The Effect of α2-Adrenoreceptors Blockade on the Isolated Rat Heart during the Formation of Sympathetic Innervation
We studied the effects of the α 2 -adrenergic receptor antagonist yohimbine (10 –9 -10 –6 M) on inotropy, chronotropy, and coronary flow in the Langendorff-isolated heart from 3- and 6-week-old rats. Yohimbine affected all the studied functional parameters of the isolated heart. The force of contrac...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2022-12, Vol.174 (2), p.226-229 |
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| creator | Zefirov, T. L. Khisamieva, L. I. Kuptsova, A. M. Ziyatdinova, N. I. Zefirov, A. L. |
| description | We studied the effects of the α
2
-adrenergic receptor antagonist yohimbine (10
–9
-10
–6
M) on inotropy, chronotropy, and coronary flow in the Langendorff-isolated heart from 3- and 6-week-old rats. Yohimbine affected all the studied functional parameters of the isolated heart. The force of contraction of the left ventricular myocardium, HR, and coronary flow decreased at all studied concentrations of the antagonist. The maximum chronotropic effect was observed in the heart from 6-week-old rats in the presence of 10
–6
M yohimbine in the perfused solution and in the heart from 3-week-old rats in the presence of 10
–9
M yohimbine. The minimum chronotropic and inotropic effect was recorded in the hearts from 6-week-old animals after application of 10
–9
M α
2
-adrenergic receptor blocker and in the hearts from 3-week-old animals at yohimbine concentration of 10
–7
M. The least pronounced decrease in coronary flow in 3- and 6-week-old rats was observed at the minimum concentration of yohimbine. |
| doi_str_mv | 10.1007/s10517-023-05678-5 |
| format | Article |
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2
-adrenergic receptor antagonist yohimbine (10
–9
-10
–6
M) on inotropy, chronotropy, and coronary flow in the Langendorff-isolated heart from 3- and 6-week-old rats. Yohimbine affected all the studied functional parameters of the isolated heart. The force of contraction of the left ventricular myocardium, HR, and coronary flow decreased at all studied concentrations of the antagonist. The maximum chronotropic effect was observed in the heart from 6-week-old rats in the presence of 10
–6
M yohimbine in the perfused solution and in the heart from 3-week-old rats in the presence of 10
–9
M yohimbine. The minimum chronotropic and inotropic effect was recorded in the hearts from 6-week-old animals after application of 10
–9
M α
2
-adrenergic receptor blocker and in the hearts from 3-week-old animals at yohimbine concentration of 10
–7
M. The least pronounced decrease in coronary flow in 3- and 6-week-old rats was observed at the minimum concentration of yohimbine.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-023-05678-5</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adrenergic receptors ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Heart ; Innervation ; Internal Medicine ; Laboratory Medicine ; Myocardium ; Pathology ; Ventricle ; Yohimbine</subject><ispartof>Bulletin of experimental biology and medicine, 2022-12, Vol.174 (2), p.226-229</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1485-20ff2f4fed703304e31183067ad5f7ece5b7fc55e6a2886629f2d3f7acfa300f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-023-05678-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-023-05678-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Zefirov, T. L.</creatorcontrib><creatorcontrib>Khisamieva, L. I.</creatorcontrib><creatorcontrib>Kuptsova, A. M.</creatorcontrib><creatorcontrib>Ziyatdinova, N. I.</creatorcontrib><creatorcontrib>Zefirov, A. L.</creatorcontrib><title>The Effect of α2-Adrenoreceptors Blockade on the Isolated Rat Heart during the Formation of Sympathetic Innervation</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><description>We studied the effects of the α
2
-adrenergic receptor antagonist yohimbine (10
–9
-10
–6
M) on inotropy, chronotropy, and coronary flow in the Langendorff-isolated heart from 3- and 6-week-old rats. Yohimbine affected all the studied functional parameters of the isolated heart. The force of contraction of the left ventricular myocardium, HR, and coronary flow decreased at all studied concentrations of the antagonist. The maximum chronotropic effect was observed in the heart from 6-week-old rats in the presence of 10
–6
M yohimbine in the perfused solution and in the heart from 3-week-old rats in the presence of 10
–9
M yohimbine. The minimum chronotropic and inotropic effect was recorded in the hearts from 6-week-old animals after application of 10
–9
M α
2
-adrenergic receptor blocker and in the hearts from 3-week-old animals at yohimbine concentration of 10
–7
M. The least pronounced decrease in coronary flow in 3- and 6-week-old rats was observed at the minimum concentration of yohimbine.</description><subject>Adrenergic receptors</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Heart</subject><subject>Innervation</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Myocardium</subject><subject>Pathology</subject><subject>Ventricle</subject><subject>Yohimbine</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kctKQzEQhoMoWC8v4Crgxk00l-bSpYrVgiB4WYeYM9GjpyfHJBV8LF_EZzJtBcGFq2Fmvv9nmB-hA0aPGaX6JDMqmSaUC0Kl0obIDTRiUgtiOGebaEQrRcbGmG20k_PLsqWKjVC5fwZ8EQL4gmPAX5-cnDYJ-pjAw1Biyvisi_7VNYBjj0ulZzl2rkCDb13BV-BSwc0itf3TajuNae5KW9lqd_cxH1ydltbjWd9Del-t9tBWcF2G_Z-6ix6mF_fnV-T65nJ2fnpNPBsbSTgNgYdxgEZTIegYBGNGUKVdI4Ou98lHHbyUoBw3Rik-CbwRQTsfnKA0iF10tPYdUnxbQC523mYPXed6iItsuVaM6Qk1k4oe_kFf4iL19bolJZhiXIlK8TXlU8w5QbBDaucufVhG7TIIuw7C1iDsKggrq0isRXlYfgnSr_U_qm_Fy4wZ</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Zefirov, T. 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M. ; Ziyatdinova, N. I. ; Zefirov, A. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1485-20ff2f4fed703304e31183067ad5f7ece5b7fc55e6a2886629f2d3f7acfa300f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adrenergic receptors</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Heart</topic><topic>Innervation</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Myocardium</topic><topic>Pathology</topic><topic>Ventricle</topic><topic>Yohimbine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zefirov, T. L.</creatorcontrib><creatorcontrib>Khisamieva, L. I.</creatorcontrib><creatorcontrib>Kuptsova, A. M.</creatorcontrib><creatorcontrib>Ziyatdinova, N. I.</creatorcontrib><creatorcontrib>Zefirov, A. 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L.</au><au>Khisamieva, L. I.</au><au>Kuptsova, A. M.</au><au>Ziyatdinova, N. I.</au><au>Zefirov, A. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of α2-Adrenoreceptors Blockade on the Isolated Rat Heart during the Formation of Sympathetic Innervation</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>174</volume><issue>2</issue><spage>226</spage><epage>229</epage><pages>226-229</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>We studied the effects of the α
2
-adrenergic receptor antagonist yohimbine (10
–9
-10
–6
M) on inotropy, chronotropy, and coronary flow in the Langendorff-isolated heart from 3- and 6-week-old rats. Yohimbine affected all the studied functional parameters of the isolated heart. The force of contraction of the left ventricular myocardium, HR, and coronary flow decreased at all studied concentrations of the antagonist. The maximum chronotropic effect was observed in the heart from 6-week-old rats in the presence of 10
–6
M yohimbine in the perfused solution and in the heart from 3-week-old rats in the presence of 10
–9
M yohimbine. The minimum chronotropic and inotropic effect was recorded in the hearts from 6-week-old animals after application of 10
–9
M α
2
-adrenergic receptor blocker and in the hearts from 3-week-old animals at yohimbine concentration of 10
–7
M. The least pronounced decrease in coronary flow in 3- and 6-week-old rats was observed at the minimum concentration of yohimbine.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10517-023-05678-5</doi><tpages>4</tpages></addata></record> |
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| subjects | Adrenergic receptors Biomedical and Life Sciences Biomedicine Cell Biology Heart Innervation Internal Medicine Laboratory Medicine Myocardium Pathology Ventricle Yohimbine |
| title | The Effect of α2-Adrenoreceptors Blockade on the Isolated Rat Heart during the Formation of Sympathetic Innervation |
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