (all P < 0.0001). Accordingly, prevalence of prediabetes/diabetes at 12 months increased in a stepwise manner across groups 1-5 (2.8%, 9.6%, 13.5%, 21.5%, and 32.6%, respectively; P < 0.0001).
Treating GDM lowers birth weight but does not disrupt the association between gestational glycemia and maternal prediabetes/diabetes after pregnancy.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc22-1786</identifier><identifier>PMID: 36602334</identifier><language>eng</language><publisher>United States: American Diabetes Association</publisher><subject>Beta cells ; Birth Weight ; Blood glucose ; Blood Glucose - metabolism ; Chromium ; Diabetes ; Diabetes mellitus ; Diabetes, Gestational - epidemiology ; Female ; Gestational diabetes ; Glucose ; Glucose tolerance ; Glucose Tolerance Test ; Health risks ; Humans ; Insulin ; Postpartum ; Prediabetic State ; Pregnancy ; Pregnancy complications ; Research design ; Womens health</subject><ispartof>Diabetes care, 2023-03, Vol.46 (3), p.587-592</ispartof><rights>2023 by the American Diabetes Association.</rights><rights>Copyright American Diabetes Association Mar 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-c0b185d381f73948d7930274e17adc05c7f414fa74b55248a272f373e6f0c6013</citedby><cites>FETCH-LOGICAL-c348t-c0b185d381f73948d7930274e17adc05c7f414fa74b55248a272f373e6f0c6013</cites><orcidid>0000-0003-1989-027X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36602334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Retnakaran, Ravi</creatorcontrib><creatorcontrib>Ye, Chang</creatorcontrib><creatorcontrib>Hanley, Anthony J</creatorcontrib><creatorcontrib>Connelly, Philip W</creatorcontrib><creatorcontrib>Sermer, Mathew</creatorcontrib><creatorcontrib>Zinman, Bernard</creatorcontrib><title>Treatment of Gestational Diabetes Mellitus and Maternal Risk of Diabetes After Pregnancy</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>To compare postpartum glucose tolerance between women treated for gestational diabetes mellitus (GDM) and those not treated.
Metabolic testing was performed at 3 and 12 months postpartum in 599 women comprising the following gestational glucose tolerance groups: 1) normal glucose challenge test (GCT) and oral glucose tolerance test (OGTT) during pregnancy, 2) abnormal GCT with normal OGTT, 3) gestational impaired glucose tolerance, 4) mild untreated GDM, and 5) severe treated GDM.
Birth weight progressively increased across groups 1-4 before falling steeply in treated GDM (P < 0.0001). In contrast, at 3 and 12 months, insulin sensitivity and β-cell function progressively decreased across the five groups, mirrored by rising fasting and 2-h glucose (all P < 0.0001). Accordingly, prevalence of prediabetes/diabetes at 12 months increased in a stepwise manner across groups 1-5 (2.8%, 9.6%, 13.5%, 21.5%, and 32.6%, respectively; P < 0.0001).
Treating GDM lowers birth weight but does not disrupt the association between gestational glycemia and maternal prediabetes/diabetes after pregnancy.</description><subject>Beta cells</subject><subject>Birth Weight</subject><subject>Blood glucose</subject><subject>Blood Glucose - metabolism</subject><subject>Chromium</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes, Gestational - epidemiology</subject><subject>Female</subject><subject>Gestational diabetes</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Glucose Tolerance Test</subject><subject>Health risks</subject><subject>Humans</subject><subject>Insulin</subject><subject>Postpartum</subject><subject>Prediabetic State</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Research design</subject><subject>Womens health</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkD1PwzAYhC0EoqUw8AdQJBYYAv6M7bEqUJBagVCR2CLHsVFKPortDP33xGrpwPQO99zp3gPgEsE7TAi_LzXGKeIiOwJjJAlLGaPiGIwhojJlUuIROPN-DSGkVIhTMCJZBgcnHYPPlTMqNKYNSWeTufFBhaprVZ08VKowwfhkaeq6Cr1PVFsmSxWMi_J75b-j5YBN7aAkb858tarV23NwYlXtzcX-TsDH0-Nq9pwuXucvs-ki1YSKkGpYIMFKIpDlRFJRckkg5tQgrkoNmeaWImoVpwVjmAqFObaEE5NZqDOIyATc7HI3rvvph_55U3k9VFat6XqfY54hJBDlEb3-h667Pj4TKQFRRqXkA3W7o7TrvHfG5htXNcptcwTzOHce587j3AN7tU_si8aUB_JvX_IL0lB4Pw</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Retnakaran, Ravi</creator><creator>Ye, Chang</creator><creator>Hanley, Anthony J</creator><creator>Connelly, Philip W</creator><creator>Sermer, Mathew</creator><creator>Zinman, Bernard</creator><general>American Diabetes Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1989-027X</orcidid></search><sort><creationdate>20230301</creationdate><title>Treatment of Gestational Diabetes Mellitus and Maternal Risk of Diabetes After Pregnancy</title><author>Retnakaran, Ravi ; Ye, Chang ; Hanley, Anthony J ; Connelly, Philip W ; Sermer, Mathew ; Zinman, Bernard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-c0b185d381f73948d7930274e17adc05c7f414fa74b55248a272f373e6f0c6013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Beta cells</topic><topic>Birth Weight</topic><topic>Blood glucose</topic><topic>Blood Glucose - metabolism</topic><topic>Chromium</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes, Gestational - epidemiology</topic><topic>Female</topic><topic>Gestational diabetes</topic><topic>Glucose</topic><topic>Glucose tolerance</topic><topic>Glucose Tolerance Test</topic><topic>Health risks</topic><topic>Humans</topic><topic>Insulin</topic><topic>Postpartum</topic><topic>Prediabetic State</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Research design</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Retnakaran, Ravi</creatorcontrib><creatorcontrib>Ye, Chang</creatorcontrib><creatorcontrib>Hanley, Anthony J</creatorcontrib><creatorcontrib>Connelly, Philip W</creatorcontrib><creatorcontrib>Sermer, Mathew</creatorcontrib><creatorcontrib>Zinman, Bernard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Retnakaran, Ravi</au><au>Ye, Chang</au><au>Hanley, Anthony J</au><au>Connelly, Philip W</au><au>Sermer, Mathew</au><au>Zinman, Bernard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of Gestational Diabetes Mellitus and Maternal Risk of Diabetes After Pregnancy</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>46</volume><issue>3</issue><spage>587</spage><epage>592</epage><pages>587-592</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><abstract>To compare postpartum glucose tolerance between women treated for gestational diabetes mellitus (GDM) and those not treated.
Metabolic testing was performed at 3 and 12 months postpartum in 599 women comprising the following gestational glucose tolerance groups: 1) normal glucose challenge test (GCT) and oral glucose tolerance test (OGTT) during pregnancy, 2) abnormal GCT with normal OGTT, 3) gestational impaired glucose tolerance, 4) mild untreated GDM, and 5) severe treated GDM.
Birth weight progressively increased across groups 1-4 before falling steeply in treated GDM (P < 0.0001). In contrast, at 3 and 12 months, insulin sensitivity and β-cell function progressively decreased across the five groups, mirrored by rising fasting and 2-h glucose (all P < 0.0001). Accordingly, prevalence of prediabetes/diabetes at 12 months increased in a stepwise manner across groups 1-5 (2.8%, 9.6%, 13.5%, 21.5%, and 32.6%, respectively; P < 0.0001).
Treating GDM lowers birth weight but does not disrupt the association between gestational glycemia and maternal prediabetes/diabetes after pregnancy.</abstract><cop>United States</cop><pub>American Diabetes Association</pub><pmid>36602334</pmid><doi>10.2337/dc22-1786</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1989-027X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes care, 2023-03, Vol.46 (3), p.587-592 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Beta cells Birth Weight Blood glucose Blood Glucose - metabolism Chromium Diabetes Diabetes mellitus Diabetes, Gestational - epidemiology Female Gestational diabetes Glucose Glucose tolerance Glucose Tolerance Test Health risks Humans Insulin Postpartum Prediabetic State Pregnancy Pregnancy complications Research design Womens health |
| title | Treatment of Gestational Diabetes Mellitus and Maternal Risk of Diabetes After Pregnancy |
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