Antinociceptive Effect of Ethowurtzine, a New Compound from the Class of Hexaazaizowurzitane
Analysis of specific pharmacological activity evaluated high antinociceptive efficacy of the first synthesized compound 10-di(ethoxyacetyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,0 3,11 ,0 5,9 ]dodecane (ethowurtzine) in models of somatogenic pain of different genesis (thermal, v...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2022-12, Vol.174 (2), p.230-235 |
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| creator | Krylova, S. G. Kiseleva, E. A. Povet’eva, T. N. Nesterova, Yu. V. Rybalkina, O. Yu Kul’pin, P. V. Afanas’eva, O. G. Kulagina, D. A. Eremina, V. V. Baibakova, O. V. Zueva, E. P. Suslov, N. I. Sysolyatin, S. V. Zhdanov, V. V. |
| description | Analysis of specific pharmacological activity evaluated high antinociceptive efficacy of the first synthesized compound 10-di(ethoxyacetyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,0
3,11
,0
5,9
]dodecane (ethowurtzine) in models of somatogenic pain of different genesis (thermal, visceral pain, mechanical compression of paw).The new molecule from the class of hexaazaisowurtzitane effectively blocks nociceptive reactions at the supraspinal and peripheral levels of pain sensitivity organization. The effect of ethowurtzine was comparable or exceeded the effect of tramadol. The obtained results prove the possibility of creating new pharmacologically active molecules based on the high-energy substance hexaazaisowurtzitane. |
| doi_str_mv | 10.1007/s10517-023-05679-4 |
| format | Article |
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3,11
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3,11
,0
5,9
]dodecane (ethowurtzine) in models of somatogenic pain of different genesis (thermal, visceral pain, mechanical compression of paw).The new molecule from the class of hexaazaisowurtzitane effectively blocks nociceptive reactions at the supraspinal and peripheral levels of pain sensitivity organization. The effect of ethowurtzine was comparable or exceeded the effect of tramadol. The obtained results prove the possibility of creating new pharmacologically active molecules based on the high-energy substance hexaazaisowurtzitane.</description><subject>Analgesics</subject><subject>Analgesics - pharmacology</subject><subject>Analgesics - therapeutic use</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Chemical synthesis</subject><subject>Compression</subject><subject>Dodecane</subject><subject>Drug dosages</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Medical research</subject><subject>Opioids</subject><subject>Pain</subject><subject>Pain - drug therapy</subject><subject>Pain Measurement - methods</subject><subject>Pain perception</subject><subject>Pain Threshold</subject><subject>Pathology</subject><subject>Pharmacology</subject><subject>Regenerative medicine</subject><subject>Research centers</subject><subject>Tramadol</subject><subject>Tramadol - pharmacology</subject><subject>Tramadol - therapeutic use</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kV1rFDEYhYModl39A17IgCBeODWZfM7lsmytUPRG74SQnXnTTZlJ1iRjdX99M261VkRyEZI853DeHISeE3xKMJZvE8GcyBo3tMZcyLZmD9CCcElr1TTkIVrgQtVMKXWCnqR0NR-xII_RCRW8VUKwBfqy8tn50LkO9tl9g2pjLXS5Crba5F24nmI-OA9vKlN9gOtqHcZ9mHxf2RjGKu-gWg8mpRk_h-_GHIw7zKKDy8bDU_TImiHBs9t9iT6fbT6tz-uLj-_er1cXdcckzTW1inetwpY2TBjBGszKPIrbXloiG8m3SlEqWmUxYRQzzqwRtCfcgCKwVXSJXh999zF8nSBlPbrUwTCUDGFKupECK9IWy4K-_Au9ClP0Jd1MUSIIZeyOujQDaOdtyNF0s6leSSYaKmX59SU6_QdVVg-j64IH68r9PcGrPwQ7MEPepTBM2QWf7oPNEexiSCmC1fvoRhN_aIL13L0-dq8Lq392r-fQL25Hm7Yj9L8lv8ouAD0CqTz5S4h3s__H9gaYa7V4</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Krylova, S. 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G. ; Kiseleva, E. A. ; Povet’eva, T. N. ; Nesterova, Yu. V. ; Rybalkina, O. Yu ; Kul’pin, P. V. ; Afanas’eva, O. G. ; Kulagina, D. A. ; Eremina, V. V. ; Baibakova, O. V. ; Zueva, E. P. ; Suslov, N. I. ; Sysolyatin, S. V. ; Zhdanov, V. 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| ispartof | Bulletin of experimental biology and medicine, 2022-12, Vol.174 (2), p.230-235 |
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| subjects | Analgesics Analgesics - pharmacology Analgesics - therapeutic use Analgesics, Opioid - pharmacology Animals Biomedical and Life Sciences Biomedicine Cell Biology Chemical synthesis Compression Dodecane Drug dosages Humans Internal Medicine Laboratory Medicine Medical research Opioids Pain Pain - drug therapy Pain Measurement - methods Pain perception Pain Threshold Pathology Pharmacology Regenerative medicine Research centers Tramadol Tramadol - pharmacology Tramadol - therapeutic use |
| title | Antinociceptive Effect of Ethowurtzine, a New Compound from the Class of Hexaazaizowurzitane |
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