Stereodivergent Construction of 1,3‐Chiral Centers via Tandem Asymmetric Conjugate Addition and Allylic Substitution Reaction

Herein, we report a synthesis of cyclohexanones bearing multi‐continuous stereocenters by combining copper‐catalyzed asymmetric conjugate addition of dialkylzinc reagents to cyclic enones with iridium‐catalyzed asymmetric allylic substitution reaction. Good to excellent yields, diastereoselectivity...

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Veröffentlicht in:	Angewandte Chemie International Edition 2023-03, Vol.62 (10), p.e202216396-n/a
Hauptverfasser:	Xie, Jia‐Hao, Hou, Yi‐Ming, Feng, Zuolijun, You, Shu‐Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Allylic Substitution Asymmetric Catalysis Asymmetry Catalysts Conjugate Addition Conjugates Cyclohexanone Enantiomers Iridium Reagents Stereodivergent Stereoselectivity Substitution reactions Transition Metal Catalyzed
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