Decursin inhibits EGFR‐ERK1/2 signaling axis in advanced human prostate carcinoma cells

We have shown that decursin, a coumarin compound, induces cell cycle arrest and apoptosis in human prostate cancer cells (PCa); however, its molecular mechanisms are largely unexplored. We studied the mechanisms associated with its anticancer activity in advanced human prostate carcinoma cells. We f...

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Veröffentlicht in:	The Prostate 2023-05, Vol.83 (6), p.534-546
Hauptverfasser:	Bhat, Tariq A., Dheeraj, Arpit, Nambiar, Dhanya K., Singh, Surya Pratap, Yim, Dong Sool, Singh, Rana P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor activity Apoptosis Cancer Carcinoma - metabolism Cell cycle Cell death Cell growth Cell proliferation Cyclin-dependent kinase 4 Cyclin-dependent kinase inhibitor p27 Cytotoxicity decursin E2F protein EGFR Epidermal Growth Factor Epidermal growth factor receptors ErbB Receptors - metabolism ERK1/2 Erlotinib Hydrochloride - metabolism Erlotinib Hydrochloride - pharmacology Extracellular signal-regulated kinase G1 phase Humans Kinases Ligands Male Malignancy MAP Kinase Signaling System Molecular modelling Phosphorylation Prostate Prostate - pathology Prostate cancer Prostate carcinoma Prostatic Neoplasms - pathology Transcription factors Tyrosine
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